Intervertebral Disc

Publication Title: 
Spine

STUDY DESIGN: Nonviral transfection of nucleus pulposus cells with a telomerase expression construct to assess the effects on cellular lifespan, function, karyotypic stability, and transformation properties. OBJECTIVES: To investigate whether telomerase gene therapy can extend the cellular lifespan while retaining functionality of nucleus pulposus cells in a safe manner. SUMMARY OF BACKGROUND DATA: Degeneration of the intervertebral disc is an age-related condition in which cells responsible for the maintenance and health of the disc deteriorate with age.

Author(s): 
Chung, Sylvia A.
Wei, Ai Qun
Connor, David E.
Webb, Graham C.
Molloy, Timothy
Pajic, Marina
Diwan, Ashish D.
Publication Title: 
The Spine Journal: Official Journal of the North American Spine Society

BACKGROUND CONTEXT: The intervertebral disc is a common source of low back pain (LBP). Prospective studies suggest that treatments that intermittently distract the disc might be beneficial for chronic LBP. Although the potential exists for distraction therapies to affect the disc biomechanically, their effect on intradiscal stress is debated.

Author(s): 
Gay, Ralph E.
Ilharreborde, Brice
Zhao, Kristin D.
Berglund, Lawrence J.
Bronfort, Gert
An, Kai-Nan
Publication Title: 
Journal of Biomechanics

Fresh frozen spine specimens are commonly used in biomechanical investigations of the spine. Since many study designs require staged preparation and testing, the effect of multiple freeze-thaw cycles on motion behavior should be understood. The objective of this study was to investigate the effect of multiple freeze-thaw cycles on the biomechanical parameters measured during dynamic pure moment loading. Ten porcine lumbar motion segments were harvested immediately after death and potted in acrylic fixtures.

Author(s): 
Hongo, Michio
Gay, Ralph E.
Hsu, Jui-Ting
Zhao, Kristin D.
Ilharreborde, Brice
Berglund, Lawrence J.
An, Kai-Nan
Publication Title: 
Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society

As clinical evidence suggests that mechanical forces can have both reparative and traumatic effects on the spine, we investigated responses to different magnitudes, frequencies, and durations of applied tensile strain in an in vitro system. We examined the interactions of inflammatory and mechanical stimuli on cells isolated from the annulus fibrosus. Rabbit annulus fibrosus fibrochondrocytes were cultured in the presence or absence of an inflammatory stimulus.

Author(s): 
Sowa, Gwendolyn
Coelho, Paulo
Vo, Nam
Bedison, Ron
Chiao, Andrew
Davies, Cara
Studer, Rebecca
Kang, James
Publication Title: 
Spine

STUDY DESIGN: Comparison of sodium concentration ([Na]) and proton T2 relaxation time between normal and degenerated discs in a rabbit model. OBJECTIVE: The purpose of this article was to evaluate quantitative [Na] and T2 characteristics of discs associated with degenerative changes. SUMMARY OF BACKGROUND DATA: Intervertebral disc degeneration is a common chronic condition that may lead to back pain, limited activity, and disability.

Author(s): 
Moon, Chan Hong
Jacobs, Lloydine
Kim, Jung-Hwan
Sowa, Gwendolyn
Vo, Nam
Kang, James
Bae, Kyongtae Ty
Publication Title: 
Spine

STUDY DESIGN: Development of a dual-tuned proton/sodium radiofrequency (RF) coil for magnetic resonance imaging (MRI) of the rabbit spine and quantification of sodium concentration in intervertebral discs. OBJECTIVE: To develop the dual-tuned proton/sodium MRI of rabbit lumbar spine to investigate proteoglycan matrix content and intervertebral disc degeneration (IDD). SUMMARY OF BACKGROUND DATA: IDD is a common chronic condition that may lead to back pain, limited activity, and disability. Early-stage IDD involves the loss of proteoglycan matrix and water content in the disc.

Author(s): 
Moon, Chan Hong
Kim, Jung-Hwan
Jacobs, Lloydine
Zhao, Tiejun
Sowa, Gwendolyn
Vo, Nam
Kang, James
Bae, Kyongtae Ty
Publication Title: 
European Spine Journal: Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

The objective of the current study was to find out whether yoga practice was beneficial to the spine by comparing degenerative disc disease in the spines of long-time yoga practitioners and non-yoga practicing controls, using an objective measurement tool, magnetic resonance imaging. This matched case-control study comprised 18 yoga instructors with teaching experience of more than 10 years and 18 non-yoga practicing asymptomatic individuals randomly selected from a health checkup database.

Author(s): 
Jeng, Chin-Ming
Cheng, Tzu-Chieh
Kung, Ching-Huei
Hsu, Hue-Chen
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

The use of static-postural and dynamic-bending roentgenography by the medical and chiropractic professions was reviewed and a retrospective study of 30 symptomatic subjects was conducted to compare the diagnostic discrimination of dynamic lateral bending (DLB) procedures to that of a previously-reported static-postural method (Farfan) in determining the lumbar spine level which is most predisposed to the eventual development of degenerative disc disease.

Author(s): 
Vernon, H.
Publication Title: 
Spine

Ninety-nine anteroposterior and lateral lumbar radiographs taken of men, 18 to 55 years of age, were randomly selected from participants in a population survey of low-back pain. Thirty-one (31%) had never had low-back pain; 44 (44%) had or were having mild low-back pain; and 24 (24%) had or were having severe low-back pain. Three chiropractors assessed 56 radiographic variables, which included determinations of disc space height, vertebral malalignments and subluxations, spondylosis, postural disturbances, relationships among pelvis and spine and other congenital or acquired abnormalities.

Author(s): 
Frymoyer, J. W.
Phillips, R. B.
Newberg, A. H.
MacPherson, B. V.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

The cause of restricted intervertebral mobility, or joint fixation, has generated much speculation. A number of etiologies have been proposed in the literature by authors addressing this question. The four possible theories that merit further investigation include meniscoid entrapment, displaced intervertebral disc fragments, segmental or intersegmental muscle spasm and periarticular connective tissue adhesions.

Author(s): 
Rahlmann, J. F.

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