Kidney Function Tests

Publication Title: 
Die Pharmazie

In an effort to identify a new chemopreventive agent, the present study was conducted to investigate the role of T. chebula in the prevention of ferric nitrilotriacetic acid (Fe- NTA) induced oxidative stress and renal tumorigenesis in Wistar rats. A single application of Fe-NTA (9 mg Fe/kg body weight, intraperitoneally) significantly induced oxidative stress and elevated the marker parameters of tumor promotion. However, the pretreatment of animals with different doses of T.

Author(s): 
Prasad, L.
Khan, T. H.
Jahangir, T.
Sultana, S.
Publication Title: 
American Journal of Nephrology

BACKGROUND: Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening. METHODS: The Heart and Soul Study is a longitudinal study of patients with stable coronary heart disease.

Author(s): 
Bansal, Nisha
Whooley, Mary A.
Regan, Mathilda
McCulloch, Charles E.
Ix, Joachim H.
Epel, Elissa
Blackburn, Elizabeth
Lin, Jue
Hsu, Chi-Yuan
Publication Title: 
American Journal of Nephrology

BACKGROUND: Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening. METHODS: The Heart and Soul Study is a longitudinal study of patients with stable coronary heart disease.

Author(s): 
Bansal, Nisha
Whooley, Mary A.
Regan, Mathilda
McCulloch, Charles E.
Ix, Joachim H.
Epel, Elissa
Blackburn, Elizabeth
Lin, Jue
Hsu, Chi-Yuan
Publication Title: 
Zeitschrift Für Psychotherapie Und Medizinische Psychologie
Author(s): 
Bolland, G.
Publication Title: 
Anaesthesia and Intensive Care

Anaemia, hypoproteinaemia and acidic pH in renal failure patients can alter the pharmacokinetics and pharmacodynamics of anaesthetic agents, resulting in altered dose requirements. We evaluated the induction dose of propofol in adult patients with end-stage renal disease by titrating the hypnotic effect by means of a clinical parameter as well as using a more objective assessment of hypnosis, the Bispectral Index (BIS) monitor. The dose was compared with that for patients with normal renal function.

Author(s): 
Goyal, P.
Puri, G. D.
Pandey, C. K.
Srivastva, S.
Publication Title: 
Kidney International

BACKGROUND: Sodium artesunate is currently used in malaria treatment. Adverse effects of this drug have not been described, probably because they cannot be differentiated from malaria-related effects. METHODS: The effects on renal function of an acute infusion of sodium artesunate (12 mg/kg body weight) were studied in the rat with clearance techniques. We also evaluate the effect of sodium artesunate on chloride lumen-bath flux (Cl Jlb) in the isolated thick ascending limb of the loop of Henle (TALH) microperfused in vitro.

Author(s): 
Campos, S. B.
Rouch, L. H.
Seguro, A. C.
Publication Title: 
The American Journal of Tropical Medicine and Hygiene

Artemether, an efficacious antimalarial drug, effectively prevents patent schistosome infections and morbidity, as established in laboratory models and in clinical trials. In view of concern about the potential long-term toxicity, rats were treated orally with 80 mg/kg artemether once every 2 weeks for 5 months. After the final treatment, routine blood test results were normal except for reversible reductions of reticulocyte counts and reversible increases in hemoglobin levels.

Author(s): 
Xiao, Shuhua
Yang, Yuanqing
You, Qiqing
Utzinger, Jürg
Guo, Huifang
Peiying, Jiao
Mei, Jinying
Guo, Jian
Bergquist, Robert
Tanner, Marcel
Publication Title: 
Journal of Ethnopharmacology

Pharmacological and metabolic effects of ashwagandha (Withania somnifera L. (Solanaceae)) used in Ayurveda as a herbal tonic and health food were studied. Ashwagandha was shown to increase swimming time in rats in physical working capacity test, i.e. rats swimming endurance test. Significant increase in relative heart weight and glycogen content in myocardium and liver was also observed in ashwagandha treated group. Ashwagandha treatment increased the duration of contractility in functional test for the resistance of frog heart muscle towards the toxic action of strophanthin-K.

Author(s): 
Dhuley, J. N.
Publication Title: 
Journal of Ethnopharmacology

Cystone, a polyherbal ayurvedic preparation, was found to protect rats partially but significantly against cisplatin-induced renal toxicity, when given intraperitonially 1 h before cisplatin. At 500 and 1000 microg/ml, it also inhibited lipid peroxidation induced by cisplatin in renal cortical slices by 62.7 and 71.6%, respectively. The rats pretreated with cystone (1000 mg/kg i.p.) had significantly lower blood urea nitrogen (BUN) and serum creatinine (33.8 and 0.92 mg/dl, respectively) compared to cisplatin alone (51.5 and 1.41 mg/dl, respectively).

Author(s): 
Rao, M.
Rao, M. N.
Publication Title: 
Journal of Ethnopharmacology

Pharmacological and metabolic effects of ashwagandha (Withania somnifera L. (Solanaceae)) used in Ayurveda as a herbal tonic and health food were studied. Ashwagandha was shown to increase swimming time in rats in physical working capacity test, i.e. rats swimming endurance test. Significant increase in relative heart weight and glycogen content in myocardium and liver was also observed in ashwagandha treated group. Ashwagandha treatment increased the duration of contractility in functional test for the resistance of frog heart muscle towards the toxic action of strophanthin-K.

Author(s): 
Dhuley, J. N.

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