Publication Title: 
The Journal of Nutrition

Mexico's Oportunidades program provides conditional cash transfers, nutrition education, health services, and fortified food supplements for the young children of poor families. We have documented the effects of the program on growth and reduction of anemia. To better understand the impact pathways and disentangle the relative effects on dietary intake of the food supplements compared with other program components, we analyzed data from a randomized effectiveness evaluation of the Oportunidades program in rural children aged 12-59 mo.

Ramírez-Silva, Ivonne
Rivera, Juan A.
Leroy, Jef L.
Neufeld, Lynnette M.
Publication Title: 
The Journal of Nutrition

The NHANES 2003-2006 has assessed iron and iodine status, 2 trace element nutrients of continued public health interest, in the U.S. population. We investigated associations of sociodemographic (age, sex, race-ethnicity, education, income) and lifestyle (smoking, alcohol consumption, BMI, physical activity, dietary supplement use) variables with the iron status indicators serum ferritin, soluble transferrin receptor (sTfR), and body iron in women aged 20-49 y (n = 2539, 2513, and 2509, respectively) and with urine iodine, a biomarker of iodine intake, in adults aged ≥ 20 y (n = 3066).

Pfeiffer, Christine M.
Sternberg, Maya R.
Caldwell, Kathleen L.
Pan, Yi
Publication Title: 
Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række

BACKGROUND: A low supply of iron in the diet may result in iron deficiency and mild iron-deficiency anaemia in healthy individuals. Women are more susceptible than men because of menstrual iron loss. We compared the effect of a low dose of iron, administered as a dietary supplement, with a high pharmacological dose of iron to otherwise healthy individuals with iron deficiency and mild iron deficiency anaemia.

Ulvik, Rune J.
Møller, Rolf
Hervig, Tor
Publication Title: 
The Journal of Nutrition

Hepcidin, the pivotal regulator of iron metabolism, plays a critical role in multiple diseases including anemia of chronic disease and hemochromatosis. Recent studies have focused on identifying antagonists of hepcidin. We hypothesized that bioactive extracts from Chinese medicinal plants may be efficacious in the inhibition of expression of the hepcidin-encoding gene (HAMP) product, hepcidin.

Guan, Yu
An, Peng
Zhang, Zhuzhen
Zhang, Fan
Yu, Yu
Wu, Qian
Shi, Yanbo
Guo, Xin
Tao, Yunlong
Wang, Fudi
Publication Title: 
PloS One

BACKGROUND: Iron deficiency anemia remains a major global health problem. Higher iron demands provide the potential for a targeted preventative approach before anemia develops. The primary study objective was to develop and validate a metric that stratifies recommended dietary iron intake to compensate for patient-specific non-menstrual hemorrhagic losses. The secondary objective was to examine whether iron deficiency can be attributed to under-replacement of epistaxis (nosebleed) hemorrhagic iron losses in hereditary hemorrhagic telangiectasia (HHT).

Finnamore, Helen
Le Couteur, James
Hickson, Mary
Busbridge, Mark
Whelan, Kevin
Shovlin, Claire L.
Publication Title: 
Antimicrobial Agents and Chemotherapy

Oral iron therapy can increase the abundance of bacterial pathogens, e.g., Salmonella spp., in the large intestine of African children. Carvacrol is a natural compound with antimicrobial activity against various intestinal bacterial pathogens, among which is the highly prevalent Salmonella enterica serovar Typhimurium. This study aimed to explore a presumed interaction between carvacrol and bacterial iron handling and to assess the potential of carvacrol in preventing the increase of bacterial pathogenicity during high iron availability. S.

Kortman, Guus A. M.
Roelofs, Rian W. H. M.
Swinkels, Dorine W.
de Jonge, Marien I.
Burt, Sara A.
Tjalsma, Harold
Publication Title: 
PloS One

BACKGROUND: Iron deficiency is common during pregnancy. Experimental animal studies suggest that it increases cardiovascular risk in the offspring.

Alwan, Nisreen A.
Cade, Janet E.
Greenwood, Darren C.
Deanfield, John
Lawlor, Debbie A.
Publication Title: 
The American Journal of Clinical Nutrition

Iron-deficiency anemia impaired the blastogenic response of splenic lymphocytes and partially purified T cells to Concanavalin A and phytohemagglutinin. The response of splenic lymphocytes and partially B cells to bacterial lipopolysaccharide was also significantly impaired. Caloric restriction in pair-fed mice did not have any significant effect. Blastogenic response to the three mitogens was restored to normal after anemic mice were fed the regular diet containing 25 to 30 mg Fe/kg (FeSO4) for approximately 10 days.

Kuvibidila, S.
Nauss, K. M.
Baliga, B. S.
Suskind, R. M.
Publication Title: 
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience

Caloric restriction (CR) reduces the pathological effects of aging and extends the lifespan in many species, including nonhuman primates, although the effect on the brain is less well characterized. We used two common indicators of aging, motor performance speed and brain iron deposition measured in vivo using magnetic resonance imaging, to determine the potential effect of CR on elderly rhesus macaques eating restricted (n=24, 13 males, 11 females) and standard (n=17, 8 males, 9 females) diets.

Kastman, Erik K.
Willette, Auriel A.
Coe, Christopher L.
Bendlin, Barbara B.
Kosmatka, Kris J.
McLaren, Donald G.
Xu, Guofan
Canu, Elisa
Field, Aaron S.
Alexander, Andrew L.
Voytko, Mary Lou
Beasley, T. Mark
Colman, Ricki J.
Weindruch, Richard H.
Johnson, Sterling C.
Publication Title: 
Asia Pacific Journal of Clinical Nutrition

A mathematical model for determining the Yin Yang nature of fruits was established in our previous study. The objective of this study was to validate the mathematical model using animal experiments. One hundred and twenty Wistar II female rats were randomly divided into five diet groups: A, B, C, D and E that were administered with saline solution, hot Traditional Chinese Medicine (TCM) tonic, cold TCM tonic, hot (Yang) formulated mineral solution and cold (Yin) formulated mineral solution, respectively.

Ni, Li
Lin, Xiao
Rao, Pingfan


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