Lipoproteins, VLDL

Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Triphala (Terminalia chebula, Terminalia belerica, and Emblica officinalis) on total cholesterol, Low density lipoprotein (LDL), Very low density lipoprotein (VLDL), High density lipoprotein (HDL) and free fatty acid in experimentally induced hypercholesteremic rats.

Author(s): 
Saravanan, Selvaraj
Srikumar, Ramasundaram
Manikandan, Sundaramahalingam
Jeya Parthasarathy, Narayanaperumal
Sheela Devi, Rathinasamy
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Triphala (Terminalia chebula, Terminalia belerica, and Emblica officinalis) on total cholesterol, Low density lipoprotein (LDL), Very low density lipoprotein (VLDL), High density lipoprotein (HDL) and free fatty acid in experimentally induced hypercholesteremic rats.

Author(s): 
Saravanan, Selvaraj
Srikumar, Ramasundaram
Manikandan, Sundaramahalingam
Jeya Parthasarathy, Narayanaperumal
Sheela Devi, Rathinasamy
Publication Title: 
Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan

Hypercholesteremia is one of the risk factors for coronary artery disease. The present study highlights the efficacy of Ayurvedic herbal formulation Triphala (Terminalia chebula, Terminalia belerica, and Emblica officinalis) on total cholesterol, Low density lipoprotein (LDL), Very low density lipoprotein (VLDL), High density lipoprotein (HDL) and free fatty acid in experimentally induced hypercholesteremic rats.

Author(s): 
Saravanan, Selvaraj
Srikumar, Ramasundaram
Manikandan, Sundaramahalingam
Jeya Parthasarathy, Narayanaperumal
Sheela Devi, Rathinasamy
Publication Title: 
Pakistan journal of biological sciences: PJBS

The successful use of Ayurvedic medicines is for many years but there is no guideline for studying the toxicity of these preparations through preclinical or clinical investigations. The present study was conducted to evaluate the effect of conventionally prepared Sulavajrini Vatika (SBB), an Ayurvedic formulation on various biochemical parameters of experimental animals after chronic administration. The animal used was albino rats (Rattus norvegicus: Sprague-Dawley strain) and SBB was administered orally at a single dose of 100 mg kg(-1) b.wt. day(-1), up to 62 days.

Author(s): 
Kundu, N. Krishna
Ullah, M. Obayed
Hamid, Kaiser
Urmi, Kaniz Fatima
Bulbul, Israt Jahan
Khan, Muhammad Atikul Islam
Akter, Momita
Choudhuri, M. S. K.
Publication Title: 
The Journal of Pharmacology and Experimental Therapeutics

Liver X receptor (LXR) agonists have the potential to treat atherosclerosis based on their ability to enhance reverse cholesterol transport. However, their side effects, such as induction of liver lipogenesis and triglyceridemia, may limit their pharmaceutical development.

Author(s): 
Peng, Dacheng
Hiipakka, Richard A.
Dai, Qing
Guo, Jian
Reardon, Catherine A.
Getz, Godfrey S.
Liao, Shutsung
Publication Title: 
Archives of Biochemistry and Biophysics

Elevated blood triacylglycerol (TG) is a significant contributing factor to the current epidemic of obesity-related health disorders, including type-2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. The observation that mice lacking the enzyme sn-glycerol-3-phosphate acyltransferase are protected from insulin resistance suggests the possibility that the regulation of TG synthesis be a target for therapy. Five-week-old Zucker Diabetic Fatty (ZDF) rats were fed a diet containing (R)-alpha-lipoic acid (LA, approximately 200mg/kg body weight per day) for 5 weeks.

Author(s): 
Butler, Judy A.
Hagen, Tory M.
Moreau, Régis
Publication Title: 
The Journal of Biological Chemistry

Loss of ABCA1 activity in Tangier disease (TD) is associated with abnormal apoB lipoprotein (Lp) metabolism in addition to the complete absence of high density lipoprotein (HDL). We used hepatocyte-specific ABCA1 knock-out (HSKO) mice to test the hypothesis that hepatic ABCA1 plays dual roles in regulating Lp metabolism and nascent HDL formation. HSKO mice recapitulated the TD lipid phenotype with postprandial hypertriglyceridemia, markedly decreased LDL, and near absence of HDL.

Author(s): 
Chung, Soonkyu
Timmins, Jenelle M.
Duong, Myngan
Degirolamo, Chiara
Rong, Shunxing
Sawyer, Janet K.
Singaraja, Roshni R.
Hayden, Michael R.
Maeda, Nobuyo
Rudel, Lawrence L.
Shelness, Gregory S.
Parks, John S.
Publication Title: 
Journal of Lipid Research

In Tangier disease, absence of ATP binding cassette transporter A1 (ABCA1) results in reduced plasma HDL and elevated triglyceride (TG) levels. We hypothesized that hepatocyte ABCA1 regulates VLDL TG secretion through nascent HDL production. Silencing of ABCA1 expression in oleate-stimulated rat hepatoma cells resulted in: 1) decreased large nascent HDL (>10 nm diameter) and increased small nascent HDL (<10 nm) formation, 2) increased large buoyant VLDL1 particle secretion, and 3) decreased phosphatidylinositol-3 (PI3) kinase activation.

Author(s): 
Chung, Soonkyu
Gebre, Abraham K.
Seo, Jeongmin
Shelness, Gregory S.
Parks, John S.
Publication Title: 
Hepatology (Baltimore, Md.)

Very low-density lipoprotein (VLDL) secretion provides a mechanism to export triglycerides (TG) from the liver to peripheral tissues, maintaining lipid homeostasis. In nonalcoholic fatty liver disease (NAFLD), VLDL secretion disturbances are unclear. Methionine adenosyltransferase (MAT) is responsible for S-adenosylmethionine (SAMe) synthesis and MAT I and III are the products of the MAT1A gene. Deficient MAT I and III activities and SAMe content in the liver have been associated with NAFLD, but whether MAT1A is required for normal VLDL assembly remains unknown.

Author(s): 
Cano, Ainara
Buqué, Xabier
Martínez-Uña, Maite
Aurrekoetxea, Igor
Menor, Ariane
García-Rodríguez, Juan L.
Lu, Shelly C.
Martínez-Chantar, M. Luz
Mato, José M.
Ochoa, Begoña
Aspichueta, Patricia
Publication Title: 
Lipids

Nutritional influences on cardiovascular disease operate throughout life. Studies in both experimental animals and humans have suggested that changes in the peri- and early post-natal nutrition can affect the development of the various components of the metabolic syndrome in adult life. This has lead to the hypothesis that n-3 fatty acid supplementation in pregnancy may have a beneficial effect on lipid profile in the offspring.

Author(s): 
Rytter, Dorte
Schmidt, Erik B.
Bech, Bodil H.
Christensen, Jeppe H.
Henriksen, Tine B.
Olsen, Sjurdur F.

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