Imines

Publication Title: 
Journal of Neurochemistry

The search for effective treatments that prevent oxidative stress associated with premature ageing and neurodegenerative diseases is an important area of neurochemical research. As age- and disease-related oxidative stress is frequently associated with mitochondrial dysfunction, amphiphilic antioxidant agents of high stability and selectivity that target these organelles can provide on-site protection.

Author(s): 
Poeggeler, Burkhard
Durand, GrÈgory
Polidori, Ange
Pappolla, Miguel A.
Vega-Naredo, Ignacio
Coto-Montes, Ana
Bˆker, Jutta
Hardeland, R¸diger
Pucci, Bernard
Publication Title: 
Carbohydrate Research

Natural products with interesting biological properties and structural diversity have often served as valuable lead drug candidates for the treatment of human diseases. Salacinol, a naturally occurring alpha-glucosidase inhibitor, was shown to be one of the active principles of the aqueous extract of a medicinal plant that has been prescribed traditionally as an Ayurvedic treatment for type II diabetes. Salacinol contains an intriguing zwitterionic sulfonium-sulfate structure that comprises a 1,4-anhydro-4-thio-D-arabinitol core and a polyhydroxylated acyclic chain.

Author(s): 
Mohan, Sankar
Pinto, B. Mario
Publication Title: 
Chemistry & Biology

BACKGROUND: Articular cartilage from patients with osteoarthritis is characterized by a decreased concentration and reduced size of glycosaminoglycans. Degeneration of the cartilage matrix is a multifactorial process, which is due in part to accelerated glycosaminoglycan catabolism. Recently, we have demonstrated that hexosaminidase represents the dominant glycosaminoglycan-degrading glycosidase released by chondrocytes into the extracellular compartment and is the dominant glycosidase in synovial fluid from patients with osteoarthritis.

Author(s): 
Liu, J.
Shikhman, A. R.
Lotz, M. K.
Wong, C. H.
Publication Title: 
Drug Metabolism and Disposition: The Biological Fate of Chemicals

CYP2E1 is widely accepted as the sole form of cytochrome P450 responsible for alcohol-mediated increases in acetaminophen (APAP) hepatotoxicity. However, we previously found that alcohol [ethanol and isopentanol (EIP)] causes increases in APAP hepatotoxicity in Cyp2e1(-/-) mice, indicating that CYP2E1 is not essential. Here, using wild-type and Cyp2e1(-/-) mice, we investigated the relative roles of CYP2E1 and CYP3A in EIP-mediated increases in APAP hepatotoxicity.

Author(s): 
Wolf, Kristina K.
Wood, Sheryl G.
Allard, Jenna L.
Hunt, Jane A.
Gorman, Nadia
Walton-Strong, Brooke W.
Szakacs, Juliana G.
Duan, Su X.
Hao, Qin
Court, Michael H.
von Moltke, Lisa L.
Greenblatt, David J.
Kostrubsky, Vsevolod
Jeffery, Elizabeth H.
Wrighton, Steven A.
Gonzalez, Frank J.
Sinclair, Peter R.
Sinclair, Jacqueline F.
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