Logistic Models

Publication Title: 
Mechanisms of Ageing and Development

Understanding mechanisms underlying longevity, and endeavor towards the specific goals of alleviating frailty in old age, require a comprehensive approach that considers the various theoretical and experimental approaches, as well as compiling the data on humans. This logistic has underlined the program of the conference, and is reflected in the present special issue. Considerable volume of data now point to distinct genes that are associated with exceptional longevity in humans, as reflected from the articles in this volume.

Author(s): 
Globerson, Amiela
Barzilai, Nir
Publication Title: 
Science (New York, N.Y.)

Human senescence patterns-late onset of mortality increase, slow mortality acceleration, and exceptional longevity-are often described as unique in the animal world.

Author(s): 
Bronikowski, Anne M.
Altmann, Jeanne
Brockman, Diane K.
Cords, Marina
Fedigan, Linda M.
Pusey, Anne
Stoinski, Tara
Morris, William F.
Strier, Karen B.
Alberts, Susan C.
Publication Title: 
Journal of thrombosis and haemostasis: JTH

BACKGROUND: Thromboprophylaxis with rivaroxaban (R) is superior to enoxaparin in patients undergoing major orthopedic surgery (MOS). However, rivaroxaban has never been directly compared with fondaparinux (F), which also shows superior efficacy over enoxaparin. The clinical impact of switching from fondaparinux to rivaroxaban thromboprophylaxis is unclear. OBJECTIVES: To evaluate the efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in unselected patients undergoing MOS.

Author(s): 
Beyer-Westendorf, J.
L¸tzner, J.
Donath, L.
Radke, O. C.
Kuhlisch, E.
Hartmann, A.
Weiss, N.
Werth, S.
Publication Title: 
American Journal of Human Genetics

We previously identified a functional variant of KLOTHO (termed "KL-VS"), which harbors two amino acid substitutions in complete linkage disequilibrium and is associated with reduced human longevity when in homozygosity. Klotho-deficient mice display extensive arteriosclerosis when fed a normal diet, suggesting a potent genetic predisposition.

Author(s): 
Arking, Dan E.
Becker, Diane M.
Yanek, Lisa R.
Fallin, Daniele
Judge, Daniel P.
Moy, Taryn F.
Becker, Lewis C.
Dietz, Harry C.
Publication Title: 
The Journal of Thoracic and Cardiovascular Surgery

OBJECTIVE: With the increasing longevity of heart transplant recipients, the long-term effects of cyclosporine on renal function have become more evident. Highly sensitive, early, and effective monitoring of posttransplant renal function is still being researched. This study aimed to evaluate the prognostic value of cystatin C for patients after heart transplantation. METHODS: Seventy-three long-term recipients of a heart transplant more than 5 years before the study start were included in the analysis with a follow-up of 4 years.

Author(s): 
Kniepeiss, Daniela
Wagner, Doris
Wirnsberger, Gerhard
Roller, Regina E.
Wasler, Andr‰
Iberer, Florian
Tscheliessnigg, Karl-Heinz
Publication Title: 
CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne

BACKGROUND: Increases in life expectancy make it important to remain healthy for as long as possible. Our objective was to examine the extent to which healthy behaviours in midlife, separately and in combination, predict successful aging. METHODS: We used a prospective cohort design involving 5100 men and women aged 42-63 years. Participants were free of cancer, coronary artery disease and stroke when their health behaviours were assessed in 1991-1994 as part of the Whitehall II study. We defined healthy behaviours as never smoking, moderate alcohol consumption, physical activity (?

Author(s): 
Sabia, SÈverine
Singh-Manoux, Archana
Hagger-Johnson, Gareth
Cambois, Emmanuelle
Brunner, Eric J.
Kivimaki, Mika
Publication Title: 
Journal of Renal Nutrition: The Official Journal of the Council on Renal Nutrition of the National Kidney Foundation

OBJECTIVES: The aim of this work was to evaluate the correlation between the amount of weekly fish intake and kidney function as measured by creatinine clearance (CCr) rate among elderly inhabitants of Ikaria Island, a place that has been related to an increased rate of longevity. METHODS: From June to October of 2009, 673 males and females, aged 65-100 years and long-term residents of Ikaria Island were enrolled. Of those, 328 (75†±†7 years) were males and 339 (75†±†6 years) were females.

Author(s): 
Chrysohoou, Christina
Pitsavos, Christos
Panagiotakos, Demosthenes
Skoumas, John
Lazaros, George
Oikonomou, Evangelos
Galiatsatos, Nikos
Striggou, Marina
Xynogala, Maria
Stefanadis, Christodoulos
Publication Title: 
International psychogeriatrics / IPA

BACKGROUND: Previous research has shown that healthy behaviors, such as regular physical exercise, a nutritious diet, and not smoking, are associated with a lower risk for Alzheimer's disease and dementia. However, less is known about the potential link between healthy behaviors and mild memory symptoms that may precede dementia in different age groups.

Author(s): 
Small, Gary W.
Siddarth, Prabha
Ercoli, Linda M.
Chen, Stephen T.
Merrill, David A.
Torres-Gil, Fernando
Publication Title: 
Psychosomatic Medicine

OBJECTIVE: Shortened telomere length has been associated with mortality in patients with coronary heart disease (CHD) and is considered as an emerging marker of biologic age. Whether depression is associated with telomere length or trajectory has not been evaluated in patients with CHD. METHODS: In a prospective cohort study, we measured leukocyte telomere length in 952 participants with stable CHD at baseline and in 608 of these participants after 5 years of follow-up.

Author(s): 
Hoen, Petra W.
de Jonge, Peter
Na, Bee Ya
Farzaneh-Far, Ramin
Epel, Elissa
Lin, Jue
Blackburn, Elizabeth
Whooley, Mary A.
Publication Title: 
Cancer causes & control: CCC

OBJECTIVE: Early menarche is a risk factor for breast cancer. We investigated the variation in age at menarche by socioeconomic status (SES) and race. METHODS: A cohort study was conducted on 1,091 black and 986 white girls from the three sites in the United States as part of the NHLBI Growth and Health Study (NGHS), who were aged 9-10 years at baseline and followed through adolescence over a 10-year period with annual exams.

Author(s): 
Braithwaite, Dejana
Moore, Dan H.
Lustig, Robert H.
Epel, Elissa S.
Ong, Ken K.
Rehkopf, David H.
Wang, May C.
Miller, Suzanne M.
Hiatt, Robert A.

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