Janus Kinases

Publication Title: 
Hepatology (Baltimore, Md.)

Glycine N-methyltransferase (GNMT) is the main enzyme responsible for catabolism of excess hepatic S-adenosylmethionine (SAMe). GNMT is absent in hepatocellular carcinoma (HCC), messenger RNA (mRNA) levels are significantly lower in livers of patients at risk of developing HCC, and GNMT has been proposed to be a tumor-susceptibility gene for liver cancer. The identification of several children with liver disease as having mutations of the GNMT gene further suggests that this enzyme plays an important role in liver function.

Martínez-Chantar, M. Luz
Vázquez-Chantada, Mercedes
Ariz, Usue
Martínez, Núria
Varela, Marta
Luka, Zigmund
Capdevila, Antonieta
Rodríguez, Juan
Aransay, Ana M.
Matthiesen, Rune
Yang, Heping
Calvisi, Diego F.
Esteller, Manel
Fraga, Mario
Lu, Shelly C.
Wagner, Conrad
Mato, José M.
Publication Title: 
Molecular cancer research: MCR

Mesothelin (MSLN) is a cell surface glycoprotein that is overexpressed in human pancreatic cancer. Although its value as a tumor marker for diagnosis and prognosis and as a preferred target of immunointervention has been evaluated, there is little information on the growth advantage of MSLN on tumor cells.

Bharadwaj, Uddalak
Li, Min
Chen, Changyi
Yao, Qizhi
Publication Title: 
Journal of Lipid Research

PCSK9 degrades LDL receptor (LDLR) in liver and thereby influences the circulating level of LDL cholesterol. Hence, mechanisms inhibiting PCSK9 expression have potential for cholesterol-lowering intervention. Previously, we demonstrated that oncostatin M (OM) activates LDLR gene transcription, resulting in an increased LDL uptake in HepG2 cells and a reduction of plasma LDL in hypercholesterolemic hamsters. Here we identify the suppression of PCSK9 expression by OM as one new mechanism that increases LDLR protein in HepG2 cells.

Cao, Aiqin
Wu, Minhao
Li, Hai
Liu, Jingwen
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