Immunomodulation

Publication Title: 
Journal of Dental Research

Discoveries of immunomodulatory functions in mesenchymal stem cells (MSCs) have suggested that they might have therapeutic utility in treating immune diseases. Recently, a novel MSC population was identified from dental pulp of human supernumerary teeth, and its multipotency characterized. Herein, we first examined the in vitro and in vivo immunomodulatory functions of human supernumerary tooth-derived stem cells (SNTSCs).

Author(s): 
Makino, Y.
Yamaza, H.
Akiyama, K.
Ma, L.
Hoshino, Y.
Nonaka, K.
Terada, Y.
Kukita, T.
Shi, S.
Yamaza, T.
Publication Title: 
European Child & Adolescent Psychiatry

Attention-deficit hyperactivity disorder (ADHD) etiology is not completely understood, but common comorbid dysfunction of the gastrointestinal and immune system suggests that these systems may be affected by a common genetic background and molecular mechanisms. For example, increased levels of specific cytokines were observed in ADHD. Moreover, ADHD has a high comorbidity with both Th1- and Th2-mediated disorders like ear infections, eczema and asthma.

Author(s): 
Verlaet, Annelies A. J.
Noriega, Daniela Briceno
Hermans, Nina
Savelkoul, Huub F. J.
Publication Title: 
PloS One

Earlier studies in this laboratory have shown the potential of artemisinin-curcumin combination therapy in experimental malaria. In a parasite recrudescence model in mice infected with Plasmodium berghei (ANKA), a single dose of alpha,beta-arteether (ART) with three oral doses of curcumin prevented recrudescence, providing almost 95% protection. The parasites were completely cleared in blood with ART-alone (AE) or ART+curcumin (AC) treatments in the short-term, although the clearance was faster in the latter case involving increased ROS generation.

Author(s): 
Vathsala, Palakkod G.
Dende, Chaitanya
Nagaraj, Viswanathan Arun
Bhattacharya, Debapriya
Das, Gobardhan
Rangarajan, Pundi N.
Padmanaban, Govindarajan
Publication Title: 
International Journal of Biological Macromolecules

Asparagus racemosus Linn. (Fam. Liliaceae) is an ethno-pharmacologically acclaimed Ayurvedic medicinal plant. In the present study, aqueous extract of A. racemosus (ARC) was fractionated and screened for the polysaccharide fraction (ARP). The characterization was done by enzymatic, Size Exclusion, gas chromatography with flame ionization detector (GC-FID), high pressure anion exchange chromatography (HPAEC) and thin layer chromatographic analyses. Phyto-chemical evaluation confirmed the presence of 26.7% of 2→1 linked fructo-oligosaccharides (FOS).

Author(s): 
Thakur, Mayank
Connellan, Paul
Deseo, Myrna A.
Morris, Carol
Praznik, Werner
Loeppert, Renate
Dixit, V. K.
Publication Title: 
International Immunopharmacology

Mesua ferrea L. (Nagkesar) is traditionally being used for antiseptic, anti-inflammatory, antiasthmatic and antiallergic activities. It is an ingredient of ayurvedic formulations like Brahma Rasayana and Chyavanprash which are being used to improve immunity. The present study was performed to evaluate immunomodulatory activity of mesuol isolated from M. ferrea seed oil in experimental animals.

Author(s): 
Chahar, Manoj Kumar
Sanjaya Kumar, D. S.
Lokesh, T.
Manohara, K. P.
Publication Title: 
Indian Journal of Experimental Biology

Guduchi has been widely used in the traditional medicine as an immunomodulator. Description of guduchi in Ayurvedic literature resemble with T. sinensis rather than with commonly available T. cordifolia and hence this may be used as substitutes for T. sinensis. T. cordifolia growing on Azadirachta indica commonly called Neem-guduchi has more immunomodulatory potential. Thus, immunomodulatory activity of three Tinospora spp.

Author(s): 
Narkhede, A. N.
Jagtap, S. D.
Kasote, D. M.
Kulkarni, O. P.
Harsulkar, A. M.
Publication Title: 
Annals of Allergy, Asthma & Immunology: Official Publication of the American College of Allergy, Asthma, & Immunology

BACKGROUND: Food allergy is a common and serious health problem. A new herbal product, called food allergy herbal formula 2 (FAHF-2), has been demonstrated to have a high safety profile and potent long-term efficacy in a murine model of peanut-induced anaphylaxis. OBJECTIVE: To evaluate the safety and tolerability of FAHF-2 in patients with food allergy. METHODS: In this randomized, double-blinded, placebo-controlled, dose escalation, phase 1 trial, patients received 1 of 3 doses of FAHF-2 or placebo: 2.2 g (4 tablets), 3.3 g (6 tablets), or 6.6 g (12 tablets) 3 times a day for 7 days.

Author(s): 
Wang, Julie
Patil, Sangita P.
Yang, Nan
Ko, Jimmy
Lee, Joohee
Noone, Sally
Sampson, Hugh A.
Li, Xiu-Min
Publication Title: 
Mucosal Immunology

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is widely expressed in macrophages and has been identified as a putative target for the development of novel therapies against inflammatory bowel disease (IBD). Computational simulations identified macrophages as key targets for therapeutic interventions against IBD. This study aimed to characterize the mechanisms underlying the beneficial effects of macrophage PPAR-γ in IBD.

Author(s): 
Hontecillas, R.
Horne, W. T.
Climent, M.
Guri, A. J.
Evans, C.
Zhang, Y.
Sobral, B. W.
Bassaganya-Riera, J.
Publication Title: 
Immunology and Allergy Clinics of North America

Allergy describes a constellation of clinical diseases that affect up to 30% of the world's population. It is characterized by production of allergen-specific IgE, which binds to mast cells and initiates a cascade of molecular and cellular events that affect the respiratory tract (rhinitis and asthma), skin (dermatitis, urticaria), and multiple systems (anaphylaxis) in response to a variety of allergens including pollens, mold spores, animal danders, insect stings, foods, and drugs.

Author(s): 
Dave, Ninabahen D.
Xiang, Lianbin
Rehm, Kristina E.
Marshall, Gailen D.
Publication Title: 
Clinical Immunology (Orlando, Fla.)

Galectin-1 (Gal-1) is one of 15 evolutionarily conserved ß-galactoside-binding proteins that display biologically-diverse activities in pathogenesis of inflammation and cancer. Gal-1 is variably expressed on immune cells and endothelial cells, though is commonly found and secreted at high levels in cancer cells. It induces apoptosis in effector T cells through homodimeric binding of N-acetyllactosamines on membrane glycoproteins (Gal-1 ligands).

Author(s): 
Cedeno-Laurent, Filiberto
Dimitroff, Charles J.

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