Lithium Carbonate

Publication Title: 
L'Encephale

INTRODUCTION: Emotional reactivity and sleep constitute key dimensions of bipolar disorder. Emotional reactivity referred to emotion response intensity and emotion response threshold. Higher emotion reactivity is described during both mood episodes and periods of remission in bipolar disorder. As well, sleep disturbances are described during both acute episodes and euthymic periods in bipolar disorder. Links between sleep and emotion regulation start to be studied in general population.

Author(s): 
Boudebesse, Carole
Henry, Chantal
Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Syrian Golden hamsters prefer and consume large and remarkably constant amounts of ethanol in a simple two-bottle free-choice regimen. Ethanol intake is significantly suppressed by zimelidine, bromocriptine, buspirone, and lithium carbonate, pharmacological agents that have been shown to be beneficial in controlling ethanol intake in alcohol-dependent humans. These results suggest that this ethanol-drinking animal model has high "predictive validity" and can be used effectively in the search for and identification of new agents for the treatment of alcohol abuse.

Author(s): 
Keung, W. M.
Vallee, B. L.
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