Li-Fraumeni Syndrome

Publication Title: 
Cancer Biology & Therapy

Studies were conducted to directly test whether the introduction of telomerase protects cancer-prone human mammary epithelial cells from chromosomal instability and spontaneous immortalization. Using a model for Li Fraumeni Syndrome (LFS), infection of human telomerase resulted in maintenance of telomere lengths, extension of in vitro lifespan, and prevention of spontaneous immortalization.

Author(s): 
Elmore, Lynne W.
Turner, Kristi C.
Gollahon, Lauren S.
Landon, Melissa R.
Jackson-Cook, Colleen K.
Holt, Shawn E.
Subscribe to RSS - Li-Fraumeni Syndrome