Leukocytes, Mononuclear

Publication Title: 
Psychoneuroendocrinology

OBJECTIVE: To summarise and discuss the association between telomerase activity and psychological stress, mental disorders and lifestyle factors. METHOD: A systematic review was carried out to identify prospective or retrospective studies and interventions published up to June 2015 that reported associations between telomerase activity and psychological stress, mental disorders and lifestyle factors. Electronic data bases of PubMed, ProQuest, CINAHL and Google Scholar were searched.

Author(s): 
Deng, W.
Cheung, S. T.
Tsao, S. W.
Wang, X. M.
Tiwari, A. F. Y.
Publication Title: 
Psychoneuroendocrinology

OBJECTIVE: To summarise and discuss the association between telomerase activity and psychological stress, mental disorders and lifestyle factors. METHOD: A systematic review was carried out to identify prospective or retrospective studies and interventions published up to June 2015 that reported associations between telomerase activity and psychological stress, mental disorders and lifestyle factors. Electronic data bases of PubMed, ProQuest, CINAHL and Google Scholar were searched.

Author(s): 
Deng, W.
Cheung, S. T.
Tsao, S. W.
Wang, X. M.
Tiwari, A. F. Y.
Publication Title: 
Psychoneuroendocrinology

OBJECTIVE: To summarise and discuss the association between telomerase activity and psychological stress, mental disorders and lifestyle factors. METHOD: A systematic review was carried out to identify prospective or retrospective studies and interventions published up to June 2015 that reported associations between telomerase activity and psychological stress, mental disorders and lifestyle factors. Electronic data bases of PubMed, ProQuest, CINAHL and Google Scholar were searched.

Author(s): 
Deng, W.
Cheung, S. T.
Tsao, S. W.
Wang, X. M.
Tiwari, A. F. Y.
Publication Title: 
PloS One

Bioactive bone substitute materials are a valuable alternative to autologous bone transplantations in the repair of skeletal defects. However, clinical studies have reported varying success rates for many commonly used biomaterials. While osteoblasts have traditionally been regarded as key players mediating osseointegration, increasing evidence suggests that bone-resorbing osteoclasts are of crucial importance for the longevity of applied biomaterials.

Author(s): 
Keller, Johannes
Brink, Silja
Busse, Bjˆrn
Schilling, Arndt F.
Schinke, Thorsten
Amling, Michael
Lange, Tobias
Publication Title: 
Cell Reports

Telomeric DNA repeats are lost as normal somatic cells replicate. When telomeres reach a critically short length, a DNA damage signal is initiated, inducing cell senescence. Some studies have indicated that telomere length correlates with mortality, suggesting that telomere length contributes to human life span; however, other studies report no correlation, and thus the issue remains controversial. Domestic dogs show parallels in telomere biology to humans, with similar telomere length, telomere attrition, and absence of somatic cell telomerase activity.

Author(s): 
Fick, Laura J.
Fick, Gordon H.
Li, Zichen
Cao, Eric
Bao, Bo
Heffelfinger, Doug
Parker, Heidi G.
Ostrander, Elaine A.
Riabowol, Karl
Publication Title: 
Psychoneuroendocrinology

We previously reported that psychological stress is linked to and possibly accelerates cellular aging, as reflected by lower PBMC telomerase and shortened telomeres. Psychological stress is a major risk factor for cardiovascular disease (CVD), with multiple behavioral and physiological mediators. Telomere shortness has been associated with CVD, but the relationship between low telomerase activity, a potential precursor to telomere shortening, and CVD risk factors has not been examined in humans.

Author(s): 
Epel, Elissa S.
Lin, Jue
Wilhelm, Frank H.
Wolkowitz, Owen M.
Cawthon, Richard
Adler, Nancy E.
Dolbier, Christyn
Mendes, Wendy B.
Blackburn, Elizabeth H.
Publication Title: 
Molecular Psychiatry

Telomeres are DNA-protein complexes that cap linear DNA strands, protecting DNA from damage. When telomeres critically shorten, cells become susceptible to senescence and apoptosis. Telomerase, a cellular ribonucleoprotein enzyme, rebuilds the length of telomeres and promotes cellular viability. Leukocyte telomeres are reportedly shortened in major depression, but telomerase activity in depression has not been previously reported.

Author(s): 
Wolkowitz, O. M.
Mellon, S. H.
Epel, E. S.
Lin, J.
Reus, V. I.
Rosser, R.
Burke, H.
Compagnone, M.
Nelson, J. C.
Dhabhar, F. S.
Blackburn, E. H.
Publication Title: 
The Lancet Oncology

BACKGROUND: Telomeres are protective DNA-protein complexes at the end of linear chromosomes that promote chromosomal stability. Telomere shortness in human beings is emerging as a prognostic marker of disease risk, progression, and premature mortality in many types of cancer, including breast, prostate, colorectal, bladder, head and neck, lung, and renal cell. Telomere shortening is counteracted by the cellular enzyme telomerase. Lifestyle factors known to promote cancer and cardiovascular disease might also adversely affect telomerase function.

Author(s): 
Ornish, Dean
Lin, Jue
Daubenmier, Jennifer
Weidner, Gerdi
Epel, Elissa
Kemp, Colleen
Magbanua, Mark Jesus M.
Marlin, Ruth
Yglecias, Loren
Carroll, Peter R.
Blackburn, Elizabeth H.
Publication Title: 
American Journal of Obstetrics and Gynecology

OBJECTIVE: In adults, one of the major determinants of leukocyte telomere length (LTL), a predictor of age-related diseases and mortality, is cumulative psychosocial stress exposure. More recently we reported that exposure to maternal psychosocial stress during intrauterine life is associated with LTL in young adulthood. The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length.

Author(s): 
Entringer, Sonja
Epel, Elissa S.
Lin, Jue
Buss, Claudia
Shahbaba, Babak
Blackburn, Elizabeth H.
Simhan, Hyagriv N.
Wadhwa, Pathik D.
Publication Title: 
American Journal of Obstetrics and Gynecology

OBJECTIVE: In adults, one of the major determinants of leukocyte telomere length (LTL), a predictor of age-related diseases and mortality, is cumulative psychosocial stress exposure. More recently we reported that exposure to maternal psychosocial stress during intrauterine life is associated with LTL in young adulthood. The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length.

Author(s): 
Entringer, Sonja
Epel, Elissa S.
Lin, Jue
Buss, Claudia
Shahbaba, Babak
Blackburn, Elizabeth H.
Simhan, Hyagriv N.
Wadhwa, Pathik D.

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