Lactic Acid

Publication Title: 
Chemico-Biological Interactions

Mitochondria play a central role in molecular events leading to tissue damage in ischemia. The present study examines the role of the alcoholic extract of T. chebula (TCE) pretreatment (50 mg/100 g body weight) to attenuate the isoproterenol (ISO) (20mg/100g body wt, sc) induced alterations on heart mitochondrial ultrastucture and function in experimental rats.

Author(s): 
Suchalatha, Subramaniyan
Srinivasan, Periasamy
Devi, Chennam Srinivasulu Shyamala
Publication Title: 
Molecular Aspects of Medicine

The SLC16 gene family has fourteen members. Four (SLC16A1, SLC16A3, SLC16A7, and SLC16A8) encode monocarboxylate transporters (MCT1, MCT4, MCT2, and MCT3, respectively) catalysing the proton-linked transport of monocarboxylates such as l-lactate, pyruvate and ketone bodies across the plasma membrane. SLC16A2 encodes a high affinity thyroid hormone transporter (MCT8) and SLC16A10 an aromatic amino acid transporter (TAT1). The substrates and roles of the remaining eight members are unknown.

Author(s): 
Halestrap, Andrew P.
Publication Title: 
Nucleic Acids Research

The translation of genes encoded in the mitochondrial genome requires specific machinery that functions in the organelle. Among the many mutations linked to human disease that affect mitochondrial translation, several are localized to nuclear genes coding for mitochondrial aminoacyl-transfer RNA synthetases. The molecular significance of these mutations is poorly understood, but it is expected to be similar to that of the mutations affecting mitochondrial transfer RNAs.

Author(s): 
Guitart, Tanit
Picchioni, Daria
PiÒeyro, David
Ribas de Pouplana, LluÌs
Publication Title: 
Obesity Research

OBJECTIVE: To determine whether there is a difference in risk-factor improvement for coronary heart disease (CHD) between the intra-abdominal fat (IF) and subcutaneous fat (SF) obesity phenotypes after weight loss. RESEARCH METHODS AND PROCEDURES: Subjects included 55 mildly obese women (body mass index, 25 to 36 kg/m(2); age range, 34 to 63 years) who had at least two of three CHD risk factors [systolic blood pressure (SBP), >140 mm Hg; total cholesterol (TC), >220 mg/dL; fasting plasma glucose, >110 mg/dL).

Author(s): 
Okura, Tomohiro
Tanaka, Kiyoji
Nakanishi, Tomoko
Lee, Dong Jun
Nakata, Yoshio
Wee, Seung Wan
Shimokata, Hiroshi
Publication Title: 
Journal of Neuro-Oncology

Regardless of their cell type of origin, all aggressive brain tumors, such as malignant gliomas and metastatic tumors produce brain edema, which is an important cause of patient morbidity and mortality. Caloric restriction (CR) has long been recognized as a natural therapy that improves health, promotes longevity, and significantly reduces both the incidence and growth of many tumor types. The aim of present work was to investigate the effect of CR on edema and survival in the mice implanted with U87 gliomas.

Author(s): 
Jiang, Yong-Sheng
Wang, Fu-Rong
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the effect of artemether (Art) on glyceraldehyde-phosphate dehydrogenase (GAPDH), phosphoglycerate kinase (PGK), and pyruvate kinase (PK) of S japanicum. METHODS: Mice infected with schistosome cercariae for 32-38 d were treated ig with Art 100-300 mg.kg-1 and killed 24-72 h after medication for collection of schistosomes. The activities of GAPDH, PGK, and PK of the worms were determined by measuring the formation of NADH or consumption of NAD. The lactate content of the worms was also measured.

Author(s): 
Xiao, S. H.
You, J. Q.
Guo, H. F.
Jiao, P. Y.
Mei, J. Y.
Yao, M. Y.
Feng, Z.
Publication Title: 
The Indian Journal of Medical Research

The effect of pranayama a controlled breathing practice, on exercise tests was studied in athletes in two phases; sub-maximal and maximal exercise tests. At the end of phase I (one year) both the groups (control and experimental) achieved significantly higher work rate and reduction in oxygen consumption per unit work. There was a significant reduction in blood lactate and an increase in P/L ratio in the experimental group, at rest.

Author(s): 
Raju, P. S.
Madhavi, S.
Prasad, K. V.
Reddy, M. V.
Reddy, M. E.
Sahay, B. K.
Murthy, K. J.
Publication Title: 
Indian Journal of Physiology and Pharmacology

A study was undertaken to observe any beneficial effect of yogic practices during training period on the young trainees. 54 trainees of 20-25 years age group were divided randomly in two groups i.e. yoga and control group. Yoga group (23 males and 5 females) was administered yogic practices for the first five months of the course while control group (21 males and 5 females) did not perform yogic exercises during this period. From the 6th to 10th month of training both the groups performed the yogic practices.

Author(s): 
Ray, U. S.
Mukhopadhyaya, S.
Purkayastha, S. S.
Asnani, V.
Tomer, O. S.
Prashad, R.
Thakur, L.
Selvamurthy, W.
Publication Title: 
The Indian Journal of Medical Research

The effect of pranayama a controlled breathing practice, on exercise tests was studied in athletes in two phases; sub-maximal and maximal exercise tests. At the end of phase I (one year) both the groups (control and experimental) achieved significantly higher work rate and reduction in oxygen consumption per unit work. There was a significant reduction in blood lactate and an increase in P/L ratio in the experimental group, at rest.

Author(s): 
Raju, P. S.
Madhavi, S.
Prasad, K. V.
Reddy, M. V.
Reddy, M. E.
Sahay, B. K.
Murthy, K. J.
Publication Title: 
Indian Journal of Physiology and Pharmacology

A study was undertaken to observe any beneficial effect of yogic practices during training period on the young trainees. 54 trainees of 20-25 years age group were divided randomly in two groups i.e. yoga and control group. Yoga group (23 males and 5 females) was administered yogic practices for the first five months of the course while control group (21 males and 5 females) did not perform yogic exercises during this period. From the 6th to 10th month of training both the groups performed the yogic practices.

Author(s): 
Ray, U. S.
Mukhopadhyaya, S.
Purkayastha, S. S.
Asnani, V.
Tomer, O. S.
Prashad, R.
Thakur, L.
Selvamurthy, W.

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