Isoxazoles

Publication Title: 
Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology

GABA(A) receptors mediate both fast phasic inhibitory postsynaptic potentials and slower tonic extrasynaptic inhibition. Hyperpolarizing phasic GABAergic inhibition requires the activity of neuron-specific chloride-extruding potassium-chloride cotransporter KCC2 in adult CNS. However, the possible role of KCC2 in tonic GABAergic inhibition and the associated behaviors is unknown.

Author(s): 
Tornberg, Janne
Segerstråle, Mikael
Kulesskaya, Natalia
Voikar, Vootele
Taira, Tomi
Airaksinen, Matti S.
Publication Title: 
Molecular Endocrinology (Baltimore, Md.)

Ayurveda, the ancient Indian system of health care and medicine, has a well-organized materia medica in which plants form a dominant part. A key illustration of the exploitation of this knowledge toward the development of a modern drug is the isolation and characterization of two antihyperlipidemic compounds, Z-, and E-guggulsterone from the tree Commiphora mukul, the exudate of which has been traditionally used for mitigating lipid disorders.

Author(s): 
Wu, Jun
Xia, Chunsheng
Meier, Jannika
Li, Suzhen
Hu, Xiao
Lala, Deepak S.
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