Lactation

Publication Title: 
Hormones and Behavior

Endocrine disruptors, chemicals that disturb the actions of endogenous hormones, have been implicated in birth defects associated with hormone-dependent development. Phytoestrogens are a class of endocrine disruptors found in plants. In the current study we examined the effects of exposure at various perinatal time periods to genistein, a soy phytoestrogen, on reproductive development and learning in male rats. Dams were fed genistein-containing (5 mg/kg feed) food during both gestation and lactation, during gestation only, during lactation only, or during neither period.

Author(s): 
Ball, Evan R.
Caniglia, Mary Kay
Wilcox, Jenna L.
Overton, Karla A.
Burr, Marra J.
Wolfe, Brady D.
Sanders, Brian J.
Wisniewski, Amy B.
Wrenn, Craige C.
Publication Title: 
Endocrinology

Estrogen receptor (ER) is a key regulator of mammary gland development and is also implicated in breast tumorigenesis. Because ER-mediated activities depend critically on coregulator partner proteins, we have investigated the consequences of reduction or loss of function of the coregulator repressor of ER activity (REA) by conditionally deleting one allele or both alleles of the REA gene at different stages of mammary gland development.

Author(s): 
Park, Sunghee
Zhao, Yuechao
Yoon, Sangyeon
Xu, Jianming
Liao, Lan
Lydon, John
DeMayo, Franco
O'Malley, Bert W.
Katzenellenbogen, Benita S.
Publication Title: 
Breast Cancer Research and Treatment

Breast cancer (BC) is the most common malignancy of women in the developed world. To better understand its pathogenesis, knowledge of normal breast development is crucial, as BC is the result of disregulation of physiologic processes. The aim of this study was to investigate the impact of reproductive life stages on the transcriptional profile of the mammary gland in a primate model.

Author(s): 
Stute, Petra
Sielker, Sonja
Wood, Charles E.
Register, Thomas C.
Lees, Cynthia J.
Dewi, Fitriya N.
Williams, J. Koudy
Wagner, Janice D.
Stefenelli, Ulrich
Cline, J. Mark
Publication Title: 
Breastfeeding Medicine: The Official Journal of the Academy of Breastfeeding Medicine

OBJECTIVES: Despite popular and historical use, there has been little modern research conducted to determine the safety and efficacy of herb use during breastfeeding. The purpose of this study was to systematically review the clinical literature on herbal medicine and lactation. METHODS: The databases PubMed, CAB Abstracts, Cochrane Central Register of Controlled Trials, HealthSTAR, Cumulative Index to Nursing and Allied Health Literature, and Reprotox were systematically searched for human trials from 1970 until 2010. Reference lists from relevant articles were hand-searched.

Author(s): 
Budzynska, Katarzyna
Gardner, Zoë E.
Dugoua, Jean-Jacques
Low Dog, Tieraona
Gardiner, Paula
Publication Title: 
Psychoneuroendocrinology

During breastfeeding or suckling, maternal oxytocin levels are raised by somatosensory stimulation. Oxytocin may, however, also be released by nonnoxious stimuli such as touch, warm temperature etc. in plasma and in cerebrospinal fluid. Consequently, oxytocin may be involved in physiological and behavioral effects induced by social interaction in a more general context. In both male and female rats oxytocin exerts potent physiological antistress effects.

Author(s): 
Uvnäs-Moberg, K.
Publication Title: 
Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion
Author(s): 
Peng, Qing
Publication Title: 
Journal of Nurse-Midwifery

The use of homeopathic remedies for the treatment of mastitis is described. The basic principles of homeopathy are discussed, including the simillimum, the minimum dose, the single remedy, the whole person, the vital force, susceptibility, and constitutional treatment. Homeopathic research trials and papers are examined and discussed. The author explains how homeopathy can be incorporated into midwifery practice and applies this to the treatment of mastitis.

Author(s): 
Castro, M.
Publication Title: 
Journal De Gynécologie, Obstétrique Et Biologie De La Reproduction

Dopaminergic agonists, such as Parlodel((R)), are now widely used to inhibit lactation. However, some countries, such as the United States, no longer use these drugs in this indication because of their sometimes serious adverse effects. In this context, the authors tested a homeopathic treatment designed for parturients unable or not wanting to breastfeed. The APIS MELLIFICA 9 CH and BRYONIA 9 CH combination was chosen for its anti-inflammatory and analgesic effects. 71 patients were included in this double-blind placebo-controlled study.

Author(s): 
Berrebi, A.
Parant, O.
Ferval, F.
Thene, M.
Ayoubi, J. M.
Connan, L.
Belon, P.
Publication Title: 
Journal De Gynécologie, Obstétrique Et Biologie De La Reproduction

OBJECTIVES: To provide an overview of ergot derivatives prescription for lactation inhibition in France, either label (bromocriptine 2.5mg and lisuride 0.2mg) or off-label prescription (dihydroergocryptine and cabergoline). PATIENTS AND METHODS: Analysis based on a questionnaire sent to all 618 French maternity wards in 2009, and prescription modalities from social security reimbursement data in the Rhône-Alpes region. RESULTS: The mean response rate to the questionnaire was 43% and main characteristics of respondents in this sample were very close to those found at the national level.

Author(s): 
Mirkou, A.
Suchovsky, D.
Gouraud, A.
Gillet, A.
Bernard, N.
Descotes, J.
Vial, T.
Publication Title: 
Prescrire International

Breast-feeding is not advisable in certain situations and some women do not want to breast-feed. If the woman does not breast-feed, lactation ceases after one or two weeks. Where does the evaluation of methods used to prevent onset of lactation stand in 2012? To answer this question, we reviewed the available evidence, based on the standard Prescrire methodology. Among the physical methods sometimes proposed, breast binding causes greater discomfort than wearing a bra. Dopamine agonists, such as bromocriptine, are effective in inhibiting lactation.

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