Liver Neoplasms

Publication Title: 
The Biochemical Journal

NaCT (sodium-coupled citrate transporter) is an Na(+)-coupled citrate transporter identified recently in mammals that mediates the cellular uptake of citrate. It is expressed predominantly in the liver. NaCT is structurally and functionally related to the product of the Indy (I'm not dead yet) gene in Drosophila, the dysfunction of which leads to lifespan extension. Here, we show that NaCT mediates the utilization of extracellular citrate for fat synthesis in human liver cells, and that the process is stimulated by lithium.

Author(s): 
Inoue, Katsuhisa
Zhuang, Lina
Maddox, Dennis M.
Smith, Sylvia B.
Ganapathy, Vadivel
Publication Title: 
Oncology Reports

SIRT1 is the human orthologue of SIR2, a conserved NAD-dependent protein deacetylase that regulates longevity in yeast and in Caenorhabditis elegans. Overexpression of SIRT1 in cancer tissue, compared with normal tissue, has been demonstrated, suggesting that SIRT1 may act as a tumor promoter. The function of SIRT1 in liver cancer has not been elucidated. In the present study, SIRT1 re-expression or knockdown was induced in hepatoma cell lines and liver normal cell lines.

Author(s): 
Wang, Hanning
Liu, Hao
Chen, Kaiyun
Xiao, Jinfeng
He, Ke
Zhang, Jinqian
Xiang, Guoan
Publication Title: 
PloS One

SIRT3, a mitochondrial sirtuin belonging to nicotinamide adenine nucleotide (NAD) dependent deacetylases, is implicated in metabolism, longevity and carcinogenesis. SIRT3 expression and its significance in hepatocellular carcinoma (HCC) remain largely unclear. In this study, we demonstrated that SIRT3 expression in HCC tissue was much lower than that in paracarcinoma tissue, at both mRNA and protein levels. The cutoff value for low SIRT3 expression in HCC was defined according to receiver operating characteristic curve (ROC) analysis.

Author(s): 
Zhang, Chris Zhiyi
Liu, Lili
Cai, Muyan
Pan, Yinghua
Fu, Jia
Cao, Yun
Yun, Jingping
Publication Title: 
Molecular Cancer Therapeutics

Sirtuins (SIRT1-7) are a highly conserved family of NAD(+)-dependent enzymes that control the activity of histone and nonhistone regulatory proteins. SIRT1 is purposed to promote longevity and to suppress the initiation of some cancers. Nevertheless, SIRT1 is reported to function as a tumor suppressor as well as an oncogenic protein. Our data show that compared with normal liver or surrounding tumor tissue, SIRT1 is strongly overexpressed in human hepatocellular carcinoma (HCC).

Author(s): 
Portmann, Simone
Fahrner, RenÈ
Lechleiter, Antje
Keogh, Adrian
Overney, Sarah
Laemmle, Alexander
Mikami, Kei
Montani, Matteo
Tschan, Mario P.
Candinas, Daniel
Stroka, Deborah
Publication Title: 
International Journal of Cancer. Journal International Du Cancer

Haiti exemplifies all of the problems of developing countries: poverty, hunger, reduced longevity, and an illiteracy rate of more than 75%. It is, therefore, not surprising that so little attention has been given to late-onset chronic diseases, particularly cancer. The results of a special survey of cancer cases first diagnosed in 1979-84 are presented, with relative proportions of cancers by site, according to age, sex and geographical area of origin (coastal vs. mountain).

Author(s): 
Mitacek, E. J.
St Vallieres, D.
Polednak, A. P.
Publication Title: 
Postgraduate Medicine

Colorectal cancer is more common in the Western world than in underdeveloped countries. Diet, longevity, heredity, and presence of other bowel diseases may affect the incidence. Diagnosis is based on results of routine laboratory studies and evaluation of the entire large bowel with air-contrast barium enema and colonoscopy. Surgical resection is the primary therapy for colorectal cancer. Postoperative systemic chemotherapy yields poor results, but hepatic artery infusional chemotherapy offers some benefit to patients who have only hepatic metastases.

Author(s): 
Bruckstein, A. H.
Publication Title: 
Transplantation

In cadaveric liver transplantation, the Milan criteria have been accepted as the selection criteria for hepatocellular carcinoma (HCC) patients in considering organ allocation. However, the situation is different in living-donor liver transplantation (LDLT), in which the donor has a strong preference for altruism. The authors describe herein their experience with LDLT for HCC patients using their patient selection criteria. From February 1999 to March 2002, right lobe LDLT was performed in 56 patients with HCC.

Author(s): 
Kaihara, Satoshi
Kiuchi, Tetsuya
Ueda, Mikiko
Oike, Fumitaka
Fujimoto, Yasuhiro
Ogawa, Kohei
Kozaki, Koichi
Tanaka, Koichi
Publication Title: 
European Journal of Cancer Care

Recruitment of patients into drug trials is essential in order to evaluate new treatments. Knowing why patients enter drug trials and their fears regarding them can be used in future research to ensure good recruitment and provide a supportive atmosphere for patients. Forty patients with colorectal cancer and 30 patients with colorectal liver metastases were asked to participate in a drug trial involving the oral consumption of a diet-derived agent of unknown therapeutic action.

Author(s): 
Garcea, G.
Lloyd, T.
Steward, W. P.
Dennison, A. R.
Berry, D. P.
Publication Title: 
AJR. American journal of roentgenology

OBJECTIVE: This study sought to evaluate whether surgical clips affect tissue conductivity and thereby alter the induction of radiofrequency ablation lesions and to determine whether therapy is safe after previous placement of clips in the liver. MATERIALS AND METHODS: An ex vivo porcine hepatic model was used. Three clips were placed around a radiofrequency electrode at 10, 20, and 30 mm from the point of insertion. Clips were arranged in a plane either perpendicular or parallel to the electrode track.

Author(s): 
Boll, Daniel T.
Lewin, Jonathan S.
Duerk, Jeffrey L.
Merkle, Elmar M.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

The cytotoxicities of 2 derivatives of artemisinin B and 2 derivatives of artemisic acid (designated as Compound A, B, C, and D) were investigated, using trypan blue dye exclusion test and colony-forming units assay. At the concentration of 5 micrograms.ml-1, the inhibition rates of these 4 compounds against murine leukemia cell line P388 were > 85%.

Author(s): 
Sun, W. C.
Han, J. X.
Yang, W. Y.
Deng, D. A.
Yue, X. F.

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