Leukemia, Experimental

Publication Title: 
Progress in Clinical and Biological Research
Stevenson, D. E.
Publication Title: 
In Vivo (Athens, Greece)

Ampelopsis cantoniensis (AC) has been used as a folk medicine for reducing pain in the Taiwanese population. Our previous studies have shown that the crude extract of AC induced apoptosis in human promyelocytic leukemia HL-60 cells. In this study, the in vivo effects of AC on leukemia WEHI-3 cells and immune responses such as phagocytosis and natural killer (NK) cell activity were investigated. The weights of the livers and spleens were decreased in the AC-treated groups compared to the control groups.

Tan, Tzu-Wei
Lin, Yuh-Tzy
Yang, Jai-Sing
Lu, Chi-Cheng
Chiang, Jo-Hua
Wu, Chang-Lin
Lin, Jing-Pin
Tang, Nou-Ying
Yeh, Chin-Chung
Fan, Ming-Jen
Chung, Jing-Gung
Publication Title: 
Asian Pacific journal of cancer prevention: APJCP

Non-toxic stimulation of dendritic cells (DCs), which are central immunomodulators, may aid the prevention of cancer. Furthermore, induction of apoptosis in cancer cells by anticancer agents contributes to the induction of DC maturation. We previously reported that extracts from Pinus parviflora Sieb. et Zucc pine cone and Mucuna seed induce differentiation of mouse bone marrow cells into mature dendritic cells and also induce apoptosis in various human cancer cell lines.

Nakaya, Kazuyasu
Nabata, Yuri
Ichiyanagi, Takashi
An, Wei Wei
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