Insulin-Like Growth Factor Binding Protein 4

Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

Over-consumption of dietary fat has been suggested to promote the development and progression of prostate cancer in men. The present study was conducted to answer the following questions: (a) Can dietary fat reduction decrease tumor growth rates of Los Angeles prostate cancer (LAPC)-4 xenografts in severe combined immunodeficient (SCID) mice independent of total caloric intake? and (b) Is the insulin-like growth factor (IGF) axis involved in the effects of dietary fat on LAPC-4 tumor growth in SCID mice?

Author(s): 
Ngo, Tung H.
Barnard, R. James
Cohen, Pinchas
Freedland, Stephen
Tran, Chris
deGregorio, Frank
Elshimali, Yahya I.
Heber, David
Aronson, William J.
Publication Title: 
Journal of Bone and Mineral Research: The Official Journal of the American Society for Bone and Mineral Research

Efficient osteogenic differentiation and bone formation from mesenchymal stem cells (MSCs) should have clinical applications in treating nonunion fracture healing. MSCs are adherent bone marrow stromal cells that can self-renew and differentiate into osteogenic, chondrogenic, adipogenic, and myogenic lineages. We have identified bone morphogenetic protein 9 (BMP-9) as one of the most osteogenic BMPs. Here we investigate the effect of insulin-like growth factor 2 (IGF-2) on BMP-9-induced bone formation. We have found that endogenous IGF-2 expression is low in MSCs.

Author(s): 
Chen, Liang
Jiang, Wei
Huang, Jiayi
He, Bai-Cheng
Zuo, Guo-Wei
Zhang, Wenli
Luo, Qing
Shi, Qiong
Zhang, Bing-Qiang
Wagner, Eric R.
Luo, Jinyong
Tang, Min
Wietholt, Christian
Luo, Xiaoji
Bi, Yang
Su, Yuxi
Liu, Bo
Kim, Stephanie H.
He, Connie J.
Hu, Yawen
Shen, Jikun
Rastegar, Farbod
Huang, Enyi
Gao, Yanhong
Gao, Jian-Li
Zhou, Jian-Zhong
Reid, Russell R.
Luu, Hue H.
Haydon, Rex C.
He, Tong-Chuan
Deng, Zhong-Liang
Publication Title: 
European Journal of Endocrinology / European Federation of Endocrine Societies

OBJECTIVE: Decreased levels of GH and total IGF-I have been reported in obesity. It has been hypothesized that increased free (biologically active) IGF-I levels generated from IGF-binding protein (IGFBP) protease activity could be the mechanism for the low GH release in dieting obese subjects. However, no published data exist on free IGF-I levels, acid labile subunit (ALS), or IGFBP protease activity in relation to GH release during a hypocaloric diet.

Author(s): 
Rasmussen, Michael Højby
Juul, Anders
Kjems, Lise Lund
Hilsted, Jannik
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