Irritants

Publication Title: 
Arzneimittel-Forschung

The general pharmacological profile of 7-fluoro-1-methyl-3-(methylsulfonyl)- 4(1H)-quinolone BTS 53 554, CAS 76568-68-8), the main metabolite of a new vasodilator, flosequinan (BTS 49 465), was investigated. 1. The central nervous system: BTS 53 554 at the dose of 30 mg/kg i.v. caused an increase in respiratory rate and a sedation in general behavior in rats. The drug also inhibited acetic acid-induced writhing and slightly decreased normal body temperature in mice. However, the drug at the doses up to 30 mg/kg i.v.

Author(s): 
Fujita, S.
Ikezono, K.
Umezato, M.
Hosoki, E.
Toba, Y.
Ishikawa, M.
Kusunoki, A.
Shintani, S.
Publication Title: 
Arzneimittel-Forschung

Pharmacological effects of a new vasodilator, flosequinan (7-fluoro-1-methyl-3-(methylsulfinyl)-4(1H)-quinolone, BTS 49 465, CAS 76568-02-0) on the central nervous system, somatic nervous system, autonomic nervous system and smooth muscle, digestive system and miscellaneous organs were investigated. 1. The central nervous system: Flosequinan inhibited acetic acid-induced writhing at doses of more than 30 mg/kg p.o. and decreased body temperature and tended to decrease spontaneous movement slightly in mice at a dose of 100 mg/kg p.o.

Author(s): 
Ikezono, K.
Fujita, S.
Umezato, M.
Hosoki, E.
Toba, Y.
Kusunoki, A.
Shintani, S.
Publication Title: 
Journal of the Royal Society of Health
Author(s): 
Packham, C. L.
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

INTRODUCTION: The aim of the study was to investigate the hypoalgesic effects of a single spinal manipulation treatment on acute inflammatory reactions and pain induced by cutaneous application of capsaicin. METHODS: Twenty healthy subjects participated in the experiment, which consisted of 2 sessions. In both sessions, following control measurements, topical capsaicin was applied to the right or left forearm to induce cutaneous inflammatory reactions. The cream was removed after 20 minutes.

Author(s): 
Mohammadian, Parvaneh
Gonsalves, Antonio
Tsai, Chris
Hummel, Thomas
Carpenter, Thomas
Publication Title: 
Journal of Manipulative and Physiological Therapeutics

INTRODUCTION: The aim of the study was to investigate the hypoalgesic effects of a single spinal manipulation treatment on acute inflammatory reactions and pain induced by cutaneous application of capsaicin. METHODS: Twenty healthy subjects participated in the experiment, which consisted of 2 sessions. In both sessions, following control measurements, topical capsaicin was applied to the right or left forearm to induce cutaneous inflammatory reactions. The cream was removed after 20 minutes.

Author(s): 
Mohammadian, Parvaneh
Gonsalves, Antonio
Tsai, Chris
Hummel, Thomas
Carpenter, Thomas
Subscribe to RSS - Irritants