Integrins

Publication Title: 
Acupuncture & Electro-Therapeutics Research

The effects, on normal human subjects, of 3 minutes exposure to electro-magnetic fields (EMFs) emitted from: A) personal computers, B) color television sets, or C) microwave-ovens, or cellular phones were compared by placing the same large sheet of aluminum foil with a square hole or rectangular band-shaped hole at the chest level (or at the side of the head with the cellular phone), with or without grounding the aluminum foil, using the Bi-Digital O-Ring Test Dysfunction Localization and Molecular Identification Methods with cancer related substances (i.e., Oncogen C-fos Ab2 and mercury in

Author(s): 
Omura, Y.
Losco, M.
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Two VLA proteins (or beta 1 integrins; originally called very late activation antigens) that bind to distinct determinants on fibronectin (FN) are increased on activated immune or memory T cells. VLA-4 binds to the peptide sequence Gly-Pro-Glu-Ile-Leu-Asp-Val-Pro-Ser-Thr (GPEILDVPST in single-letter code) on the alternatively spliced CS-1 form of FN, whereas VLA-5 binds to an Arg-Gly-Asp sequence found on all forms of FN.

Author(s): 
Ferguson, T. A.
Mizutani, H.
Kupper, T. S.
Publication Title: 
Cancer Research

Cell adhesion and spreading is a crucial step in the metastatic cascade of cancer cells, and interruption of this step is considered to be a logical strategy for prevention and treatment of tumor metastasis. Emodin is the major active component of the rhizome of Rheum palmatum L., with known anticancer activities. Here, we first found that emodin significantly inhibited cell adhesion of various human cancer cells.

Author(s): 
Huang, Qing
Shen, Han-Ming
Shui, Guanghou
Wenk, Markus R.
Ong, Choon-nam
Publication Title: 
Atherosclerosis

Chlorotyrosine is an oxidative product of hypochlorous acid and l-tyrosine, and is considered as a biomarker for oxidative stress and cardiovascular disease. However, it is not clear whether chlorotyrosine could directly contribute to vascular pathogenesis. In this study, we investigated the effect and potential mechanisms of chlorotyrosine on human aortic smooth muscle cell (AoSMC) migration. With Boyden chamber and wound healing assays, chlorotyrosine significantly increased AoSMC migration in a concentration- and time-dependent manner.

Author(s): 
Mu, Hong
Wang, Xinwen
Lin, Peter H.
Yao, Qizhi
Chen, Changyi
Publication Title: 
Biochimica Et Biophysica Acta

Nitrotyrosine is a new biomarker of atherosclerosis and inflammation. The objective of this study was to determine the direct effects of free nitrotyrosine on human aortic smooth muscle cell (AoSMC) migration and molecular mechanisms. By a modified Boyden chamber assay, nitrotyrosine significantly increased AoSMC migration in a concentration-dependent manner. For example, nitrotyrosine at 300 nM increased AoSMC migration up to 152% compared with l-tyrosine-treated control cells (P<0.01). Cell wound healing assay confirmed this effect.

Author(s): 
Mu, Hong
Wang, Xinwen
Lin, Peter
Yao, Qizhi
Chen, Changyi
Publication Title: 
Blood

Cysteinyl leukotriene (cysLT) overproduction is a hallmark of aspirin-exacerbated respiratory disease (AERD), but its mechanism is poorly understood. Because adherent platelets can convert the leukocyte-derived precursor leukotriene (LT)A(4) to LTC(4), the parent cysLT, through the terminal enzyme LTC(4) synthase, we investigated the contribution of platelet-dependent transcellular cysLT production in AERD.

Author(s): 
Laidlaw, Tanya M.
Kidder, Molly S.
Bhattacharyya, Neil
Xing, Wei
Shen, Shiliang
Milne, Ginger L.
Castells, Mariana C.
Chhay, Heng
Boyce, Joshua A.
Publication Title: 
The Journal of Nutritional Biochemistry

Retinoids are essential in the proper establishment and maintenance of immunity. Although retinoids are implicated in immune related processes, their role in immune cell adhesion has not been well established. In this study, the effect of 9-cis-retinoic acid (9-cis-RA) on human hematopoietic cell adhesion was investigated. 9-cis-RA treatment specifically induced cell adhesion of the human immune cell lines HuT-78, NB4, RPMI 8866 and U937. Due to the prominent role of integrin receptors in mediating immune cell adhesion, we sought to evaluate if cell adhesion was integrin-dependent.

Author(s): 
Whelan, Jarrett T.
Chen, Jianming
Miller, Jabin
Morrow, Rebekah L.
Lingo, Joshuah D.
Merrell, Kaitlin
Shaikh, Saame Raza
Bridges, Lance C.
Publication Title: 
American Journal of Respiratory Cell and Molecular Biology

In this study, a genetically diverse panel of 43 mouse strains was exposed to phosgene and genome-wide association mapping performed using a high-density single nucleotide polymorphism (SNP) assembly. Transcriptomic analysis was also used to improve the genetic resolution in the identification of genetic determinants of phosgene-induced acute lung injury (ALI). We prioritized the identified genes based on whether the encoded protein was previously associated with lung injury or contained a nonsynonymous SNP within a functional domain.

Author(s): 
Leikauf, George D.
Concel, Vincent J.
Bein, Kiflai
Liu, Pengyuan
Berndt, Annerose
Martin, Timothy M.
Ganguly, Koustav
Jang, An Soo
Brant, Kelly A.
Dopico, Richard A.
Upadhyay, Swapna
Cario, Clinton
Di, Y. P. Peter
Vuga, Louis J.
Kostem, Emrah
Eskin, Eleazar
You, Ming
Kaminski, Naftali
Prows, Daniel R.
Knoell, Daren L.
Fabisiak, James P.
Publication Title: 
Clinical Calcium

Bone, as well as liver and lungs, is one of the most preferential metastatic targets for solid cancers including breast, prostate, and lung cancers. Control of the bone metastasis is clinically important ; because they are frequently associated with bone pain and pathological fracture which greatly diminish the quality of life for patients. Interaction between cancer cells and microenvironment of metastatic site play an important role for establishment of cancer metastasis.

Author(s): 
Hayashi, Shinichi
Hanamura, Toru
Publication Title: 
Journal of Biomechanics

Mast cells are known to respond to a number of stimuli, such as IgE antibody-antigen complexes, pathogens, chemical compounds, and physical stimulation, resulting in the activation of these cells and subsequent release of cytokines, inflammatory mediators and granules which can influence the pathophysiology of neighboring cells. Although different forms of physical stimulation (i.e. shear stress and acupuncture) have been investigated, the effect of cyclic tensile loading on mast cell activation has not.

Author(s): 
Fowlkes, Vennece
Wilson, Christopher G.
Carver, Wayne
Goldsmith, Edie C.
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