Lactobacillus acidophilus

Publication Title: 
Fish & Shellfish Immunology

This study compares the effects of two Lactobacillus strains, highly adhesive Lactobacillus brevis JCM 1170 (HALB) and less-adhesive Lactobacillus acidophilus JCM 1132 (LALB), on the survival and growth, adhesive gut bacterial communities, immunity, and protection against pathogenic bacterial infection in juvenile hybrid tilapia. During a 5-week feeding trial the fish were fed a diet containing 0 to 10(9) cells/g feed of the two Lactobacillus strains.

Author(s): 
Liu, Wenshu
Ren, Pengfei
He, Suxu
Xu, Li
Yang, Yaling
Gu, Zemao
Zhou, Zhigang
Publication Title: 
Veterinary Immunology and Immunopathology

The goal of this study was to define the impact of colonization of gnotobiotic (Gn) pigs with lactic acid bacteria (LAB) on development of intestinal and systemic B cell responses to human rotavirus (HRV). The LAB-specific and total B cell responses were also assessed. Gn pigs were inoculated with LAB (Lactobacillus acidophilus and L. reuteri) and virulent Wa strain HRV (LAB+HRV+), HRV only (LAB-HRV+), LAB only (LAB+HRV-) or mock (LAB-HRV-).

Author(s): 
Zhang, Wei
Azevedo, Marli S. P.
Gonzalez, Ana M.
Saif, Linda J.
Van Nguyen, Trang
Wen, Ke
Yousef, Ahmed E.
Yuan, Lijuan
Publication Title: 
Vaccine

We evaluated virus-specific B and T cell responses induced by the attenuated Wa (P1A[8]G1) human rotavirus (AttHRV) oral 2-dose vaccine with or without Lactobacillus acidophilus (LA) colonization in neonatal gnotobiotic (Gn) pigs. The AttHRV vaccinated and LA-fed pigs had a significantly higher magnitude of HRV-specific IFN-gamma producing CD8+ T cell responses in ileum and spleen, IgA and IgG antibody-secreting cell responses in ileum, and serum IgM, IgA and IgG antibody and virus neutralizing antibody titers compared to the AttHRV vaccinated pigs without LA colonization.

Author(s): 
Zhang, Wei
Azevedo, Marli S. P.
Wen, Ke
Gonzalez, Ana
Saif, Linda J.
Li, Guohua
Yousef, Ahmed E.
Yuan, Lijuan
Publication Title: 
Veterinary Immunology and Immunopathology

Toll-like receptors (TLR) play an important role in the recognition of microbes by host sentinel cells that leads to the subsequent innate and adaptive immune responses. In this study, we evaluated the patterns of TLR2-, TLR3- and TLR9-expressing antigen presenting cells (APCs) in spleen and blood of gnotobiotic (Gn) pigs after colonization with a mixture of two strains of lactic acid bacteria (LAB), Lactobacillus acidophilus and Lactobacillus reuteri or infection with the virulent human rotavirus (HRV) Wa strain.

Author(s): 
Wen, Ke
Azevedo, Marli S. P.
Gonzalez, Ana
Zhang, Wei
Saif, Linda J.
Li, Guohua
Yousef, Ahmed
Yuan, Lijuan
Publication Title: 
Vaccine

BACKGROUND: Strain-specific effects of probiotics in pro- or anti-inflammatory immune responses have been well recognized. Several proinflammatory Lactobacillus strains have been shown to act as adjuvants to enhance the immunogenicity of vaccines. However, dose effects of probiotics in modulating immune responses are not clearly understood. This study examined the dose effects of Lactobacillus acidophilus (LA) NCFM strain on T cell immune responses to rotavirus vaccination in a gnotobiotic (Gn) pig model.

Author(s): 
Wen, Ke
Li, Guohua
Bui, Tammy
Liu, Fangning
Li, Yanru
Kocher, Jacob
Lin, Lin
Yang, Xingdong
Yuan, Lijuan
Publication Title: 
Beneficial Microbes

Probiotic lactic acid bacteria (LAB) have been shown to alleviate inflammation, enhance the immunogenicity of rotavirus vaccines, or reduce the severity of rotavirus diarrhoea. Although the mechanisms are not clear, the differential Th1/Th2/Th3-driving capacities and modulating effects on cytokine production of different LAB strains may be the key. Our goal was to delineate the influence of combining two probiotic strains of Lactobacillus acidophilus and Lactobacillus reuteri on the development of cytokine responses in neonatal gnotobiotic pigs infected with human rotavirus (HRV).

Author(s): 
Azevedo, M. S. P.
Zhang, W.
Wen, K.
Gonzalez, A. M.
Saif, L. J.
Yousef, A. E.
Yuan, L.
Publication Title: 
Age (Dordrecht, Netherlands)

Ageing changes gut microbiota composition and alters immune system function. Probiotics, prebiotics and synbiotics may improve the health status of elderly individuals by modifying the intestinal environment and the microbiota composition, and by stimulating the immune system. In this work, we studied the effects of synbiotic supplementation on the gut microbiota of healthy elderly volunteers. Fifty-one elders were randomly assigned to consume either a synbiotic dietary supplement or a placebo in addition to their usual diet for a 2-week period.

Author(s): 
Björklund, Marika
Ouwehand, Arthur C.
Forssten, Sofia D.
Nikkilä, Janne
Tiihonen, Kirsti
Rautonen, Nina
Lahtinen, Sampo J.
Publication Title: 
Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine

Splenogastric hygropyrexia syndrome, a common syndome in clinical practice, responds well to the therapy of traditional Chinese medicine (TCM).

Author(s): 
Hu, Ling
Lao, Shao-xian
Kuang, Zao-yuan
Cheng, Ming
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