Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

The purpose of this study was to simultaneously improve the solubility and stability of dihydroartemisinin (DHA) in aqueous solutions by a ternary cyclodextrin system comprised of DHA, hydroxypropyl-?-cyclodextrin (HP-?-CD) and a third auxiliary substance. Solubility and phase solubility studies were carried out to evaluate the solubilizing efficiency of HP-?-CD in association with various auxiliary substances.

Wang, Dan
Li, Haiyan
Gu, Jingkai
Guo, Tao
Yang, Shuo
Guo, Zhen
Zhang, Xueju
Zhu, Weifeng
Zhang, Jiwen
Publication Title: 
British Journal of Anaesthesia

BACKGROUND: Activation of nicotinic receptors with nicotine has been shown to reduce post-surgical pain in clinical and preclinical studies. Choline is a selective agonist at α7-type nicotinic receptors that does not have addictive or sympathetic activating properties. It is anti-nociceptive in animal studies. We conducted a double-blind randomized trial of oral choline supplementation with lecithin to aid in the treatment of pain after gynaecological surgery.

Sidhu, N.
Davies, S.
Nadarajah, A.
Rivera, J.
Whittington, R.
Mercier, R. J.
Virag, L.
Wang, S.
Flood, P.
Publication Title: 
Alternative Medicine Review: A Journal of Clinical Therapeutic

Cholesterol gallstones are among the most common gastrointestinal disorders in Western societies. Individuals with gallstones may experience various gastrointestinal symptoms and are also at risk of developing acute or chronic cholecystitis. Cholecystectomy is the most frequently recommended conventional treatment for symptomatic gallstones. Bile acids (ursodeoxycholic acid or chenodeoxycholic acid) are also used in some cases to dissolve radiolucent stones, but these drugs can cause gastrointestinal side effects and there is a high rate of stone recurrence after treatment is discontinued.

Gaby, Alan R.
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