Injections, Intraperitoneal

Publication Title: 
Arthritis and Rheumatism

OBJECTIVE: Chebulagic acid (CHE) from the immature seeds of Terminalia chebula was identified from a natural product library as a potent suppressor of T cell activity. This study examined the effectiveness of CHE against the onset and progression of collagen-induced arthritis (CIA) in mice. METHODS: Arthritis was induced in DBA/1J mice by subcutaneous immunization with bovine type II collagen on days 0 and 21. CHE was administered intraperitoneally for 3 weeks, either as prophylaxis (10 or 20 mg/kg) before disease onset or as therapy (20 mg/kg) after disease onset.

Author(s): 
Lee, Sang-Ik
Hyun, Pung-Mi
Kim, Seung-Hyung
Kim, Kyoung-Shin
Lee, Sang-Keun
Kim, Byoung-Soo
Maeng, Pil Jae
Lim, Jong-Soon
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics
Author(s): 
Peters, M. A.
Publication Title: 
Journal of Toxicology and Environmental Health

A 24-hr inhalation of 1,1,1-tricholoroethane (methylchloroform), 3,000 ppm, reduced pentobarbital hypnosis and increased hexobarbitaloxidation by the 9,000 x g liver supernatant fraction in male mice. On the other hand, an ip injection of methylchloroform, l ml/kg, increased the duration of pentobarbital hypnosis and reduced hexobarbital metabolism by the liver microsomal enzymes. The potentioating effect of methylchloroform on pentobarbital hypnosis as diminished when it was diluted with olive oil, but was markedly enhanced when diluted with dimethysusoxide (DMSO) before injection.

Author(s): 
Shan, H. C.
Lal, H.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

The influence of intraperitoneal administration of disulfiram on the serotonin (5HT) turnover and the brain sensitivity to barbiturates were investigated in rats. Treatment of the animals with 200 mg/kg disulfiram resulted in the prolongation of duration of barbiturate-induced hypnosis. This indication and increment of the brain sensitivity to barbiturates after disulfiram treatment. Under the identical condition, disulfiram caused both the reduction of turnover of 5HT and the elevation of 5HT levels, although this effect was less potent than that of phenobarbital.

Author(s): 
Minegishi, A.
Fukumori, R.
Satoh, T.
Kitagawa, H.
Yanaura, S.
Publication Title: 
Research Communications in Chemical Pathology and Pharmacology

Within one day after a single IP injection of cedar sesquiterpenes into mice, pentobarbital sleeptime was reduced by 40%. The estimated ED50 is 50 mg terpenes/kg body weight. The mice recovered from this terpene-induced reduction in the strength of hypnosis within 6 days after the terpene injection. The potency of the terpenes, the rapidity of their action, and the duration of their effectiveness in modulating a drug response suggest their usefulness as a pharmacological tool.

Author(s): 
Malkinson, A. M.
Shere, W. C.
Publication Title: 
Pharmacology, Biochemistry, and Behavior

Long Sleep (LS) and Short Sleep (SS) mice were used in this study to investigate the interaction between ethanol and taurine. Sleep time (hypnosis) was selected as an index of ethanol-induced central nervous system depression. In order to achieve a similar degree of central nervous system depression with ethanol, SS and LS mice received 5.3 and 3.0 g/kg, IP, of ethanol, respectively.

Author(s): 
Ferko, A. P.
Bobyock, E.
Publication Title: 
Anesthesiology

Dexmedetomidine, a highly selective and potent alpha-2 adrenoceptor agonist, reduces halothane anesthetic requirements by over 90% in rats. The present study examined whether dexmedetomidine produces a hypnotic-anesthetic action in rats. Dexmedetomidine induced a hypnotic-anesthetic state in rats characterized by loss of righting reflex at doses greater than or equal to 0.1 mg/kg. This response was dose-dependent between 0.1 and 3 mg/kg.

Author(s): 
Doze, V. A.
Chen, B. X.
Maze, M.
Publication Title: 
Pharmacology, Biochemistry, and Behavior

The potential influence of the neurosteroid pregnenolone sulfate (PrS) on barbiturate-induced hypnosis was tested in rats. PrS, when injected intracerebroventricularly or intraperitoneally, significantly shortened the sleep-time produced by pentobarbital. The results suggest an important physiological and pharmacological role for PrS in the regulation of CNS excitability.

Author(s): 
Majewska, M. D.
Bluet-Pajot, M. T.
Robel, P.
Baulieu, E. E.
Publication Title: 
Anesthesiology

Previously, we demonstrated that dexmedetomidine, an alpha 2 agonist, produces a hypnotic-anesthetic response in rats via activation of central alpha 2 adrenoceptors and that this response could be enhanced by the alpha 1 antagonist prazosin. In the current experiment we investigated whether central alpha 1 adrenoceptor stimulation antagonizes the alpha 2 adrenoceptor-mediated hypnotic response.

Author(s): 
Guo, T. Z.
Tinklenberg, J.
Oliker, R.
Maze, M.
Publication Title: 
Archiv Der Pharmazie

The possibility of the preparation of some ester derivatives of dimethylxanthines from 1-theobromine- and 7-theophylline acetic acids and 7-(2-hydroxyethyl)-theophylline by DCC/DMAP-mediated esterification under mild conditions was studied. The structures of the compounds synthesized and by products isolated were demonstrated by microanalyses, UV-, IR-, and 1H NMR data. Acute toxicity assessment of the compounds on mice showed that compounds 4, 5, 6, and 7 are less toxic than aminophylline.

Author(s): 
Peikov, P.
Danchev, N.
Zlatkov, A.
Ivanov, D.
Belcheva, N.

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