Interleukins

Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Only a small number of articles have investigated the relationship between mindfulness-based interventions (MBIs) and biomarkers. The aim of this systematic review was to study the effect of MBIs on specific biomarkers (cytokines, neuropeptides and C-reactive protein (CRP)) in both healthy subjects and cancer patients. METHODS: A search was conducted using PubMed, EMBASE, PsycINFO and the Cochrane library between 1980 and September 2016. RESULTS: A total of 13 studies with 1110 participants were included.

Author(s): 
Sanada, Kenji
Alda Díez, Marta
Salas Valero, Montserrat
Pérez-Yus, María C.
Demarzo, Marcelo M. P.
Montero-Marin, Jesús
García-Toro, Mauro
García-Campayo, Javier
Publication Title: 
Forschende Komplementarmedizin (2006)

BACKGROUND: To evaluate the evidence available on the effects of acupuncture point (acupoint) application for asthma therapy in adults. METHODS: Six electronic databases were searched up to May 2014 to identify relevant studies. Randomized controlled trials, which assessed the effects of acupoint application for asthma treatment in adults, were included in our review. The methodological quality of eligible studies was assessed by the Cochrane Collaboration's tool. The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated.

Author(s): 
Su, Li
Meng, Ling
Chen, Ran
Wu, Weihua
Peng, Bo
Man, Lixin
Publication Title: 
International Journal of Molecular Medicine

To evaluate whether an aqueous seed extract of Terminalia chebula Retzius inhibited development of atopy in vivo, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic symptoms to investigate the effects of the extract. We measured CD4+ cell numbers by hematoxylin and eosin (H&E) staining, and determined the expression levels of matrix metalloproteinase (MMP)-9, interleukin (IL)-31, and T-bet genes, in this animal model.

Author(s): 
Nam, Dong-Yoon
Lee, Jin-Man
Heo, Jin-Chul
Lee, Sang-Han
Publication Title: 
British Journal of Haematology

Blood transfusion therapy is life-saving for patients with beta-thalassaemia and sickle cell disease (SCD), but often results in severe iron overload. This pilot study examined whether the biomarkers of tissue injury or inflammation differ in these two diseases. Plasma malondialdehyde (MDA) was significantly increased 1.8-fold in thalassaemia relative to control patients. In contrast, MDA in SCD was not significantly different from controls. In multivariate analysis, the strongest predictors of elevated MDA were liver iron concentration (P < 0.001) and specific diagnosis (P = 0.019).

Author(s): 
Walter, Patrick B.
Fung, Ellen B.
Killilea, David W.
Jiang, Qing
Hudes, Mark
Madden, Jacqueline
Porter, John
Evans, Patricia
Vichinsky, Elliott
Harmatz, Paul
Publication Title: 
The Journal of the American Osteopathic Association

CONTEXT: Clinical studies have supported the efficacy of a variety of osteopathic manipulative techniques. However, an evidence base for the cellular mechanisms underlying these clinical findings is lacking. OBJECTIVE: To investigate human fibroblast proliferation and interleukin secretory profiles in response to modeled repetitive motion strain (RMS) and modeled indirect osteopathic manipulative techniques (IOMT). The authors hypothesized that the RMS model would increase fibroblast proliferation and proinflammatory interleukin secretion, while the IOMT model would reverse these effects.

Author(s): 
Meltzer, Kate R.
Standley, Paul R.
Publication Title: 
The Journal of Biological Chemistry

Inflammation underlying immune pathology and tissue damage involves an intricate interplay between multiple immunological and biochemical mediators. Cytokines represent the key immune mediators that trigger a cascade of reactions that drive processes such as angiogenesis and proteolytic damage to tissues. IL-17 has now been shown to be a pivotal cytokine in many autoimmune diseases, supplanting the traditional Th1-Th2 paradigm. Also, the dual role of proinflammatory IFN-γ has unraveled new complexities in the cytokine biology of such disorders.

Author(s): 
Rajaiah, Rajesh
Puttabyatappa, Muraly
Polumuri, Swamy K.
Moudgil, Kamal D.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

There is increasing evidence that age-associated chronic low-grade inflammation promotes the development of both large-vessel disease (myocardial infarction, stroke, peripheral arterial disease) and small-vessel pathologies (including vascular cognitive impairment) in older persons. However, the source of age-related chronic vascular inflammation remains unclear.

Author(s): 
Csiszar, Anna
Sosnowska, Danuta
Wang, Mingyi
Lakatta, Edward G.
Sonntag, William E.
Ungvari, Zoltan
Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

A chronic inflammatory disorder of the respiratory airways, asthma is characterized by bronchial airway inflammation resulting in increased mucus production and airway hyper-responsiveness. The resultant symptomatology includes episodes of wheezing, coughing, and shortness of breath. Asthma is a multifactorial disease process with genetic, allergic, environmental, infectious, emotional, and nutritional components. The underlying pathophysiology of asthma is airway inflammation.

Author(s): 
Miller, A. L.
Publication Title: 
Oxidative Medicine and Cellular Longevity

Summer savory (Satureja hortensis L., Lamiaceae) is used in several regions of the world as a spice and folk medicine. Anti-inflammatory and cytoprotective effects of S. hortensis and of its rosmarinic acid-rich phenolic fraction have been demonstrated in animal trials. However, previous studies of rosmarinic acid in cell models have yielded controversial results. In this study, we investigated the effects of summer savory extracts on H2O2-challenged human lymphoblastoid Jurkat T cells.

Author(s): 
Chkhikvishvili, Irakli
Sanikidze, Tamar
Gogia, Nunu
Mchedlishvili, Tamar
Enukidze, Maia
Machavariani, Marine
Vinokur, Yakov
Rodov, Victor
Publication Title: 
Clinical and vaccine immunology: CVI

β-Glucans are well known for their immunomodulatory capacities in humans and mice. For this reason, together with the European ban on growth-promoting antibiotics, β-glucans are intensively used in pig feed. However, as shown in the present study, there is much variation in the stimulatory capacities of β-glucans from different sources.

Author(s): 
Sonck, Eva
Devriendt, Bert
Goddeeris, Bruno
Cox, Eric

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