Inflammation

Publication Title: 
Alimentary Pharmacology & Therapeutics

Alterations in motility, secretion and visceral sensation are hallmarks of irritable bowel syndrome. As all of these aspects of gastrointestinal function involve serotonin signalling between enterochromaffin cells and sensory nerve fibres in the mucosal layer of the gut, potential alterations in mucosal serotonin signalling have been explored as a possible mechanism of altered function and sensation in irritable bowel syndrome. Literature related to intestinal serotonin signalling in normal and pathophysiological conditions has been searched and summarized.

Author(s): 
Mawe, G. M.
Coates, M. D.
Moses, P. L.
Publication Title: 
Psychological Medicine

BACKGROUND: Recent work suggests that epigenetic differences may be associated with psychiatric disorders. Here we investigate, in a community-based sample, whether methylation profiles distinguish between individuals with and without lifetime depression. We also investigate the physiologic consequences that may be associated with these profiles.

Author(s): 
Uddin, M.
Koenen, K. C.
Aiello, A. E.
Wildman, D. E.
de los Santos, R.
Galea, S.
Publication Title: 
Psychological Bulletin

Among people exposed to major psychological stressors in early life, there are elevated rates of morbidity and mortality from chronic diseases of aging. The most compelling data come from studies of children raised in poverty or maltreated by their parents, who show heightened vulnerability to vascular disease, autoimmune disorders, and premature mortality. These findings raise challenging theoretical questions. How does childhood stress get under the skin, at the molecular level, to affect risk for later diseases?

Author(s): 
Miller, Gregory E.
Chen, Edith
Parker, Karen J.
Publication Title: 
Psychological Medicine

BACKGROUND: Increasing evidence indicates that childhood trauma is a risk factor for schizophrenia and patients with this syndrome have a pro-inflammatory phenotype. We tested the hypothesis that the pro-inflammatory phenotype in schizophrenia is associated with childhood trauma and that patients without a history of such trauma have a similar immune profile to healthy controls. METHOD: We recruited 40 schizophrenia patients and 40 controls, all of whom completed the Childhood Trauma Questionnaire (CTQ).

Author(s): 
Dennison, U.
McKernan, D.
Cryan, J.
Dinan, T.
Publication Title: 
Nature Reviews. Cardiology

The close, bidirectional relationship between depression and cardiovascular disease is well established. Major depression is associated with an increased risk of coronary artery disease and acute cardiovascular sequelae, such as myocardial infarction, congestive heart failure, and isolated systolic hypertension. Morbidity and mortality in patients with cardiovascular disease and depression are significantly higher than in patients with cardiovascular disease who are not depressed.

Author(s): 
Nemeroff, Charles B.
Goldschmidt-Clermont, Pascal J.
Publication Title: 
PloS One

BACKGROUND: The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD). In this context, functional polymorphisms of the ACE gene have been linked to depression, to antidepressant treatment response, to ACE serum concentrations, as well as to hypertension, myocardial infarction and CVD risk markers.

Author(s): 
Zill, Peter
Baghai, Thomas C.
Sch¸le, Cornelius
Born, Christoph
Fr¸st¸ck, Clemens
B¸ttner, Andreas
Eisenmenger, Wolfgang
Varallo-Bedarida, Gabriella
Rupprecht, Rainer
Mˆller, Hans-J¸rgen
Bondy, Brigitta
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry

As for other major psychoses, the etiology of schizophrenia still remains poorly understood, involving genetic and epigenetic mechanisms, as well as environmental contributions. In addition, immune alterations have been widely reported in schizophrenic patients, involving both the unspecific and specific pathways of the immune system, and suggesting that infectious/autoimmune processes play an important role in the etiopathogenesis of the disorder.

Author(s): 
Altamura, A. Carlo
Pozzoli, Sara
Fiorentini, Alessio
Dell'osso, Bernardo
Publication Title: 
Schizophrenia Bulletin

DNA methylation, one of the main epigenetic mechanisms to regulate gene expression, appears to be involved in the development of schizophrenia (SZ). In this study, we investigated 7562 DNA methylation markers in blood from 98 SZ patients and 108 healthy controls. A linear regression model including age, gender, race, alcohol, nicotine and cannabis use status, and diagnosis was implemented to identify C-phosphate-G (CpG) sites significantly associated with diagnosis. These CpG sites were further validated using an independent data set.

Author(s): 
Liu, Jingyu
Chen, Jiayu
Ehrlich, Stefan
Walton, Esther
White, Tonya
Perrone-Bizzozero, Nora
Bustillo, Juan
Turner, Jessica A.
Calhoun, Vince D.
Publication Title: 
Psychoneuroendocrinology

This mini-review refers to recent findings on psychobiological long-term consequences of childhood trauma and adverse living conditions. The continuum of trauma-provoked aftermath reaches from healthy adaptation with high resilience, to severe maladjustment with co-occurring psychiatric and physical pathologies in children, adolescents and adults. There is increasing evidence of a strong interconnectivity between genetic dispositions, epigenetic processes, stress-related hormonal systems and immune parameters in all forms of (mal)-adjustment to adverse living conditions.

Author(s): 
Ehlert, Ulrike
Publication Title: 
Pharmacological reports: PR

Depression has been conceptualized as a disorder driven by immuno-inflammatory pathways and oxidative and nitrosative stress. These factors couple to the induction of neuroregulatory tryptophan catabolites via the activation of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO). Oxidative damage to neoepitopes increases autoimmune responses, changing the nature of the neural substrate of recurrent depression, which leads to neuroprogression and drives treatment resistance. A number of pro-inflammatory cytokines are linked to these processes.

Author(s): 
Anderson, George
Kubera, Marta
Duda, Weronika
Laso?, W?adys?aw
Berk, Michael
Maes, Michael

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