Insulin Resistance

Publication Title: 
Alternative Therapies in Health and Medicine

Cardiovascular disease (CVD) is the leading cause of death and disability in the industrialized world, and its prevalence is rapidly increasing among developing nations. The increasing global prevalence of CVD reflects in part the concurrent rise in insulin resistance, obesity, dyslipidemia, and other atherogenic changes associated with insulin resistance syndrome (IRS). Evidence suggests that chronic stress and related psychosocial factors also play an important role in the development and progression of IRS-related states and ultimately, in the pathogenesis of CVD.

Author(s): 
Innes, Kim E.
Vincent, Heather K.
Taylor, Ann Gill
Publication Title: 
Evidence-Based Complementary and Alternative Medicine: eCAM

There is growing evidence that yoga may offer a safe and cost-effective intervention for Type 2 Diabetes mellitus (DM 2). However, systematic reviews are lacking. This article critically reviews the published literature regarding the effects of yoga-based programs on physiologic and anthropometric risk profiles and related clinical outcomes in adults with DM 2. We performed a comprehensive literature search using four computerized English and Indian scientific databases.

Author(s): 
Innes, Kim E.
Vincent, Heather K.
Publication Title: 
Complementary Therapies in Medicine

OBJECTIVES: To summarize and critically evaluate the evidence available from clinical trials (CTs) of qigong for patients with type 2 diabetes. METHODS: We have searched the literature using 15 databases from their respective inceptions through March 2009 without language restrictions. Risk of bias was assessed using Cochrane criteria. RESULTS: Nine CTs, which included three randomized clinical trials (RCTs), one controlled clinical trial (CCT) and five uncontrolled observational studies (UOSs), met our inclusion criteria.

Author(s): 
Lee, Myeong Soo
Chen, Kevin W.
Choi, Tae-Young
Ernst, Edzard
Publication Title: 
Diabetes & Metabolic Syndrome

STATEMENT OF THE PROBLEM: Complementary and alternative medicines have been increasingly used as a co adjuvant treatment of chronic diseases, including diabetes mellitus. However, very little is known, especially in western countries, about its effects in the treatment of type 2 diabetes mellitus (T2DM). The purpose of this review was to summarize and critically evaluate clinical evidences regarding the effect of Chinese therapeutic exercises (Qigong) in the treatment of T2DM.

Author(s): 
Freire, Marcos Dantas Moraes
Alves, Cresio
Publication Title: 
BioFactors (Oxford, England)

The thiazolidinedione (TZDs) class of drugs are very effective for the treatment of type 2 diabetes mellitus (T2DM). But due to the adverse effects of synthetic TZDs, their use is strictly regulated. The therapeutic actions of TZDs are mediated via modulation of peroxisome proliferator-activated receptor gamma (PPAR?). Naturally occurring PPAR? modulators are more desirable as they lack the serious adverse effects caused by TZDs. This has prompted the exploitation of medicinal plants used in traditional medicine, for their potential PPAR? activity.

Author(s): 
Shyni, Gangadharan Leela
Kavitha, Sasidharan
Indu, Sasidharan
Arya, Anil Das
Anusree, Sasidharan Suseela
Vineetha, Vadavanath Prabhakaran
Vandana, Sankar
Sundaresan, Andikannu
Raghu, Kozhiparambil Gopalan
Publication Title: 
Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics

The potential link between aging and insulin signaling has attracted substantial attention since several decades ago, on the basis of evidence including age-related increase in incidence of insulin resistance, insulin resistance and type 2 diabetes in accelerated aging syndromes and lifespan extension by caloric restriction in rodents. In addition, the intensive investigations in C.

Author(s): 
Kaneki, M.
Publication Title: 
Cell Cycle (Georgetown, Tex.)

Although it has been known since 1917 that calorie restriction (CR) decelerates aging, the topic remains highly controversial. What might be the reason? Here I discuss that the anti-aging effect of CR rules out accumulation of DNA damage and failure of maintenance as a cause of aging. Instead, it suggests that aging is driven in part by the nutrient-sensing TOR (target of rapamycin) network. CR deactivates the TOR pathway, thus slowing aging and delaying diseases of aging.

Author(s): 
Blagosklonny, Mikhail V.
Publication Title: 
Experimental Gerontology

Restriction of dietary methionine by 80% slows the progression of aged-related diseases and prolongs lifespan in rodents. A salient feature of the methionine restriction phenotype is the significant reduction of adipose tissue mass, which is associated with improvement of insulin sensitivity. These beneficial effects of MR involve a host of metabolic adaptations leading to increased mitochondrial biogenesis and function, elevated energy expenditure, changes of lipid and carbohydrate homeostasis, and decreased oxidative damage and inflammation.

Author(s): 
Perrone, Carmen E.
Malloy, Virginia L.
Orentreich, David S.
Orentreich, Norman
Publication Title: 
Experimental Gerontology

Starting from young to very old subjects, aging is associated with a progressive remodeling. Such an age-dependent remodeling process mainly affects anthropometrics, endocrine and thus, also metabolic factors. Interestingly, it occurs in some individuals successfully, while in others unsuccessfully. Centenarians in good health conditions are a very selected group of subjects representing an exceptional condition. Why the centenarians reach the extreme human life span is still unknown.

Author(s): 
Barbieri, M.
Gambardella, A.
Paolisso, G.
Varricchio, M.
Publication Title: 
Journal of the American Geriatrics Society

OBJECTIVES: To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity. DESIGN: Case-control study. SETTING: A university hospital in Leiden, the Netherlands. PARTICIPANTS: One hundred twenty-one offspring of nonagenarian siblings, who were enriched for familial factors promoting longevity, and 113 of their partners. No subject had diabetes mellitus. MEASUREMENTS: Prevalence of metabolic syndrome was determined according to the criteria of the Third Report of the National Cholesterol Education Program.

Author(s): 
Rozing, Maarten P.
Westendorp, Rudi G. J.
de Craen, Anton J. M.
Frˆlich, Marijke
de Goeij, Moniek C. M.
Heijmans, Bastiaan T.
Beekman, Marian
Wijsman, Carolien A.
Mooijaart, Simon P.
Blauw, Gerard-Jan
Slagboom, P. Eline
van Heemst, Diana
Leiden Longevity Study Group

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