Inflammation Mediators

Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Helicobacter pylori infection is associated with gastritis, peptic ulcer, and gastric cancer. Due to its high global prevalence and uprising resistance to available antibiotics, efforts are now directed to identify alternative source to treat and prevent associated disorders.

Author(s): 
Zaidi, Syed Faisal
Muhammad, Jibran Sualeh
Shahryar, Saeeda
Usmanghani, Khan
Gilani, Anwarul-Hassan
Jafri, Wasim
Sugiyama, Toshiro
Publication Title: 
Biological & Pharmaceutical Bulletin

Avian pathogenic Escherichia coli (APEC) causes inflammation in multiple organs of chickens called avian colibacillosis, and results in serious economic loss to the chicken industry. Polyphenolic compounds possess a wide range of physiological activities that may contribute to their beneficial effects against inflammation-related diseases. In this study, the curative effect and mechanism of action of the polyphenolic extracts from Punica granatum L. and Terminalia chebula Retz. in chickens challenged with APEC were studied.

Author(s): 
Zhong, Xinlu
Shi, Yaran
Chen, Jiajia
Xu, Jianqing
Wang, Lei
Beier, Ross C.
Hou, Xiaolin
Liu, Fenghua
Publication Title: 
PloS One

Rheumatoid arthritis is a chronic degenerative autoimmune disease characterized by persistent inflammation of synovial membranes, which leads to cartilage destruction and bone erosion. To date, there are no effective therapies to slow the progress of this degenerative condition. Here, we evaluate the anti-arthritic effect of chebulanin, an abundant anti-inflammatory agent isolated from Terminalia chebula, in collagen induced arthritis in DBA/1 mice by intragastric administration.

Author(s): 
Zhao, Yinglan
Liu, Fang
Liu, Yao
Zhou, Dan
Dai, Qing
Liu, Songqing
Publication Title: 
The American Journal of Clinical Nutrition
Author(s): 
Stephensen, Charles B.
Kelley, Darshan S.
Publication Title: 
Nutrition Reviews

The importance of a healthy diet to living well is well recognized. A growing array of experimental, epidemiological, and clinical studies have revealed an association between pro-inflammatory responses and the progression of numerous serious disease states, including the metabolic syndrome, type 2 diabetes, and cardiovascular diseases. Further studies have established a "diet/genetic interaction" that further modulates markers of inflammation, producing both positive and negative effects, depending on the net changes in gene expression.

Author(s): 
Ordovas, JosÈ
Publication Title: 
Clinical chemistry and laboratory medicine: CCLM / FESCC

BACKGROUND: Aging is associated with low-grade elevation of circulating inflammatory markers, leading to increased risk of morbidity and mortality. The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects. METHODS: Within the ZINCAGE study, 957 healthy old subjects (>or=60 years old) from five European countries were recruited.

Author(s): 
Dedoussis, George V.
Kanoni, Stavroula
Mariani, Erminia
Cattini, Luca
Herbein, Georges
Fulop, Tamas
Varin, Audrey
Rink, Lothar
Jajte, Jolanta
Monti, Daniela
Marcellini, Fiorela
Malavolta, Marco
Mocchegiani, Eugenio
Publication Title: 
Depression and Anxiety

Depression has been likened to a state of "accelerated aging," and depressed individuals have a higher incidence of various diseases of aging, such as cardiovascular and cerebrovascular diseases, metabolic syndrome, and dementia. Chronic exposure to certain interlinked biochemical pathways that mediate stress-related depression may contribute to "accelerated aging," cell damage, and certain comorbid medical illnesses.

Author(s): 
Wolkowitz, Owen M.
Epel, Elissa S.
Reus, Victor I.
Mellon, Synthia H.
Publication Title: 
Psychological Medicine

BACKGROUND: Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. METHOD: We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ).

Author(s): 
Dennison, U.
McKernan, D.
Cryan, J.
Dinan, T.
Publication Title: 
Psychiatria Danubina

BACKGROUND: Previous research has shown that metabolic syndrome as well as early life stress can account for immunoactivation (e.g. in the form of altered fibrinogen levels) in patients with major depression. This study aims at assessing the relationship between components of metabolic syndrome, early life stress and fibrinogen levels, taking the severity of depression into consideration. SUBJECTS AND METHODS: Measures of early life stress and signs of metabolic syndrome were collected in 58 adult inpatients diagnosed with depression.

Author(s): 
Zeugmann, Sara
Quante, Arnim
Popova-Zeugmann, Louchka
Kˆssler, Wolfgang
Heuser, Isabella
Anghelescu, Ion
Publication Title: 
BMC genomics

BACKGROUND: Regular smoking is associated with a wide variety of syndromes with prominent inflammatory components such as cancer, obesity and type 2 diabetes. Heavy regular smoking is also associated with changes in the DNA methylation of peripheral mononuclear cells. However, in younger smokers, inflammatory epigenetic findings are largely absent which suggests the inflammatory response(s) to smoking may be dose dependent.

Author(s): 
Dogan, Meeshanthini V.
Shields, Bridget
Cutrona, Carolyn
Gao, Long
Gibbons, Frederick X.
Simons, Ronald
Monick, Martha
Brody, Gene H.
Tan, Kai
Beach, Steven R. H.
Philibert, Robert A.

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