Leukemia

Publication Title: 
Complementary Therapies in Nursing & Midwifery
Author(s): 
Stringer, J.
Publication Title: 
Psycho-Oncology

OBJECTIVE: The objective is to identify whether single 20 min massage sessions were safe and effective in reducing stress levels of isolated haematological oncology patients. DESIGN: Based on a randomised controlled trial, 39 patients were randomised to aromatherapy, massage or rest (control) arm. MEASURES: The measures were serum cortisol and prolactin levels, quality of life (EORTC QLQ-C30) and semi-structured interviews. Primary outcome measure was the fall in serum cortisol levels.

Author(s): 
Stringer, Jacqui
Swindell, Ric
Dennis, Michael
Publication Title: 
Pharmacoepidemiology and Drug Safety

PURPOSE: The use of complementary and alternative medicine (CAM) in cancer treatments is widespread with substantial number of patients deserting conventional cancer therapies in favour of unproven methods. The present study aimed at discovering the prevalence of use of CAM cancer therapies in leukaemia patients visiting haematology clinic of a north Indian tertiary care hospital. METHODS: 533 consecutive leukaemia patients were interviewed.

Author(s): 
Gupta, M.
Shafiq, N.
Kumari, S.
Pandhi, P.
Publication Title: 
Cell Proliferation

OBJECTIVES: Gymnema montanum Hook, an Indian Ayurvedic medicinal plant, is used traditionally to treat a variety of ailments. Here, we report anti-cancer effects and molecular mechanisms of ethanolic extract of G. montanum (GLEt) on human leukaemia HL-60 cells, compared to peripheral blood mononuclear cells. MATERIALS AND METHODS: HL-60 cells were treated with different concentrations of GLEt (10-50 μg/ml) and cytotoxicity was assessed by MTT assay. Levels of lipid peroxidation, antioxidants, mitochondrial membrane potential and caspase-3 were measured.

Author(s): 
Ramkumar, K. M.
Manjula, C.
Elango, B.
Krishnamurthi, K.
Saravana Devi, S.
Rajaguru, P.
Publication Title: 
Integrative Cancer Therapies

BACKGROUND: International evidence indicates that caretakers of pediatric leukemia patients are increasingly using complementary and alternative medicine (CAM) therapies. Such a trend has never been substantiated in the Arab world. OBJECTIVE: Examine the frequency, types, modes, and reasons of CAM use among pediatric leukemia patients in Lebanon. METHODS: A cross-sectional design was utilized to survey (by phone) the caregivers of all pediatric leukemia patients on the rosters of the 2 largest cancer treatment facilities in Lebanon for years 2005-2009.

Author(s): 
Naja, Farah
Alameddine, Mohamad
Abboud, Miguel
Bustami, Dunia
Al Halaby, Ruba
Publication Title: 
Journal of the National Cancer Institute

BACKGROUND: 1,25-Dihydroxyvitamin D(3) inhibits growth of several types of human cancer cells in vitro, but its therapeutic use is hampered because it causes hypercalcemia. 19-nor-1,25-Dihydroxyvitamin D(2) (paricalcitol) is a noncalcemic vitamin D analog that is approved by the Food and Drug Administration for the treatment of secondary hyperparathyroidism. We investigated the antitumor activity and mechanism of action of paricalcitol in vitro and in vivo. METHODS: Effects of paricalcitol on proliferation, the cell cycle, differentiation, and apoptosis were examined in cancer cell lines.

Author(s): 
Kumagai, Takashi
O'Kelly, James
Said, Jonathan W.
Koeffler, H. Phillip
Publication Title: 
Pediatric Research

Music is widely used to enhance well-being. We wished to assess music's effect on pediatric oncology outpatients. Patients who had leukemia and were in maintenance or consolidation outpatient treatment served as their own control at two visits. At visit 1, children rested for 20 min; at visit 2, for 20 min they listened to music designed to increase vitality and improve heart rate variability (HRV).

Author(s): 
Kemper, Kathi J.
Hamilton, Craig A.
McLean, Thomas W.
Lovato, James
Publication Title: 
Expert Review of Anticancer Therapy

Patients with leukemia often seek additional treatments not prescribed by their oncologist in an effort to improve their cancer treatment outcome or to manage symptoms. Complementary therapies are used in conjunction with traditional cancer treatments to decrease symptoms and side effects associated with cancer or cancer treatment, and to improve patients' overall quality of life. Complementary therapies are distinct from so-called 'alternative' therapies, which are unproven, ineffective and may postpone or interfere with mainstream cancer treatment.

Author(s): 
Wesa, Kathleen M.
Cassileth, Barrie R.
Publication Title: 
Blood

Targeting cancer stem cells is of paramount importance in successfully preventing cancer relapse. Recently, in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells. We show here that Δ(12)-PGJ(3), a novel and naturally produced CyPG from the dietary fish-oil ω-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA; 20:5) alleviates the development of leukemia in 2 well-studied murine models of leukemia.

Author(s): 
Hegde, Shailaja
Kaushal, Naveen
Ravindra, Kodihalli C.
Chiaro, Christopher
Hafer, Kelsey T.
Gandhi, Ujjawal H.
Thompson, Jerry T.
van den Heuvel, John P.
Kennett, Mary J.
Hankey, Pamela
Paulson, Robert F.
Prabhu, K. Sandeep
Publication Title: 
Expert Review of Anticancer Therapy

Patients with leukemia often seek additional treatments not prescribed by their oncologist in an effort to improve their cancer treatment outcome or to manage symptoms. Complementary therapies are used in conjunction with traditional cancer treatments to decrease symptoms and side effects associated with cancer or cancer treatment, and to improve patients' overall quality of life. Complementary therapies are distinct from so-called 'alternative' therapies, which are unproven, ineffective and may postpone or interfere with mainstream cancer treatment.

Author(s): 
Wesa, Kathleen M.
Cassileth, Barrie R.

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