Interleukin-1 Receptor-Associated Kinases

Publication Title: 
The Journal of Clinical Endocrinology and Metabolism

CONTEXT: Type 1 diabetes (T1DM) is associated with increased cardiovascular mortality. It is a pro-inflammatory state as evidenced by increased circulating biomarkers and monocyte activity. The toll-like receptors (TLRs) are pattern recognition receptors, expressed abundantly on monocytes. TLR2 and TLR4 are important in atherosclerosis. However, there is a paucity of data examining TLR2 and TLR4 expression in T1DM and examining its contribution to the proinflammatory state.

Author(s): 
Devaraj, Sridevi
Dasu, Mohan R.
Rockwood, Jason
Winter, William
Griffen, Steven C.
Jialal, Ishwarlal
Publication Title: 
Diabetes Care

OBJECTIVE: Individuals with type 2 diabetes have a myriad of metabolic aberrations including increased inflammation, increasing their cardiovascular risk. Toll-like receptors (TLRs) and their ligands play a key role in insulin resistance and atherosclerosis. However, there is a paucity of data examining the expression and activity of TLRs in type 2 diabetes. Thus, in the present study, we examined TLR2 and TLR4 mRNA and protein expression, their ligands, and signaling in monocytes of recently diagnosed type 2 diabetic patients.

Author(s): 
Dasu, Mohan R.
Devaraj, Sridevi
Park, Samuel
Jialal, Ishwarlal
Publication Title: 
Arthritis Research & Therapy

INTRODUCTION: Epigallocatechin-3-gallate (EGCG) is a bioactive polyphenol of green tea and exerts potent anti-inflammatory effects by inhibiting signaling events and gene expression. Interleukin-1beta (IL-1β) is the principal cytokine linked to cartilage degradation in osteoarthritis (OA). The objective of this study was to evaluate the global effect of EGCG on IL-1β-induced expression of proteins associated with OA pathogenesis in human chondrocytes. METHODS: Primary OA chondrocytes were pretreated with EGCG (10 to 100 uM) and then stimulated with IL-1β (5 ng/ml) for 24 hours.

Author(s): 
Akhtar, Nahid
Haqqi, Tariq M.
Publication Title: 
PLoS pathogens

Bacterial infections following rhinovirus (RV), a common cold virus, are well documented, but pathogenic mechanisms are poorly understood. We developed animal and cell culture models to examine the effects of RV on subsequent infection with non-typeable Hemophilus influenzae (NTHi). We focused on NTHI-induced neutrophil chemoattractants expression that is essential for bacterial clearance. Mice infected with RV1B were superinfected with NTHi and lung bacterial density, chemokines and neutrophil counts determined.

Author(s): 
Unger, Benjamin L.
Faris, Andrea N.
Ganesan, Shyamala
Comstock, Adam T.
Hershenson, Marc B.
Sajjan, Umadevi S.
Publication Title: 
Rheumatology (Oxford, England)

OBJECTIVE: In OA, there is enhanced expression of pro-inflammatory cytokines such as IL-1β in the affected joint. Delphinidin, an anthocyanidin found in pigmented fruits and vegetables, has been shown to possess anti-inflammatory and antioxidant properties. In the present study we determined whether delphinidin would inhibit the IL-1β-induced activation of NF-κB in human chondrocytes and determined the mechanism of its action. METHODS: PGE2 levels and activation of NF-κB p65 in human OA chondrocytes were determined by ELISA-based assays.

Author(s): 
Haseeb, Abdul
Chen, Dongxing
Haqqi, Tariq M.
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