Immunotherapy

Publication Title: 
Journal of the Royal College of Physicians of London

Allergy is an exaggerated response of the immune system to external substances. It plays a role in a wide range of diseases. In some, such as summer hayfever, the symptoms are entirely due to allergy. In other conditions, particularly asthma, eczema and urticaria, allergy plays a part in some patients but not all. In these situations, allergy may either have a major role or provide just one of many triggers. In an individual patient's illness, the importance of allergy may change with time.

Publication Title: 
BMJ (Clinical research ed.)

OBJECTIVE: To test the hypothesis that homoeopathy is a placebo by examining its effect in patients with allergic rhinitis and so contest the evidence from three previous trials in this series. DESIGN: Randomised, double blind, placebo controlled, parallel group, multicentre study. SETTING: Four general practices and a hospital ear, nose, and throat outpatient department. PARTICIPANTS: 51 patients with perennial allergic rhinitis. INTERVENTION: Random assignment to an oral 30c homoeopathic preparation of principal inhalant allergen or to placebo.

Author(s): 
Taylor, M. A.
Reilly, D.
Llewellyn-Jones, R. H.
McSharry, C.
Aitchison, T. C.
Publication Title: 
Lancet (London, England)

We tested, under independent conditions, the reproducibility of evidence from two previous trials that homoeopathy differs from placebo. The test model was again homoeopathic immunotherapy. 28 patients with allergic asthma, most of them sensitive to house-dust mite, were randomly allocated to receive either oral homoeopathic immunotherapy to their principal allergen or identical placebo. The test treatments were given as a complement to their unaltered conventional care. A daily visual analogue scale of overall symptom intensity was the outcome measure.

Author(s): 
Reilly, D.
Taylor, M. A.
Beattie, N. G.
Campbell, J. H.
McSharry, C.
Aitchison, T. C.
Carter, R.
Stevenson, R. D.
Publication Title: 
Journal of the Royal College of Physicians of London

Allergy is an exaggerated response of the immune system to external substances. It plays a role in a wide range of diseases. In some, such as summer hayfever, the symptoms are entirely due to allergy. In other conditions, particularly asthma, eczema and urticaria, allergy plays a part in some patients but not all. In these situations, allergy may either have a major role or provide just one of many triggers. In an individual patient's illness, the importance of allergy may change with time.

Publication Title: 
Otolaryngology--Head and Neck Surgery: Official Journal of American Academy of Otolaryngology-Head and Neck Surgery

OBJECTIVE: Allergic rhinitis (AR) is one of the most common diseases affecting adults. It is the most common chronic disease in children in the United States today and the fifth most common chronic disease in the United States overall. AR is estimated to affect nearly 1 in every 6 Americans and generates $2 to $5 billion in direct health expenditures annually. It can impair quality of life and, through loss of work and school attendance, is responsible for as much as $2 to $4 billion in lost productivity annually.

Author(s): 
Seidman, Michael D.
Gurgel, Richard K.
Lin, Sandra Y.
Schwartz, Seth R.
Baroody, Fuad M.
Bonner, James R.
Dawson, Douglas E.
Dykewicz, Mark S.
Hackell, Jesse M.
Han, Joseph K.
Ishman, Stacey L.
Krouse, Helene J.
Malekzadeh, Sonya
Mims, James Whit W.
Omole, Folashade S.
Reddy, William D.
Wallace, Dana V.
Walsh, Sandra A.
Warren, Barbara E.
Wilson, Meghan N.
Nnacheta, Lorraine C.
Guideline Otolaryngology Development Group. AAO-HNSF
Publication Title: 
International Journal of Oncology

Granulocyte macrophage colony-stimulating factor (GM-CSF) is a key cytokine for the generation and stimulation of dendritic cells (DCs), and it may also play a pivotal role in promoting the survival of DCs. In this study, the feasibility of creating a cancer vaccine using DCs adenovirally transduced with the carcinoembryonic antigen (CEA) gene and the GM-CSF gene was examined. In addition, the effect of the co-transduction of GM-CSF gene on the lifespan of these genetically modified DCs was determined.

Author(s): 
Ojima, Toshiyasu
Iwahashi, Makoto
Nakamura, Masaki
Matsuda, Kenji
Nakamori, Mikihito
Ueda, Kentaro
Naka, Teiji
Katsuda, Masahiro
Miyazawa, Motoki
Yamaue, Hiroki
Publication Title: 
Journal of Dental Research

Discoveries of immunomodulatory functions in mesenchymal stem cells (MSCs) have suggested that they might have therapeutic utility in treating immune diseases. Recently, a novel MSC population was identified from dental pulp of human supernumerary teeth, and its multipotency characterized. Herein, we first examined the in vitro and in vivo immunomodulatory functions of human supernumerary tooth-derived stem cells (SNTSCs).

Author(s): 
Makino, Y.
Yamaza, H.
Akiyama, K.
Ma, L.
Hoshino, Y.
Nonaka, K.
Terada, Y.
Kukita, T.
Shi, S.
Yamaza, T.
Publication Title: 
Revue De Laryngologie - Otologie - Rhinologie

OBJECTIVE: Authors reported the results of a study on the application of immunonutrion in peri-operative (pre and postoperative) in head and neck cancer for all patients malnourished or not. In preoperative we used an oral treatmentand in postoperative an enteral one. MATERIALS AND METHODS: Prospective study concerning 78 patients (47 malnourished versus 31 not) having had heavy head and neck curative cancerology surgery. The mean follow up was of 10 months (from 7 to 16 month).

Author(s): 
Mayaleh, H. Abou
Vayer, C.
Amsellem, C.
Bouvet, A.
Duval, N.
Poiree, B.
Tran, M.
Lepeltier, V.
Hitier, M.
Rame, J. P.
Louis, Y.
De Raucourt, D.
Publication Title: 
Neuro-Oncology

BACKGROUND: Regulatory T cells (Tregs) are potentially prognostic indicators in patients with glioblastoma. If differences in frequency of Tregs in tumor or blood account for substantial variation in patient survival, then reliably measuring Tregs may enhance treatment selection and improve outcomes. METHODS: We measured Tregs and CD3+ T cells in tumors and blood from 25 patients with newly diagnosed glioblastoma.

Author(s): 
Thomas, Alissa A.
Fisher, Jan L.
Rahme, Gilbert J.
Hampton, Thomas H.
Baron, Udo
Olek, Sven
Schwachula, Tim
Rhodes, C. Harker
Gui, Jiang
Tafe, Laura J.
Tsongalis, Gregory J.
Lefferts, Joel A.
Wishart, Heather
Kleen, Jonathan
Miller, Michael
Whipple, Chery A.
de Abreu, Francine B.
Ernstoff, Marc S.
Fadul, Camilo E.
Publication Title: 
Journal of the Royal College of Physicians of London

Allergy is an exaggerated response of the immune system to external substances. It plays a role in a wide range of diseases. In some, such as summer hayfever, the symptoms are entirely due to allergy. In other conditions, particularly asthma, eczema and urticaria, allergy plays a part in some patients but not all. In these situations, allergy may either have a major role or provide just one of many triggers. In an individual patient's illness, the importance of allergy may change with time.

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