Lod Score

Publication Title: 
Proceedings of the National Academy of Sciences of the United States of America

Substantial evidence supports the familial aggregation of exceptional longevity. The existence of rare families demonstrating clustering for this phenotype suggests that a genetic etiology may be an important component. Previous attempts at localizing loci predisposing for exceptional longevity have been limited to association studies of candidate gene polymorphisms. In this study, a genome-wide scan for such predisposing loci was conducted by using 308 individuals belonging to 137 sibships demonstrating exceptional longevity.

Puca, A. A.
Daly, M. J.
Brewster, S. J.
Matise, T. C.
Barrett, J.
Shea-Drinkwater, M.
Kang, S.
Joyce, E.
Nicoli, J.
Benson, E.
Kunkel, L. M.
Perls, T.
Publication Title: 
PloS One

BACKGROUND: Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the general population. METHODOLOGY/PRINCIPAL FINDINGS: To map the loci conferring a survival advantage, we performed the second genomewide linkage scan on human longevity and the first using a high-density marker panel of single nucleotide polymorphisms.

Boyden, Steven E.
Kunkel, Louis M.
Publication Title: 

Leukocyte telomere length is widely considered a biomarker of human age and in many studies indicative of health or disease. We have obtained quantitative estimates of telomere length from blood leukocytes in a population sample, confirming results of previous studies that telomere length significantly decreases with age. Telomere length was also positively associated with several measures of healthy aging, but this relationship was dependent on age.

Kim, Sangkyu
Bi, Xiuhua
Czarny-Ratajczak, Malwina
Dai, Jianliang
Welsh, David A.
Myers, Leann
Welsch, Michael A.
Cherry, Katie E.
Arnold, Jonathan
Poon, Leonard W.
Jazwinski, S. Michal
Publication Title: 
Aging Cell

Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118 nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers of 11 European countries as part of the Genetics of Healthy Aging (GEHA) project.

Beekman, Marian
BlanchÈ, HÈlËne
Perola, Markus
Hervonen, Anti
Bezrukov, Vladyslav
Sikora, Ewa
Flachsbart, Friederike
Christiansen, Lene
de Craen, Anton J. M.
Kirkwood, Tom B. L.
Rea, Irene Maeve
Poulain, Michel
Robine, Jean-Marie
Valensin, Silvana
Stazi, Maria Antonietta
Passarino, Giuseppe
Deiana, Luca
Gonos, Efstathios S.
Paternoster, Lavinia
S¯rensen, Thorkild I. A.
Tan, Qihua
Helmer, Quinta
van den Akker, Erik B.
Deelen, Joris
Martella, Francesca
Cordell, Heather J.
Ayers, Kristin L.
Vaupel, James W.
Tˆrnwall, Outi
Johnson, Thomas E.
Schreiber, Stefan
Lathrop, Mark
Skytthe, Axel
Westendorp, Rudi G. J.
Christensen, Kaare
Gampe, Jutta
Nebel, Almut
Houwing-Duistermaat, Jeanine J.
Slagboom, Pieternella Eline
Franceschi, Claudio
GEHA consortium
Publication Title: 
Growth hormone & IGF research: official journal of the Growth Hormone Research Society and the International IGF Research Society

OBJECTIVE: Since a reduction of the insulin/IGF-1 signaling cascade extends life span in many species and IGF-1 signaling might partly mediate the effects of caloric restriction (CR), an experimental intervention for increasing longevity, the purpose of the present study was to use quantitative trait loci (QTL) analysis, an unbiased genetic approach, to identify particular regions of the genome influencing plasma IGF-1 levels in an F2 intercross between F344 and LOU/C rats; the latter being an inbred strain of Wistar origin, considered as a model of healthy aging since it resists to age (an

Marissal-Arvy, Nathalie
Duron, Emmanuelle
Parmentier, Frédéric
Zizzari, Philippe
MormËde, Pierre
Epelbaum, Jacques
Publication Title: 
American Journal of Medical Genetics

The hypothesis that a gene for susceptibility to psychosis (specifically in the X-Y homologous class) is located on the sex chromosomes has been proposed. Such a gene would account for the excess of sex chromosome anomalous males and females in populations of patients with psychosis, a tendency towards concordance by sex within families, and sex differences associated with psychosis and its underlying brain pathology. In earlier studies we observed small positive LOD scores in Xp11, and in a more recent and larger cohort of 178 sibling pairs, a peak multipoint nonparametric LOD score of 1.

DeLisi, L. E.
Shaw, S.
Sherrington, R.
Nanthakumar, B.
Shields, G.
Smith, A. B.
Wellman, N.
Larach, V. W.
Loftus, J.
Razi, K.
Stewart, J.
Comazzi, M.
Vita, A.
de Hert, M.
Crow, T. J.
Publication Title: 
The American Journal of Psychiatry

OBJECTIVE: Some genome-wide scans and association studies for schizophrenia susceptibility genes have yielded significant positive findings, but there is disagreement between studies on their locations, and no mutation has yet been found in any gene. Since schizophrenia is a complex disorder, a study with sufficient power to detect a locus with a small or moderate gene effect is necessary.

DeLisi, Lynn E.
Shaw, Sarah H.
Crow, Timothy J.
Shields, Gail
Smith, Angela B.
Larach, Veronica W.
Wellman, Nigel
Loftus, Josephine
Nanthakumar, Betsy
Razi, Kamran
Stewart, John
Comazzi, Margherita
Vita, Antonio
Heffner, Thomas
Sherrington, Robin
Publication Title: 
Human Genetics

This is the first report of a full genome scan of sexual orientation in men. A sample of 456 individuals from 146 families with two or more gay brothers was genotyped with 403 microsatellite markers at 10-cM intervals. Given that previously reported evidence of maternal loading of transmission of sexual orientation could indicate epigenetic factors acting on autosomal genes, maximum likelihood estimations (mlod) scores were calculated separated for maternal, paternal, and combined transmission.

Mustanski, Brian S.
Dupree, Michael G.
Nievergelt, Caroline M.
Bocklandt, Sven
Schork, Nicholas J.
Hamer, Dean H.
Publication Title: 
The Journal of Veterinary Medical Science / the Japanese Society of Veterinary Science

Females of the inbred mouse RR strain have a limited ability to nurture their offspring, and frequently the young die during rearing. We previously identified a significant quantitative trait locus (QTL) responsible for the inferior nurturing ability on chromosome 5 (Naq1), on the basis of litter weight of six pups at days 7, 12, and 21 after parturition. Here, we carried out further mapping of Naq1 to define the confidence interval precisely.

Suto, Jun-ichi
Sekikawa, Kenji
Publication Title: 
Genetics and molecular research: GMR

Dendrobium officinale is an endangered orchid from southeast Asia that is known for its medicinal properties in traditional Chinese medicine. We constructed an integrated genetic linkage map of an F(1) population derived from an interspecific cross between D. officinale and D. aduncum (both, 2n = 38), using expressed sequence tag-simple sequence repeats (EST-SSR) and sequence-related amplified polymorphism (SRAP). A total of 349 polymorphic loci, including 261 SRAP loci and 88 EST-SSR loci, were identified for genetic linkage analysis.

Lu, J. J.
Wang, S.
Zhao, H. Y.
Liu, J. J.
Wang, H. Z.
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