Isomerases

Publication Title: 
The Journal of Biological Chemistry
Author(s): 
Davidson, B. E.
Blackburn, E. H.
Dopheide, T. A.
Publication Title: 
The Biochemical Journal

1. The activities of protein disulphide-isomerase (PDI) and thioredoxin in catalysing disulphide bond isomerization in a protein substrate were compared by using the standard assay, namely the re-activation of 'scrambled' RNAase. 2. The specific activity of PDI was 25-fold greater than that of thioredoxin. 3. The greater efficiency of PDI compared with thioredoxin is considered to be due more to the presence of multiple catalytic domains in PDI than to differences in their active-site sequences. 4.

Author(s): 
Hawkins, H. C.
Blackburn, E. C.
Freedman, R. B.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Prostaglandins (PGs) are a family of cellular messengers exerting diverse homeostatic and pathophysiologic effects. Recently, several studies reported significant increases of PGI(2) and PGF(2α) after the inhibition of microsomal PGE synthase-1 (mPGES-1) expression, which indicated that PGH(2) metabolism might be redistributed when the PGE(2) pathway is blocked.

Author(s): 
Yu, Rui
Xiao, Lei
Zhao, Guiqing
Christman, John W.
van Breemen, Richard B.
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