Inhibitor of Differentiation Proteins

Publication Title: 
Aging Cell

Fetal cardiomyocytes have been proposed as a potential source of cell-based therapy for heart failure. This study examined cellular senescence in cultured human fetal ventricular cardiomyocytes (HFCs). HFCs were isolated and identified by immunocytochemistry and RT-PCR. Cells were found to senesce after 20-25 population doublings, as determined by growth arrest, morphological changes and senescence-associated beta-galactosidase activity. Using the telomeric repeat amplification protocol assay, telomerase activity was undetectable in primary HFCs.

Author(s): 
Ball, Andrew J.
Levine, Fred
Publication Title: 
Journal of the American Academy of Child and Adolescent Psychiatry

OBJECTIVES: To determine whether epigenetic markers predict dimensional ratings of depression in maltreated children. METHOD: A genome-wide methylation study was completed using the Illumina 450K BeadChip array in 94 maltreated and 96 healthy nontraumatized children with saliva-derived DNA. The 450K BeadChip does not include any methylation sites in the exact location as sites in candidate genes previously examined in the literature, so†a†test†for replication of prior research findings was not feasible.

Author(s): 
Weder, Natalie
Zhang, Huiping
Jensen, Kevin
Yang, Bao Zhu
Simen, Arthur
Jackowski, Andrea
Lipschitz, Deborah
Douglas-Palumberi, Heather
Ge, Margrat
Perepletchikova, Francheska
O'Loughlin, Kerry
Hudziak, James J.
Gelernter, Joel
Kaufman, Joan
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