Individualized Medicine

Publication Title: 
The International Journal of Clinical and Experimental Hypnosis

Hypnosis has already been proven efficient in treatment of irritable bowel syndrome (IBS). The author was responsible for the hypnotherapy in a Swedish study and adds her clinical experience with IBS patients within and beyond that study. The hypnosis was labeled dynamic, and the treatment utilized the therapists' clinical competence and individually tailored techniques, including gut-oriented symptom relief and hypnoanalysis, separately or in combination. The author presents 2 cases, 1 with a focus on symptom relief and 1 on exploring traumatic causes.

Author(s): 
Carolusson, Susanna
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: This is a preliminary report on the development of a scale to measure the symptoms of unmāda (psychosis) attributable to tridosa (metabolic principles) by using the concepts of Ayurvedic medicine. DESIGN: The 67-item unmāda specific symptom scale was developed on the basis of translation of Sanskrit verses describing vātaja (V), pittaja (P), and kaphaja (K) unmāda (specific symptoms of psychosis due to the imbalances of metabolic components) and by taking the opinions of experts (15 Ayurveda experts, 5 psychiatrists, and 5 psychologists).

Author(s): 
Suchitra, Sureshrao P.
Devika, Honagalli S.
Gangadhar, Bangalore N.
Nagarathna, Raghuram
Nagendra, Hongasamudra R.
Kulkarni, Ravi
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

The "omics" era of research has provided vital information on the genetic and biochemical diversity of individuals. This has lead to the emergence of "personalized medicine," wherein one aims to design specific drugs for individual patients or subtypes of patients. Indeed, the ongoing patent wars on this matter, suggest that personalized medicine represents a major goal for today's pharmaceutical industries.

Author(s): 
Sumantran, Venil N.
Tillu, Girish
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

OBJECTIVE: This is a preliminary report on the development of a scale to measure the symptoms of unmāda (psychosis) attributable to tridosa (metabolic principles) by using the concepts of Ayurvedic medicine. DESIGN: The 67-item unmāda specific symptom scale was developed on the basis of translation of Sanskrit verses describing vātaja (V), pittaja (P), and kaphaja (K) unmāda (specific symptoms of psychosis due to the imbalances of metabolic components) and by taking the opinions of experts (15 Ayurveda experts, 5 psychiatrists, and 5 psychologists).

Author(s): 
Suchitra, Sureshrao P.
Devika, Honagalli S.
Gangadhar, Bangalore N.
Nagarathna, Raghuram
Nagendra, Hongasamudra R.
Kulkarni, Ravi
Publication Title: 
Journal of Alternative and Complementary Medicine (New York, N.Y.)

The "omics" era of research has provided vital information on the genetic and biochemical diversity of individuals. This has lead to the emergence of "personalized medicine," wherein one aims to design specific drugs for individual patients or subtypes of patients. Indeed, the ongoing patent wars on this matter, suggest that personalized medicine represents a major goal for today's pharmaceutical industries.

Author(s): 
Sumantran, Venil N.
Tillu, Girish
Publication Title: 
Journal of the Science of Food and Agriculture

In the emergence of diverse animal life forms, food is the most insistent and pervasive of environmental pressures. As the life sciences begin to understand organisms in genomic detail, evolutionary perspectives provide compelling insights into the results of these dynamic interactions between food and consumer. Such an evolutionary perspective is particularly needed today in the face of unprecedented capabilities to alter the food supply. What should we change?

Author(s): 
Hinde, Katie
German, J. Bruce
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

Use of opioid analgesics for pain management has increased dramatically over the past decade, with corresponding increases in negative sequelae including overdose and death. There is currently no well-validated objective means of accurately identifying patients likely to experience good analgesia with low side effects and abuse risk prior to initiating opioid therapy. This paper discusses the concept of data-based personalized prescribing of opioid analgesics as a means to achieve this goal.

Author(s): 
Bruehl, Stephen
Apkarian, A. Vania
Ballantyne, Jane C.
Berger, Ann
Borsook, David
Chen, Wen G.
Farrar, John T.
Haythornthwaite, Jennifer A.
Horn, Susan D.
Iadarola, Michael J.
Inturrisi, Charles E.
Lao, Lixing
Mackey, Sean
Mao, Jianren
Sawczuk, Andrea
Uhl, George R.
Witter, James
Woolf, Clifford J.
Zubieta, Jon-Kar
Lin, Yu
Publication Title: 
The Journal of Pain: Official Journal of the American Pain Society

Despite the increasing use of opioid analgesics for chronic pain management, it is unclear whether opioid dose escalation leads to better pain relief during chronic opioid therapy. In this study, we retrospectively analyzed clinical data collected from the Massachusetts General Hospital Center for Pain Medicine over a 7-year period. We examined 1) the impact of opioid dose adjustment (increase or decrease) on clinical pain score; 2) gender and age differences in response to opioid therapy; and 3) the influence of clinical pain conditions on the opioid analgesic efficacy.

Author(s): 
Chen, Lucy
Vo, Trang
Seefeld, Lindsey
Malarick, Charlene
Houghton, Mary
Ahmed, Shihab
Zhang, Yi
Cohen, Abigail
Retamozo, Cynthia
St Hilaire, Kristen
Zhang, Vivian
Mao, Jianren
Publication Title: 
PloS One

The detection and treatment of cancer has advanced significantly in the past several decades, with important improvements in our understanding of the fundamental molecular and genetic basis of the disease. Despite these advancements, drug-screening methodologies have remained essentially unchanged since the introduction of the in vitro human cell line screen in 1990.

Author(s): 
Mir, Mustafa
Bergamaschi, Anna
Katzenellenbogen, Benita S.
Popescu, Gabriel
Publication Title: 
Methods in Molecular Biology (Clifton, N.J.)

Psychoneuroimmunology (PNI) may provide the scientific basis for personalized and systems medicine. The exploration of the extensive interactions among psychological and behavioral factors, the nervous system, the immune system, and the endocrine system may help understand the mechanisms underlying health, wellness, and diseases. PNI theories based on systems biology methodologies may contribute to the identification of patient patterns for establishing psychological and physiological profiles for personalized medicine.

Author(s): 
Yan, Qing

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