Liver Diseases

Publication Title: 
Biological & Pharmaceutical Bulletin

Terminalia chebula has been widely used in India as a folk medicine. This study investigated the in vivo anti-hyperglycemia and anti-diabetic complication effects of the EtOAc-soluble portion of ethanolic extract of T. chebula fruit (EETC) containing 29.4% chebulic acid. Rats were divided into non-diabetic, untreated diabetic and diabetic groups. Streptozotocin (40 mg/kg body weight (BW))-induced diabetic rats were orally administered the aminoguanidine (100 mg/kg BW), high dose (500 mg/kg BW; HEETC) and low dose (100 mg/kg BW; LEETC) for 13 weeks.

Author(s): 
Kim, Ji-hoon
Hong, Chung-Oui
Koo, Yun-chang
Kim, Su-Jung
Lee, Kwang-Won
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: The 70% methanol extract of Terminalia chebula Retz. fruit (TCME) was investigated for its in vitro iron chelating property and in vivo ameliorating effect on hepatic injury of iron overloaded mice. METHODS: The effect of fruit extract on Fe2+-ferrozine complex formation and Fe2+ mediated pUC-18 DNA breakdown was studied in order to find the in vitro iron chelating activity. Thirty-six Swiss Albino mice were divided into six groups of: blank, patient control and treated with 50, 100, 200 mg/kg b.w.

Author(s): 
Sarkar, Rhitajit
Hazra, Bibhabasu
Mandal, Nripendranath
Publication Title: 
Archives of Gerontology and Geriatrics

Thiazolidine-4-carboxylic acid (TC) is a cyclic sulfur amino acid, a condensation product of cysteine and formaldehyde. The chemistry, biological effects and clinical use of TC are reviewed. Extensive animal experiments and studies on human subjects carried out in Europe indicate that a combination of TC and folic acid, 'Folcysteine', has revitalizing effects on age-related biochemical variables of blood and tissues. Further animal studies confirmed the anti-toxic effects of TC, particularly on the liver.

Author(s): 
Weber, H. U.
Fleming, J. F.
Miquel, J.
Publication Title: 
Thrombosis and Haemostasis

Evidence has been sought of activation of the coagulation system in two groups of patients following the infusion of two heparinised clotting factor concentrates. No changes were detected in 13 patients with mild hepatic dysfunction. In six studies on patients with Christmas disease induced abnormalities occurred in only one. Activation of the coagulation mechanism did not occur in another individual who had received the same batch of material.

Author(s): 
Preston, F. E.
Malia, R. G.
Lilleyman, J. S.
Blackburn, E. K.
Publication Title: 
Stem Cell Reports

Induced pluripotent stem cells (iPSCs) provide an inexhaustible source of cells for modeling disease and testing drugs. Here we develop a bioinformatic approach to detect differences between the genomic programs of iPSCs derived from diseased versus normal human cohorts as they emerge during in†vitro directed differentiation. Using iPSCs generated from a cohort carrying mutations (PiZZ) in the gene responsible for alpha-1 antitrypsin (AAT) deficiency, we find that the global transcriptomes of PiZZ iPSCs diverge from normal controls upon differentiation to hepatic cells.

Author(s): 
Wilson, Andrew A.
Ying, Lei
Liesa, Marc
Segeritz, Charis-Patricia
Mills, Jason A.
Shen, Steven S.
Jean, Jyhchang
Lonza, Geordie C.
Liberti, Derek C.
Lang, Alex H.
Nazaire, Jean
Gower, Adam C.
M¸eller, Franz-Josef
Mehta, Pankaj
OrdÛÒez, Adriana
Lomas, David A.
Vallier, Ludovic
Murphy, George J.
Mostoslavsky, Gustavo
Spira, Avrum
Shirihai, Orian S.
Ramirez, Maria I.
Gadue, Paul
Kotton, Darrell N.
Publication Title: 
American Journal of Transplantation: Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons

There are no published series of the assessment process, profiles and outcomes of anonymous, directed or nondirected live liver donation. The outcomes of 29 consecutive potential anonymous liver donors at our center were assessed. We used our standard live liver assessment process, augmented with the following additional acceptance criteria: a logical rationale for donation, a history of social altruism, strong social supports and a willingness to maintain confidentiality of patient information.

Author(s): 
Reichman, T. W.
Fox, A.
Adcock, L.
Wright, L.
Abbey, S. E.
Levy, G.
Grant, D. R.
Publication Title: 
Compendium of Continuing Education in Dentistry (Jamesburg, N.J.: 1995)

Sedating medically compromised patients (i.e., geriatric patients, patients with cardiac, kidney, or liver diseases, and those with other severe systemic conditions) for dental procedures can increase the risk of adverse events for this group of patients and can also increase the risk of liability for the clinician. The authors treated 17 apprehensive dental patients with a combination technique using hypnosis and sedative drugs. The use of hypnosis reduced the amount of sedative agent required and alleviated patient anxiety.

Author(s): 
Lu, D. P.
Lu, G. P.
Publication Title: 
Yonsei Medical Journal

PURPOSE: The purpose of this study was to investigate the influence of chronic virus- related liver disease severity on propofol requirements. MATERIALS AND METHODS: In this study, 48 male patients with chronic hepatitis B infection were divided into three groups according to Child-Turcotte-Pugh classification of liver function (groups A, B, and C with mild, moderate and severe liver disease, respectively). After intubation, propofol concentration was adjusted by ± 0.3 ?g/mL increments to maintain bispectral index in the range of 40-60.

Author(s): 
Wu, Jian
Huang, Su-Qin
Chen, Qing-Lian
Zheng, Shu-Sen
Publication Title: 
Acta Pharmacologica Sinica

Hepatitis B virus (HBV) or hepatitis C virus (HCV) infections are a major threat worldwide. Combination therapy of interferon-alpha and ribavirin is currently the treatment of choice for HCV-infected patients. However, this regimen is only effective in approximately 50% of patients and provokes severe side-effects. Numerous natural alternatives for treating HCV have been suggested. Deoxynojirimycin and its derivatives are iminosugars which exert anti-HCV activity by inhibiting alpha-glucosidases.

Author(s): 
Wohlfarth, Carolin
Efferth, Thomas
Publication Title: 
PloS One

Acute stress affects cellular integrity in many tissues including the liver, but its underlying mechanism is still unclear. The aim of the present study was to investigate the potential involvement of catecholamines and adrenoceptors in the regulation of acute restraint stress-induced liver injury. Restraint was achieved by placing mice in restraint tubes.

Author(s): 
Zhu, Qing
Gu, Liwei
Wang, Yimei
Jia, Li
Zhao, Zengming
Peng, Shuangqing
Lei, Linsheng

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