Italy

Publication Title: 
Trends in Pharmacological Sciences

Acetylation of chromatin-interacting proteins is central to the epigenetic regulation of genome architecture and gene expression. Chemicals that modulate the acetylation of nuclear proteins have proved instrumental in experimental models of several human diseases. Sirtuins represent a new class of evolutionary conserved histone deacetylases, originally identified in yeast, that have emerging pathogenetic roles in cancer, diabetes, muscle differentiation, heart failure, neurodegeneration and aging.

Author(s): 
Porcu, Marco
Chiarugi, Alberto
Publication Title: 
Experimental Gerontology

The brown fat specific UnCoupling Protein 1 (UCP1) is involved in thermogenesis, a process by which energy is dissipated as heat in response to cold stress and excess of caloric intake. Thermogenesis has potential implications for body mass control and cellular fat metabolism. In fact, in humans, the variability of the UCP1 gene is associated with obesity, fat gain and metabolism. Since regulation of metabolism is one of the key-pathways in lifespan extension, we tested the possible effects of UCP1 variability on survival.

Author(s): 
Rose, Giuseppina
Crocco, Paolina
D'Aquila, Patrizia
Montesanto, Alberto
Bellizzi, Dina
Passarino, Giuseppe
Publication Title: 
Recenti Progressi in Medicina

The 20th century will be remembered for its technological and scientific discoveries and for the exceptional changes in the demographic structure brought about by these and the improved economic and social conditions; in fact, the reduction in the birth rate and a fall in the death rate have caused an increase in the population of the elderly.

Author(s): 
Cicconetti, Paolo
Riolo, Noemi
Ettorre, Evaristo
Costarella, Marianna
Priami, Carolina
Marigliano, Vincenzo
Publication Title: 
Experimental Gerontology

High prevalence and low female/male ratio for validated centenarians are observed in Sardinia and these findings appear to be thus far unique to this island. Moreover a specific region on the island is characterized by exceptional male longevity. We calculated the extreme longevity index (ELI), defined as the percentage of persons born in Sardinia between 1880 and 1900, who became centenarians.

Author(s): 
Poulain, Michel
Pes, Giovanni Mario
Grasland, Claude
Carru, Ciriaco
Ferrucci, Luigi
Baggio, Giovannella
Franceschi, Claudio
Deiana, Luca
Publication Title: 
Molecular Biology Reports

The PTPN22 gene, located on chromosome 1p13, encoding lymphoid protein tyrosine phosphatase (LYP), plays a crucial role in the negative control of T lymphocyte activation. Since the age-related change in T-cell signal transduction may be one of the most important causes of cell-mediated immune response decline with ageing, we performed a population-based association study to test whether the PTPN22 1858C>T (R620W) functional polymorphism affects the ability to survive to old age and to reach even exceptional life expectancy.

Author(s): 
Napolioni, Valerio
Natali, Annalia
Saccucci, Patrizia
Lucarini, Nazzareno
Publication Title: 
Rejuvenation Research

Long-living individuals (LLIs) are used to study exceptional longevity. A number of genetic variants have been found associated in LLIs to date, but further identification of variants would improve knowledge on the mechanisms regulating the rate of aging. Therefore, we performed a genome-wide association study on 410 LLIs and 553 young control individuals with a 317K single-nucleotide polymorphism (SNP) chip to identify novel traits associated with aging.

Author(s): 
Malovini, Alberto
Illario, Maddalena
Iaccarino, Guido
Villa, Francesco
Ferrario, Anna
Roncarati, Roberta
Anselmi, Chiara Viviani
Novelli, Valeria
Cipolletta, Ersilia
Leggiero, Eleonora
Orro, Alessandro
Rusciano, Maria Rosaria
Milanesi, Luciano
Maione, Angela Serena
Condorelli, Gianluigi
Bellazzi, Riccardo
Puca, Annibale A.
Publication Title: 
Age (Dordrecht, Netherlands)

Longevity phenotype in humans results from the influence of environmental and genetic factors. Few gene polymorphisms have been identified so far with a modest effect on lifespan leaving room for the search of other players in the longevity game. It has been recently demonstrated that targeted disruption of the mouse homolog of the human angiotensin II type 1 receptor (AT1R) gene (AGTR1) translates into marked prolongation of animal lifespan (Benigni et al., J Clin Invest 119(3):524-530, 2009).

Author(s): 
Benigni, Ariela
Orisio, Silvia
Noris, Marina
Iatropoulos, Paraskevas
Castaldi, Davide
Kamide, Kei
Rakugi, Hiromi
Arai, Yasumichi
Todeschini, Marta
Ogliari, Giulia
Imai, Enyu
Gondo, Yasuyuki
Hirose, Nobuyoshi
Mari, Daniela
Remuzzi, Giuseppe
Publication Title: 
PloS One

The aging phenotype in humans has been thoroughly studied but a detailed metabolic profiling capable of shading light on the underpinning biological processes of longevity is still missing. Here using a combined metabonomics approach compromising holistic (1)H-NMR profiling and targeted MS approaches, we report for the first time the metabolic phenotype of longevity in a well characterized human aging cohort compromising mostly female centenarians, elderly, and young individuals.

Author(s): 
Collino, Sebastiano
Montoliu, Ivan
Martin, FranÁois-Pierre J.
Scherer, Max
Mari, Daniela
Salvioli, Stefano
Bucci, Laura
Ostan, Rita
Monti, Daniela
Biagi, Elena
Brigidi, Patrizia
Franceschi, Claudio
Rezzi, Serge
Publication Title: 
Age (Dordrecht, Netherlands)

Longevity phenotype in humans results from the influence of environmental and genetic factors. Few gene polymorphisms have been identified so far with a modest effect on lifespan leaving room for the search of other players in the longevity game. It has been recently demonstrated that targeted disruption of the mouse homolog of the human angiotensin II type 1 receptor (AT1R) gene (AGTR1) translates into marked prolongation of animal lifespan (Benigni et al., J Clin Invest 119(3):524-530, 2009).

Author(s): 
Benigni, Ariela
Orisio, Silvia
Noris, Marina
Iatropoulos, Paraskevas
Castaldi, Davide
Kamide, Kei
Rakugi, Hiromi
Arai, Yasumichi
Todeschini, Marta
Ogliari, Giulia
Imai, Enyu
Gondo, Yasuyuki
Hirose, Nobuyoshi
Mari, Daniela
Remuzzi, Giuseppe
Publication Title: 
Age (Dordrecht, Netherlands)

The pathways that regulate energy homeostasis, the mechanisms of damage repair, and the signaling response to internal environmental changes or external signals have been shown to be critical in modulating lifespan of model organisms and humans. In order to investigate whether genetic variation of genes involved in these pathways contribute to longevity, a two-stage case-control study in two independent sets of long-lived individuals from Calabria (Italy) was performed. In stage 1, 317 SNPs in 104 genes were analyzed in 78 cases (median age 98 years) and 71 controls (median age 67 years).

Author(s): 
Di Cianni, Fausta
Campa, Daniele
Tallaro, Federica
Rizzato, Cosmeri
de Rango, Francesco
Barale, Roberto
Passarino, Giuseppe
Canzian, Federico
Gemignani, Federica
Montesanto, Alberto
Landi, Stefano
Rose, Giuseppina

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