Isotope Labeling

Publication Title: 
Advances in Nutrition (Bethesda, Md.)

Epidemiological studies suggest an inverse relationship between tomato consumption and serum and tissue lycopene (LYC) levels with risk of some chronic diseases, including several cancers and cardiovascular disease. LYC, the red carotenoid found in tomatoes, is often considered to be the primary bioactive carotenoid in tomatoes that mediates health benefits, but other colorless precursor carotenoids, phytoene (PE) and phytofluene (PF), are also present in substantial quantities. PE and PF are readily absorbed from tomato foods and tomato extracts by humans.

Engelmann, Nancy J.
Clinton, Steven K.
Erdman, John W.
Publication Title: 
Food Chemistry

While putative disease-preventing lycopene metabolites are found in both tomato (Solanum lycopersicum) products and in their consumers, mammalian lycopene metabolism is poorly understood. Advances in tomato cell culturing techniques offer an economical tool for generation of highly-enriched (13)C-lycopene for human bioavailability and metabolism studies.

Moran, Nancy Engelmann
Rogers, Randy B.
Lu, Chi-Hua
Conlon, Lauren E.
Lila, Mary Ann
Clinton, Steven K.
Erdman, John W.
Publication Title: 
Journal of Lipid Research

Western diets are enriched in omega-6 vs. omega-3 fatty acids, and a shift in this balance toward omega-3 fatty acids may have health benefits. There is limited information about the catabolism of 3-series prostaglandins (PG) formed from eicosapentaenoic acid (EPA), a fish oil omega-3 fatty acid that becomes elevated in tissues following fish oil consumption. Quantification of appropriate urinary 3-series PG metabolites could be used for noninvasive measurement of omega-3 fatty acid tone.

Kuklev, Dmitry V.
Hankin, Joseph A.
Uhlson, Charis L.
Hong, Yu H.
Murphy, Robert C.
Smith, William L.
Publication Title: 
Journal of Zhejiang University. Science. B

Psidium guajava (guava) leaf is a phytotherapic used in folk medicine to treat gastrointestinal and respiratory disturbances and is used as anti-inflammatory medicine. In nuclear medicine, blood constituents (BC) are labelled with technetium-99m ((99m)Tc) and used to image procedures. However, data have demonstrated that synthetic or natural drugs could modify the labelling of BC with (99m)Tc. The aim of this work was to evaluate the effects of aqueous extract of guava leaves on the labelling of BC with (99m)Tc.

Abreu, P. R. C.
Almeida, M. C.
Bernardo, R. M.
Bernardo, L. C.
Brito, L. C.
Garcia, E. a. C.
Fonseca, A. S.
Bernardo-Filho, M.
Publication Title: 
The American Journal of Chinese Medicine

We observed the acute effects of Qigong training on the levels of human endogenous opioid peptides, such as beta-endorphin, and other stress hormones [adrenocorticotrophic hormone (ACTH), cortisol, and dehydroepiandrosterone-sulfate (DHEA-S)] in a group of ChunDoSunBup Qigong trainees. At pre (-10 min), mid (40 min) and post (70 min) time of training, blood was taken for the determination of plasma level of hormones. The level of beta-endorphin was significantly increased during the mid-time of training while the level of ACTH declined at the mid- and post-time of training.

Ryu, H.
Lee, H. S.
Shin, Y. S.
Chung, S. M.
Lee, M. S.
Kim, H. M.
Chung, H. T.


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