Ki-67 Antigen

Publication Title: 
Journal of Cosmetic Dermatology

INTRODUCTION: Imedeenô is a cosmeceutical that provides nutrients to the skin. One of its active ingredients is the Marine Complexô (MC). AIM: The aim of this study was to evaluate whether MC affects skin morphogenesis differently in female and male human skin equivalents (HSEs). METHODS: Human skin equivalents were established with cells obtained from female or male donors between 30 and 45 years of age and cultured for seven or 11 weeks in the presence or absence of MC.

Author(s): 
Rietveld, Marion
Janson, David
Siamari, Rachida
Vicanova, Jana
Andersen, Maja Troest
El Ghalbzouri, Abdoelwaheb
Publication Title: 
PloS One

Pancreatic cancer (PaCa) is one of the most lethal cancers, with an estimated 5-year survival of <5% even when patients are given the best treatment available. In addition, these treatments are often toxic and expensive, thus new agents which are safe, affordable and effective are urgently needed. We describe here the results of our study with acetyl-11-keto-β-boswellic acid (AKBA), an agent obtained from an Ayurvedic medicine, gum resin of Boswellia serrata. Whether AKBA has an activity against human PaCa, was examined in in vitro models and in an orthotopic nude mouse model of PaCa.

Author(s): 
Park, Byoungduck
Prasad, Sahdeo
Yadav, Vivek
Sung, Bokyung
Aggarwal, Bharat B.
Publication Title: 
PloS One

Pancreatic cancer (PaCa) is one of the most lethal cancers, with an estimated 5-year survival of <5% even when patients are given the best treatment available. In addition, these treatments are often toxic and expensive, thus new agents which are safe, affordable and effective are urgently needed. We describe here the results of our study with acetyl-11-keto-β-boswellic acid (AKBA), an agent obtained from an Ayurvedic medicine, gum resin of Boswellia serrata. Whether AKBA has an activity against human PaCa, was examined in in vitro models and in an orthotopic nude mouse model of PaCa.

Author(s): 
Park, Byoungduck
Prasad, Sahdeo
Yadav, Vivek
Sung, Bokyung
Aggarwal, Bharat B.
Publication Title: 
Clinical Cancer Research: An Official Journal of the American Association for Cancer Research

Over-consumption of dietary fat has been suggested to promote the development and progression of prostate cancer in men. The present study was conducted to answer the following questions: (a) Can dietary fat reduction decrease tumor growth rates of Los Angeles prostate cancer (LAPC)-4 xenografts in severe combined immunodeficient (SCID) mice independent of total caloric intake? and (b) Is the insulin-like growth factor (IGF) axis involved in the effects of dietary fat on LAPC-4 tumor growth in SCID mice?

Author(s): 
Ngo, Tung H.
Barnard, R. James
Cohen, Pinchas
Freedland, Stephen
Tran, Chris
deGregorio, Frank
Elshimali, Yahya I.
Heber, David
Aronson, William J.
Publication Title: 
Veterinary Pathology

Macaques provide an important animal model for the study of hormonal agents and their effects on risk biomarkers for breast cancer. A common criticism of this model is that spontaneous breast cancer has rarely been described in these animals. In this report, we characterize 35 mammary gland lesions ranging from ductal hyperplasia to carcinoma in situ and invasive ductal carcinoma in cynomolgus and rhesus macaques. Based on a retrospective analysis, we estimated the lifetime incidence of mammary gland neoplasia in aged female macaques to be about 6%.

Author(s): 
Wood, C. E.
Usborne, A. L.
Starost, M. F.
Tarara, R. P.
Hill, L. R.
Wilkinson, L. M.
Geisinger, K. R.
Feiste, E. A.
Cline, J. M.
Publication Title: 
Toxicologic Pathology

Ductal morphogenesis of the mammary gland occurs largely in the early pubertal period under the influence of ovarian sex hormones. In this study we characterized developing ductal structures in breast tissue of 14 female prepubertal or early pubertal rhesus monkeys (average age, 2.6 +/- 0.1 years). Serum estradiol concentrations ranged from < 5.0 to 61.2 pg/ml, while progesterone concentrations were low in all animals (< 0.6 ng/ml). No corpora lutea were seen on ovarian histology.

Author(s): 
Wood, Charles E.
Hester, Joy M.
Cline, J. Mark
Publication Title: 
The American Journal of Pathology

Methionine adenosyltransferase (MAT) catalyzes the synthesis of S-adenosylmethionine, the principal methyl donor, and is encoded by MAT1A and MAT2A in mammals. Normal liver expresses MAT1A, which is silenced in hepatocellular carcinoma. We have shown that hepatoma cells overexpressing MAT1A grew slower, but whether this is also true in vivo remains unknown. To investigate the effect of overexpressing MAT1A on in vivo tumorigenesis, we generated stable transfectants of Huh7 cells overexpressing either MAT1A or empty vector.

Author(s): 
Li, Jiaping
Ramani, Komal
Sun, Zhanfeng
Zee, Chishing
Grant, Edward G.
Yang, Heping
Xia, Meng
Oh, Pilsoo
Ko, Kwangsuk
Mato, José M.
Lu, Shelly C.
Publication Title: 
Experimental and Molecular Pathology

Hallmark features of type 2 diabetes mellitus include glucosuria and polyuria. Further, renal aquaporin 2 is pivotal to regulation of fluid excretion and urine osmolality. Accordingly, we tested the hypothesis that the db/db mouse displays increased glucosuria and fluid excretion but reduced urine osmolality in association with decreased renal aquaporin 2 level. In addition, we examined the effect of chromium picolinate (Cr(pic)3) which is purported to improve glycemic control.

Author(s): 
Mozaffari, Mahmood S.
Abdelsayed, Rafik
Liu, Jun Yao
Zakhary, Ibrahim
Baban, Babak
Publication Title: 
Clinical & Experimental Metastasis

Breast cancer (BC) is the most common cancer affecting women in the United States and metastatic breast cancer is the leading cause of death. The role estradiol plays in ER-positive BC is well-documented, but the way it contributes to ER-negative BC remains unclear. In the present study, we utilized an experimental model of BC metastasis into lung by injecting ER-negative murine 4T1 cells into mice via the lateral tail vein.

Author(s): 
Yang, Xujuan
Belosay, Aashvini
Du, Mengyuan
Fan, Timothy M.
Turner, Russell T.
Iwaniec, Urszula T.
Helferich, William G.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The objective of this study was to investigate the effects of the Brazilian Scaptotrigona sp propolis, a widely used folk medicine, in corneal wound healing and inflammation. METHODS: Corneal epithelial defects of 1 mm in diameter were made in the right eyes of Wistar male adult rats by cauterization with silver nitrate sticks. Subsequently, they were divided in two groups (n = 40 rats/group): Brazilian propolis (BP) group was topically treated with a microemulsion containing 1% Brazilian propolis; vehicle (VH) group received the same formulation without propolis.

Author(s): 
Martin, Luiz Fernando Taranta
Rocha, Eduardo Melani
Garcia, Sérgio Britto
Paula, Jayter Silva

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