Inflammation

Publication Title: 
Frontiers in Immunology

There is considerable evidence for the effectiveness of mind-body interventions (MBIs) in improving mental and physical health, but the molecular mechanisms of these benefits remain poorly understood. One hypothesis is that MBIs reverse expression of genes involved in inflammatory reactions that are induced by stress. This systematic review was conducted to examine changes in gene expression that occur after MBIs and to explore how these molecular changes are related to health.

Author(s): 
Buric, Ivana
Farias, Miguel
Jong, Jonathan
Mee, Christopher
Brazil, Inti A.
Publication Title: 
Psychoneuroendocrinology

BACKGROUND AND OBJECTIVES: Practices that include yoga asanas and mindfulness-based stress reduction for the management of stress are increasingly popular; however, the neurobiological effects of these practices on stress reactivity are not well understood. Many studies investigating the effects of such practices fail to include an active control group. Given the frequency with which people are selecting such interventions as a form of self-management, it is important to determine their effectiveness.

Author(s): 
Pascoe, Michaela C.
Thompson, David R.
Ski, Chantal F.
Publication Title: 
PloS One

IMPORTANCE: Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined. OBJECTIVE: To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related immune responses. METHODS: Data sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September 1, 2013.

Author(s): 
Morgan, Nani
Irwin, Michael R.
Chung, Mei
Wang, Chenchen
Publication Title: 
Journal of Psychiatric Research

Stress related disorders such as depression and anxiety are leading sources of disability worldwide, and current treatment methods such as conventional antidepressant medications are not beneficial for all individuals. There is evidence that yoga has mood-enhancing properties possibly related to its inhibitory effects on physiological stress and inflammation, which are frequently associated with affective disorders. However the biological mechanisms via which yoga exerts its therapeutic mood-modulating effects are largely unknown.

Author(s): 
Pascoe, Michaela C.
Bauer, Isabelle E.
Publication Title: 
PloS One

IMPORTANCE: Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined. OBJECTIVE: To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related immune responses. METHODS: Data sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September 1, 2013.

Author(s): 
Morgan, Nani
Irwin, Michael R.
Chung, Mei
Wang, Chenchen
Publication Title: 
Redox Biology

Liver failure induced by systemic inflammatory response (SIRS) is often associated with mitochondrial dysfunction but the mechanism linking SIRS and mitochondria-mediated liver failure is still a matter of discussion. Current hypotheses suggest that causative events could be a drop in ATP synthesis, opening of mitochondrial permeability transition pore, specific changes in mitochondrial morphology, impaired Ca(2+) uptake, generation of mitochondrial reactive oxygen species (mtROS), turnover of mitochondria and imbalance in electron supply to the respiratory chain.

Author(s): 
Kozlov, Andrey V.
Lancaster, Jack R.
Meszaros, Andras T.
Weidinger, Adelheid
Publication Title: 
Journal of Psychiatric Research

Meditation is a popular form of stress management, argued to mediate stress reactivity. However, many studies in this field commonly fail to include an active control group. Given the frequency with which people are selecting meditation as a form of self-management, it is important to validate if the practice is effective in mediating stress-reactivity using well-controlled studies.

Author(s): 
Pascoe, Michaela C.
Thompson, David R.
Jenkins, Zoe M.
Ski, Chantal F.
Publication Title: 
Frontiers in Immunology

There is considerable evidence for the effectiveness of mind-body interventions (MBIs) in improving mental and physical health, but the molecular mechanisms of these benefits remain poorly understood. One hypothesis is that MBIs reverse expression of genes involved in inflammatory reactions that are induced by stress. This systematic review was conducted to examine changes in gene expression that occur after MBIs and to explore how these molecular changes are related to health.

Author(s): 
Buric, Ivana
Farias, Miguel
Jong, Jonathan
Mee, Christopher
Brazil, Inti A.
Publication Title: 
Psychoneuroendocrinology

BACKGROUND AND OBJECTIVES: Practices that include yoga asanas and mindfulness-based stress reduction for the management of stress are increasingly popular; however, the neurobiological effects of these practices on stress reactivity are not well understood. Many studies investigating the effects of such practices fail to include an active control group. Given the frequency with which people are selecting such interventions as a form of self-management, it is important to determine their effectiveness.

Author(s): 
Pascoe, Michaela C.
Thompson, David R.
Ski, Chantal F.
Publication Title: 
Annals of the New York Academy of Sciences

Mindfulness meditation represents a mental training framework for cultivating the state of mindful awareness in daily life. Recently, there has been a surge of interest in how mindfulness meditation improves human health and well-being. Although studies have shown that mindfulness meditation can improve self-reported measures of disease symptomatology, the effect that mindfulness meditation has on biological mechanisms underlying human aging and disease is less clear.

Author(s): 
Black, David S.
Slavich, George M.

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