Lidocaine

Publication Title: 
PLoS medicine

BACKGROUND: Postherpetic neuralgia (PHN) is a complication of acute herpes zoster, which is emerging as a preferred clinical trial model for chronic neuropathic pain. Although there are published meta-analyses of analgesic therapy in PHN, and neuropathic pain in general, the evidence base has been substantially enhanced by the recent publication of several major trials. Therefore, we have conducted a systematic review and meta-analysis for both efficacy and adverse events of analgesic therapy for PHN.

Author(s): 
Hempenstall, Kathleen
Nurmikko, Turo J.
Johnson, Robert W.
A'Hern, Roger P.
Rice, Andrew S. C.
Publication Title: 
PLoS medicine

BACKGROUND: Postherpetic neuralgia (PHN) is a complication of acute herpes zoster, which is emerging as a preferred clinical trial model for chronic neuropathic pain. Although there are published meta-analyses of analgesic therapy in PHN, and neuropathic pain in general, the evidence base has been substantially enhanced by the recent publication of several major trials. Therefore, we have conducted a systematic review and meta-analysis for both efficacy and adverse events of analgesic therapy for PHN.

Author(s): 
Hempenstall, Kathleen
Nurmikko, Turo J.
Johnson, Robert W.
A'Hern, Roger P.
Rice, Andrew S. C.
Publication Title: 
Quintessence International (Berlin, Germany: 1985)

OBJECTIVE: Burning mouth syndrome (BMS) is a common chronic pain condition that lacks a satisfactory treatment approach. This systematic review was designed to examine the effects of acupuncture or acupoint injection on the management of BMS and to evaluate the evidence supporting the use of acupuncture therapy for BMS in clinical practice.

Author(s): 
Yan, Zhimin
Ding, Ning
Hua, Hong
Publication Title: 
Cancer Nursing

BACKGROUND: Transarterial chemoembolization (TACE) is an established treatment in managing liver primary neoplasms or liver metastases. Postembolization syndrome (PES) is a common adverse event defined as fever without associated sepsis, pain in the right upper quadrant, and nausea and/or vomiting. OBJECTIVE: This integrative review aims to identify effective management strategies for PES or one of its characterizing symptoms (fever, pain, and nausea and/or vomiting). METHODS: Searches of electronic databases MEDLINE, EMBASE, and CINAHL were conducted.

Author(s): 
Blackburn, Helen
West, Sandra
Publication Title: 
Journal of Pain & Palliative Care Pharmacotherapy

The Cochrane Library of Systematic Reviews is published quarterly. Issue 3 2007 contains 3197 complete reviews, 1744 protocols for reviews in production and 6312 one-page summaries of systematic reviews published in the general medical literature. In addition there are citations of 503,000 randomized controlled trials, and 9628 cited papers in the Cochrane methodology register. The health technology assessment database contains 6817 citations. This edition of the Library contains 103 new reviews of which 11 have potential relevance for practitioners in pain and palliative medicine.

Author(s): 
Wiffen, Philip J.
Publication Title: 
Arzneimittel-Forschung

The pharmacological actions of N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate (SUN 1165), a new antiarrhythmic agent, on the central nervous system were studied in various experimental animals as compared with those of disopyramide, mexiletine and lidocaine, and the following results were obtained. 1. Acute toxicity of SUN 1165 in mice was similar to that of mexiletine, and twice as potent as compared with that of disopyramide and lidocaine.

Author(s): 
Hirotsu, I.
Kihara, T.
Nakamura, S.
Hattori, Y.
Hatta, M.
Kitakaze, Y.
Takahama, K.
Hashimoto, Y.
Miyata, T.
Ishihara, T.
Publication Title: 
Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Author(s): 
Wessels, I. F.
Najjar, M. F.
Publication Title: 
Postgraduate Medical Journal

A total of 124 subjects who were undergoing routine endoscopy were randomly assigned to one of three groups. All three groups received lignocaine throat spray. The first group additionally received midazolam, the second received hypnosis, whilst the third only received lignocaine throat spray. Although hypnotized patients were deemed by an independent observer to be less agitated than the other two groups (p < 0.03), they reported the gastroscopy to be significantly more uncomfortable (p < 0.042) and scored higher in their memory for the procedure (p < 0.001).

Author(s): 
Conlong, P.
Rees, W.
Publication Title: 
European Journal of Anaesthesiology

We investigated the effect of a small dose of midazolam, ketamine, droperidol or lidocaine on the propofol dose required for hypnosis during induction of general anaesthesia. These drugs were randomly administered to 100 patients about to undergo scheduled surgery. Propofol was then infused at a rate of 250 microg kg-1 min-1 and the hypnotic dose to produce hypnosis was evaluated.

Author(s): 
Adachi, Y. U.
Uchihashi, Y.
Watanabe, K.
Satoh, T.
Publication Title: 
Journal of Basic and Clinical Physiology and Pharmacology

We studied the interactions between a local anesthetic agent, lidocaine, and two general anesthetic drugs, propofol and ketamine, in mice. We used two end points: hypnosis, reflected by loss of the righting reflex, and death. The ED50 for hypnosis and the LD50 were determined for each drug separately, and a dose-response curve was prepared for each drug, using combinations of propofol-lidocane and ketamine-lidocaine at three different dose ratios.

Author(s): 
Barak, M.
Ben-Shlomo, I.
Katz, Y.

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