Karyopherins

Publication Title: 
Journal of Leukocyte Biology

High mobility group box 1 (HMGB1) can be actively secreted by macrophages/monocytes in response to exogenous and endogenous inflammatory stimuli (such as bacterial endotoxin, TNF-alpha, IL-1, and IFN-gamma) or passively released by necrotic cells and mediates innate and adaptive inflammatory responses to infection and injury. Here, we demonstrated that a reactive oxygen species, hydrogen peroxide (H(2)O(2)), induces active and passive HMGB1 release from macrophage and monocyte cultures in a time- and dose-dependent manner.

Author(s): 
Tang, Daolin
Shi, Yongzhong
Kang, Rui
Li, Tong
Xiao, Weimin
Wang, Haichao
Xiao, Xianzhong
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

High-mobility-group box 1 (HMGB1), a nuclear protein, has recently been identified as an important mediator of local and systemic inflammatory diseases when released into the extracellular milieu. Anti-inflammatory regulation by the stress response is an effective autoprotective mechanism when the host encounters harmful stimuli, but the mechanism of action remains incompletely delineated.

Author(s): 
Tang, Daolin
Kang, Rui
Xiao, Weimin
Wang, Haichao
Calderwood, Stuart K.
Xiao, Xianzhong
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