Lens, Crystalline

Publication Title: 
Planta Medica

Terminalia chebula Retz. has been used in India for a long time to treat many diseases, and its extract was reported to have antidiabetic activity in vivo. In this study, T. chebula methanolic extract (TCE) containing 2.7 % chebulic acid was evaluated for its preventive effects against the formation of advanced glycation end products (AGEs) and endothelial cell dysfunction.

Author(s): 
Lee, Hyun-Sun
Cho, Hong Yon
Park, Kuen-Woo
Kim, In-Hwan
Kim, Jong-Tak
Nam, Mi-Hyun
Lee, Kwang-Won
Publication Title: 
Fundamental & Clinical Pharmacology

Cataract formation represents a serious problem in the elderly and has a large impact on healthcare budget. Aging and cataract formation are relatively complex phenomena, both in vivo and in vitro. Telomeres are special structures at the end of chromosomes. They shorten during each round of replication, and this has been characterized as a mitotic counting mechanism.

Author(s): 
Babizhayev, Mark A.
Vishnyakova, Khava S.
Yegorov, Yegor E.
Publication Title: 
PloS One

Diabetes mellitus is recognized as a leading cause of new cases of blindness. The prevalence of diabetic eye disease is expected to continue to increase worldwide as a result of the dramatic increase in the number of people with diabetes. At present, there is no medical treatment to delay or prevent the onset and progression of cataract or retinopathy, the most common causes of vision loss in diabetics. The plant Emblica officinalis (gooseberry) has been used for thousands of years as a traditional Indian Ayurvedic preparation for the treatment of diabetes in humans.

Author(s): 
Puppala, Muthenna
Ponder, Jessica
Suryanarayana, Palla
Reddy, Geereddy Bhanuprakash
Petrash, J. Mark
LaBarbera, Daniel V.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, the present study was designed to evaluate the polyherbal formulation (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant and cytotoxicity in addition to the evaluation of intraocular penetration of PHF in rabbit eyes using LC-MS/MS.

Author(s): 
Velpandian, Thirumurthy
Gupta, Pankaj
Ravi, Alok Kumar
Sharma, Hanuman Prasad
Biswas, Nihar Ranjan
Publication Title: 
PloS One

Diabetes mellitus is recognized as a leading cause of new cases of blindness. The prevalence of diabetic eye disease is expected to continue to increase worldwide as a result of the dramatic increase in the number of people with diabetes. At present, there is no medical treatment to delay or prevent the onset and progression of cataract or retinopathy, the most common causes of vision loss in diabetics. The plant Emblica officinalis (gooseberry) has been used for thousands of years as a traditional Indian Ayurvedic preparation for the treatment of diabetes in humans.

Author(s): 
Puppala, Muthenna
Ponder, Jessica
Suryanarayana, Palla
Reddy, Geereddy Bhanuprakash
Petrash, J. Mark
LaBarbera, Daniel V.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The polyherbal eye drop (Itone™) is a mixture of aqueous distillates of nineteen traditionally used ingredients that sum up to impart potency to the formulation and make it a useful adjunct in various ocular pathologies. However, as there have been no controlled experimental studies accounting to the above claim, therefore, the present study was designed to evaluate the polyherbal formulation (PHF) for antiangiogenic, anti-inflammatory, anticataract, antioxidant and cytotoxicity in addition to the evaluation of intraocular penetration of PHF in rabbit eyes using LC-MS/MS.

Author(s): 
Velpandian, Thirumurthy
Gupta, Pankaj
Ravi, Alok Kumar
Sharma, Hanuman Prasad
Biswas, Nihar Ranjan
Publication Title: 
Journal of Ethnopharmacology

ETHNOPHARMACOLOGICAL RELEVANCE: Aegle marmelos (L.) Corr. Serr. (Aegle marmelos) leaves were extensively used in the Ayurvedic, Unani and Siddha systems of Indian medicine as an anti-diabetic agent, which serves as hypoglycemic agent. However, the significance of this plant on secondary complications of diabetes such as cataract remained unknown. The aim of the study was to investigate the possible anti-cataractous activity of Aegle marmelos against streptozotocin (STZ) induced diabetic cataract in rats.

Author(s): 
Sankeshi, Venu
Kumar, P. Anil
Naik, R. Ravindar
Sridhar, G.
Kumar, M. Praveen
Gopal, V. V. Hara
Raju, T. Naga
Publication Title: 
Molecular Vision

PURPOSE: To determine comparative effects of ultraviolet (UV)-A irradiation on structural and functional properties of wild type (WT) alphaB-crystallin and its three deamidated mutant proteins (alphaB-Asn78Asp, alphaB-Asn146Asp, and alphaB-Asn78/146Asp). METHODS: Three deamidated mutants previously generated from recombinant WT alphaB-crystallin, using a site-specific mutagenesis procedure as previously described [32], were used. The WT alphaB-crystallin and its three deamidated species were exposed to UV-A light (320-400 nm) at intensities of 20 or 50 J/cm(2).

Author(s): 
Mafia, Kerri
Gupta, Ratna
Kirk, Marion
Wilson, L.
Srivastava, O. P.
Barnes, Stephen
Publication Title: 
Molecular Vision

PURPOSE: The purpose was to characterize the properties of a proteinase activity associated with betaA3-crystallin, which was isolated from the alpha-crystallin fraction of human lenses. METHODS: An inactive, Arg-bond hydrolyzing proteinase in the alpha-crystallin fraction, which was isolated from the water soluble (WS) protein fraction of 60- to 70-year-old human lenses, was activated by sodium deoxycholate treatment.

Author(s): 
Srivastava, O. P.
Srivastava, K.
Chaves, J. M.
Publication Title: 
Molecular Vision

PURPOSE: With aging, lens crystallins undergo post-translational modifications (PTMs) and these modifications are believed to play a major role in age-related cataract development. The purpose of the present study was to determine the protein profiles of crystallins and their PTMs in the cortical and nuclear regions within an aging human lens to gain a better understanding about changes in crystallins as fiber cells migrate from cortical to nuclear region.

Author(s): 
Asomugha, C. O.
Gupta, R.
Srivastava, O. P.

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