Influenza A Virus, H1N1 Subtype

Publication Title: 
Journal of Medical Internet Research

BACKGROUND: As the incidence of H1N1 increases, the lay public may turn to the Internet for information about natural supplements for prevention and treatment. OBJECTIVE: Our objective was to identify and characterize websites that provide information about herbal and natural supplements with information about H1N1 and to examine trends in the public's behavior in searching for information about supplement use in preventing or treating H1N1.

Author(s): 
Hill, Shawndra
Mao, Jun
Ungar, Lyle
Hennessy, Sean
Leonard, Charles E.
Holmes, John
Publication Title: 
Revue Medicale Suisse

This manuscript reviews the main vaccine safety concerns that have limited the confidence of the population vis-a-vis influenza A(H1N1) vaccines and disturbed health professionals: A hasty development process? Excessively strong adjuvants? Notoriously toxic substances such as squalene and mercury salts? High risks of Guillain-Barre syndrome or auto-immune diseases? Deaths and other severe problems following immunization?

Author(s): 
Siegrist, Claire-Anne
Publication Title: 
Vaccine

Influenza infection is a major clinical problem and Echinacea purpurea, a widely consumed botanical product, is purported to alter the course of respiratory infections including influenza. Mice infected with WSN influenza A and treated with E. purpurea polysaccharide extract had less weight loss than untreated mice but similar pulmonary viral titers. Echinacea-treated mice had lower systemic and pulmonary KC and IL-10 levels and lower systemic IFN-gamma levels following influenza infection. These suggest that E.

Author(s): 
Fusco, Dahlene
Liu, Xinyan
Savage, Caroline
Taur, Ying
Xiao, Weilie
Kennelly, Edward
Yuan, Jianda
Cassileth, Barrie
Salvatore, Mirella
Papanicolaou, Genovefa A.
Publication Title: 
European Journal of Clinical Nutrition

BACKGROUND/OBJECTIVES: Live-attenuated influenza vaccine (LAIV) protects against influenza by mucosal activation of the immune system. Studies in animals and adults have demonstrated that probiotics improve the immune response to mucosally delivered vaccines. We hypothesized that Lactobacillus GG (LGG) would function as an immune adjuvant to increase rates of seroconversion after LAIV administration. SUBJECTS/METHODS: We conducted a randomized double-blind placebo-controlled pilot study to determine whether LGG improved rates of seroconversion after administration of LAIV.

Author(s): 
Davidson, L. E.
Fiorino, A.-M.
Snydman, D. R.
Hibberd, P. L.
Publication Title: 
Journal of Medical Internet Research

BACKGROUND: As the incidence of H1N1 increases, the lay public may turn to the Internet for information about natural supplements for prevention and treatment. OBJECTIVE: Our objective was to identify and characterize websites that provide information about herbal and natural supplements with information about H1N1 and to examine trends in the public's behavior in searching for information about supplement use in preventing or treating H1N1.

Author(s): 
Hill, Shawndra
Mao, Jun
Ungar, Lyle
Hennessy, Sean
Leonard, Charles E.
Holmes, John
Publication Title: 
PloS One

Hypericumperforatum (H. perforatum) ethanol extract has been found to inhibit lipopolysaccharide-induced production of inflammatory mediators and cytokines in cultured macrophages. Therefore, it may be able to protect the host from excessive inflammation during viral infection. In the current study, the immune-regulatory effect of H. perforatum extract was evaluated in A549 lung epithelial cells and BALB/c mice exposed to Influenza A/PR/8/34 H1N1 virus.

Author(s): 
Huang, Nan
Singh, Navrozedeep
Yoon, Kyoungjin
Loiacono, Christina M.
Kohut, Marian L.
Birt, Diane F.
Publication Title: 
Healthcare Quarterly (Toronto, Ont.)

The perceived safety of vaccination is an important explanatory factor for vaccine uptake and, consequently, for rates of illness and death. The objectives of this study were (1) to evaluate Canadian attitudes around the safety of the H1N1 vaccine during the fall 2009 influenza pandemic and (2) to consider how public health communications can leverage the Internet to counteract, in real time, anti-vaccine sentiment. We surveyed a random sample of 175,257 Canadian web users from October 27 to November 19, 2009, about their perceptions of the safety of the HINI vaccine.

Author(s): 
Seeman, Neil
Ing, Alton
Rizo, Carlos
Publication Title: 
Australian Family Physician

BACKGROUND: The 2009/A/H1N1 influenza vaccination campaign was managed mainly by general practitioners (GPs); however, little is known about the challenges GPs encountered during the vaccination campaign. AIM: To analyse the challenges GPs encountered during the 2009/A/H1N1 vaccination campaign. METHODS: In-depth, semi-structured qualitative interviews were conducted with GPs in Australia, Israel and England, and subjected to thematic analysis. RESULTS: GPs experienced different levels of autonomy when organising vaccinations in clinics.

Author(s): 
Kunin, Marina
Engelhard, Dan
Thomas, Shane
Ashworth, Mark
Piterman, Leon
Publication Title: 
Australian Family Physician

BACKGROUND: The 2009/A/H1N1 influenza vaccination campaign was managed mainly by general practitioners (GPs); however, little is known about the challenges GPs encountered during the vaccination campaign. AIM: To analyse the challenges GPs encountered during the 2009/A/H1N1 vaccination campaign. METHODS: In-depth, semi-structured qualitative interviews were conducted with GPs in Australia, Israel and England, and subjected to thematic analysis. RESULTS: GPs experienced different levels of autonomy when organising vaccinations in clinics.

Author(s): 
Kunin, Marina
Engelhard, Dan
Thomas, Shane
Ashworth, Mark
Piterman, Leon
Publication Title: 
Molecules (Basel, Switzerland)

The fruit of Chaenomeles speciosa is a traditional Chinese medicine used for the treatment of dyspepsia and various inflammatory diseases. In the present study, we evaluated the potential radical scavenging capacity, and activity against nitrous oxide, inflammatory cytokines production and neuramindase (NA) of its isolates.

Author(s): 
Zhang, Li
Cheng, Yong-Xian
Liu, Ai-Lin
Wang, Hai-Di
Wang, Ya-Ling
Du, Guan-hua

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