Lignans

Publication Title: 
Biogerontology

The present study investigated the anti-ageing activity of sesamin and its effect on gene expression of superoxide dismutase (SOD), catalase (CAT), methuselah (Mth) and Rpn11 in Drosophila melanogaster. Results demonstrated that 0.2†% sesamin in diet prolonged the mean lifespan of OR wild fruit flies by 12†%, accompanied by up-regulation of SOD1, SOD2, CAT and Rpn11. Sesamin at 0.2†% in diet also attenuated paraquat-induced neurodegeneration with up-regulation of SOD1, SOD2 and Rpn11 in OR wild fruit flies.

Author(s): 
Zuo, Yuanyuan
Peng, Cheng
Liang, Yintong
Ma, Ka Ying
Chan, Ho Yin Edwin
Huang, Yu
Chen, Zhen-Yu
Publication Title: 
Journal of Pharmaceutical and Biomedical Analysis

Sesamum (Sesamum indicum) seed and its oil have been in use in Indian traditional medicine, 'Ayurveda' since antiquity. However, there has been no attempt to standardize the polyherbal formulations containing sesamum oil as the main ingredient in terms of its active principle or marker compound. Biologically active lignans in sesamum oil are identified as the marker compound for the oil and its formulations.

Author(s): 
Sukumar, Divya
Arimboor, Ranjith
Arumughan, C.
Publication Title: 
PloS One

Estrogens produce biological effects by interacting with two estrogen receptors, ERalpha and ERbeta. Drugs that selectively target ERalpha or ERbeta might be safer for conditions that have been traditionally treated with non-selective estrogens. Several synthetic and natural ERbeta-selective compounds have been identified. One class of ERbeta-selective agonists is represented by ERB-041 (WAY-202041) which binds to ERbeta much greater than ERalpha.

Author(s): 
Paruthiyil, Sreenivasan
Cvoro, Aleksandra
Zhao, Xiaoyue
Wu, Zhijin
Sui, Yunxia
Staub, Richard E.
Baggett, Scott
Herber, Candice B.
Griffin, Chandi
Tagliaferri, Mary
Harris, Heather A.
Cohen, Isaac
Bjeldanes, Leonard F.
Speed, Terence P.
Schaufele, Fred
Leitman, Dale C.
Publication Title: 
Planta Medica

Cancer is a leading cause of death worldwide, and the numbers of new cancer cases are expected to continue to rise. The main goals of cancer therapy include removing the primary tumor, preventing the spread of distant metastases, and improving survival and quality of life for the patients. To attain these goals of cancer therapy, the combination of different chemotherapeutics, as opposed to the conventional single-agent treatment, is an emerging area of research.

Author(s): 
Virk-Baker, Mandeep K.
Nagy, Tim R.
Barnes, Stephen
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

Chronic airway inflammation is a hallmark of asthma, an immune-based disease with great societal impact. Honokiol (HNK), a phenolic neurotransmitter receptor (γ-aminobutyric acid type A) agonist purified from magnolia, has anti-inflammatory properties, including stabilization of inflammation in experimentally induced arthritis. The present study tested the prediction that HNK could inhibit the chronic inflammatory component of allergic asthma.

Author(s): 
Munroe, Melissa E.
Businga, Thomas R.
Kline, Joel N.
Bishop, Gail A.
Publication Title: 
Fitoterapia

A new labdane-diterpene, viteagnusin I (1), together with 23 known phytoconstituents were isolated from the fruits of Vitex agnus-castus L, and their structures characterized by spectroscopic methods (NMR and MS). The known compounds include ten flavonoids, five terpenoids, three neolignans, and four phenolic compounds, as well as one glyceride. Biological evaluation identified apigenin, 3-methylkaempferol, luteolin, and casticin as weak ligands of delta and mu opioid receptors, exhibiting dose-dependent receptor binding.

Author(s): 
Chen, Shao-Nong
Friesen, J. Brent
Webster, Donna
Nikolic, Dejan
van Breemen, Richard B.
Wang, Z. Jim
Fong, Harry H. S.
Farnsworth, Norman R.
Pauli, Guido F.
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology

This study examined the effect of schisandrin, one of the major lignans isolated from Schisandra chinensis, on spontaneous contraction in rat colon and its possible mechanisms. Schisandrin produced a concentration-dependent inhibition (EC₅₀=1.66 μM) on the colonic spontaneous contraction.

Author(s): 
Yang, Jiaming
Ip, Paul S. P.
Yeung, John H. K.
Che, Chun-Tao
Publication Title: 
Journal of Neuroinflammation

BACKGROUND: The bark of magnolia has been used in Oriental medicine to treat a variety of remedies, including some neurological disorders. Magnolol (Mag) and honokiol (Hon) are isomers of polyphenolic compounds from the bark of Magnolia officinalis, and have been identified as major active components exhibiting anti-oxidative, anti-inflammatory, and neuroprotective effects.

Author(s): 
Chuang, Dennis Y.
Chan, Ming-Huan
Zong, Yijia
Sheng, Wenwen
He, Yan
Jiang, Jing Hua
Simonyi, Agnes
Gu, Zezong
Fritsche, Kevin L.
Cui, Jiankun
Lee, James C.
Folk, William R.
Lubahn, Dennis B.
Sun, Albert Y.
Sun, Grace Y.
Publication Title: 
Phytochemical analysis: PCA

Five lignans, phillyrin (1), pinoresinol-beta-D-glucoside (2), pinoresinol di-beta-D-glucoside (3), phillyrin-2-O-beta-D-glucoside (6), phillyrin-6-O-beta-D-glucoside (7), and three secoiridoids, oleuropein (4), ligustroside (5) and angustifolioside B (8), have been isolated from the root bark of Chionanthus virginicus L. (Oleaceae), a raw material used in the commercial preparation of homeopathy tinctures. Compound 6 is a new lignan, and compounds 2, 3, 4, 5, 7 and 8 are described for the first time in the title plant.

Author(s): 
Boyer, Laurent
Elias, Riad
Taoubi, Khalil
Debrauwer, Laurent
Faure, Robert
Baghdikian, Béatrice
Balansard, Guy
Publication Title: 
Biological Research

Schisandra propinqua (Wall.) Baill.(Schisandraceae) is widely used as a Chinese folk medicine. In this study, activity-guided fractionation of the ethanol extract from the stem of Schisandra propinqua led to the isolation of four extracts. Subsequently, a neolignan 4,4-di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol was isolated from the EtOAc part of the stem of Schisandra propinqua, the free radical scavenging activities of which were researched in vitro.

Author(s): 
Huang, Feng
Xu, Lijia
Ganggang, Shi

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