Inflammation

Publication Title: 
Journal of Clinical Pathology
Author(s): 
Ghosh, M. L.
Hudson, G.
Blackburn, E. K.
Publication Title: 
PloS One

BACKGROUND: Depression is associated with an unusually high rate of aging-related illnesses and early mortality. One aspect of "accelerated aging" in depression may be shortened leukocyte telomeres. When telomeres critically shorten, as often occurs with repeated mitoses or in response to oxidation and inflammation, cells may die. Indeed, leukocyte telomere shortening predicts early mortality and medical illnesses in non-depressed populations.

Author(s): 
Wolkowitz, Owen M.
Mellon, Synthia H.
Epel, Elissa S.
Lin, Jue
Dhabhar, Firdaus S.
Su, Yali
Reus, Victor I.
Rosser, Rebecca
Burke, Heather M.
Kupferman, Eve
Compagnone, Mariana
Nelson, J. Craig
Blackburn, Elizabeth H.
Publication Title: 
Brain, Behavior, and Immunity

Cognitive and affective responses to acute stress influence pro-inflammatory cytokine reactivity, and peripheral cytokines (particularly interleukin-1 beta (IL-1?)), can act on the brain to promote depressive symptoms. It is unknown whether acute stress-induced changes in positive affect and cognitions (POS) and pro-inflammatory reactivity predict future depressive symptoms. We examined acute stress responses among women, to determine prospective predictors of depressive symptoms.

Author(s): 
Aschbacher, K.
Epel, E.
Wolkowitz, O. M.
Prather, A. A.
Puterman, E.
Dhabhar, F. S.
Publication Title: 
Journal of Psychiatric Research

Systemic inflammation is proposed as a putative mechanism underlying the link between poor sleep and cardiovascular disease. The aim of present study was to investigate the cross-sectional and prospective associations of self-reported sleep quality with biomarkers of inflammation and coagulation implicated in coronary heart disease (CHD) and to explore whether these associations differed between men and women.

Author(s): 
Prather, Aric A.
Epel, Elissa S.
Cohen, Beth E.
Neylan, Thomas C.
Whooley, Mary A.
Publication Title: 
Brain, Behavior, and Immunity

Chronic inflammation and oxidative stress have been implicated in the pathophysiology of Major Depressive Disorder (MDD), as well as in a number of chronic medical conditions. The aim of this study was to examine the relationship between peripheral inflammatory and oxidative stress markers in un-medicated subjects with MDD compared to non-depressed healthy controls and compared to subjects with MDD after antidepressant treatment. We examined the relationships between IL-6, IL-10, and the IL-6/IL-10 inflammatory ratio vs.

Author(s): 
Rawdin, B. J.
Mellon, S. H.
Dhabhar, F. S.
Epel, E. S.
Puterman, E.
Su, Y.
Burke, H. M.
Reus, V. I.
Rosser, R.
Hamilton, S. P.
Nelson, J. C.
Wolkowitz, O. M.
Publication Title: 
Neuroscience and Biobehavioral Reviews

Anxiety disorders increase risk for the early development of several diseases of aging. Elevated inflammation, a common risk factor across diseases of aging, may play a key role in the relationship between anxiety and physical disease. However, the neurobiological mechanisms linking anxiety with elevated inflammation remain unclear. In this review, we present a neurobiological model of the mechanisms by which anxiety promotes inflammation.

Author(s): 
O'Donovan, Aoife
Slavich, George M.
Epel, Elissa S.
Neylan, Thomas C.
Publication Title: 
PloS One

BACKGROUND: Depression is associated with an unusually high rate of aging-related illnesses and early mortality. One aspect of "accelerated aging" in depression may be shortened leukocyte telomeres. When telomeres critically shorten, as often occurs with repeated mitoses or in response to oxidation and inflammation, cells may die. Indeed, leukocyte telomere shortening predicts early mortality and medical illnesses in non-depressed populations.

Author(s): 
Wolkowitz, Owen M.
Mellon, Synthia H.
Epel, Elissa S.
Lin, Jue
Dhabhar, Firdaus S.
Su, Yali
Reus, Victor I.
Rosser, Rebecca
Burke, Heather M.
Kupferman, Eve
Compagnone, Mariana
Nelson, J. Craig
Blackburn, Elizabeth H.
Publication Title: 
Journal of Anatomy
Author(s): 
Ghosh, M. L.
Hudson, G.
Blackburn, E. K.
Publication Title: 
PloS One

BACKGROUND: Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells with critically short telomeres produce pro-inflammatory factors. However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction.

Author(s): 
O'Donovan, Aoife
Pantell, Matthew S.
Puterman, Eli
Dhabhar, Firdaus S.
Blackburn, Elizabeth H.
Yaffe, Kristine
Cawthon, Richard M.
Opresko, Patricia L.
Hsueh, Wen-Chi
Satterfield, Suzanne
Newman, Anne B.
Ayonayon, Hilsa N.
Rubin, Susan M.
Harris, Tamara B.
Epel, Elissa S.
Health Aging and Body Composition Study
Publication Title: 
PloS One

BACKGROUND: Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells with critically short telomeres produce pro-inflammatory factors. However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction.

Author(s): 
O'Donovan, Aoife
Pantell, Matthew S.
Puterman, Eli
Dhabhar, Firdaus S.
Blackburn, Elizabeth H.
Yaffe, Kristine
Cawthon, Richard M.
Opresko, Patricia L.
Hsueh, Wen-Chi
Satterfield, Suzanne
Newman, Anne B.
Ayonayon, Hilsa N.
Rubin, Susan M.
Harris, Tamara B.
Epel, Elissa S.
Health Aging and Body Composition Study

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