Long Interspersed Nucleotide Elements

Publication Title: 
Experimental Cell Research

Soft tissue sarcomas (STS) are characterized by co-participation of several epigenetic and genetic events during tumorigenesis. Having bypassed cellular senescence barriers during oncogenic transformation, the factors further affecting growth rate of STS cells remain poorly understood.

Author(s): 
Becerikli, Mustafa
Jacobsen, Frank
Rittig, Andrea
Kˆhne, Wiebke
Nambiar, Sandeep
Mirmohammadsadegh, Alireza
Stricker, Ingo
Tannapfel, Andrea
Wieczorek, Stefan
Epplen, Joerg Thomas
Tilkorn, Daniel
Steinstraesser, Lars
Publication Title: 
Epigenetics

Klinefelter syndrome (KS) is the most common sex-chromosome aneuploidy in humans. Most affected individuals carry one extra X-chromosome (47,XXY karyotype) and the condition presents with a heterogeneous mix of reproductive, physical and psychiatric phenotypes. Although the mechanism(s) by which the supernumerary X-chromosome determines these features of KS are poorly understood, skewed X-chromosome inactivation (XCI), gene-dosage dysregulation, and the parental origin of the extra X-chromosome have all been implicated, suggesting an important role for epigenetic processes.

Author(s): 
Viana, Joana
Pidsley, Ruth
Troakes, Claire
Spiers, Helen
Wong, Chloe Cy
Al-Sarraj, Safa
Craig, Ian
Schalkwyk, Leonard
Mill, Jonathan
Publication Title: 
Epigenomics

AIM: We investigated methylation of DNA repetitive sequences (LINE-1 and BAGE) in peripheral blood leukocytes from first-episode schizophrenia (FES) patients and healthy controls (HCs) with respect to childhood adversities. MATERIALS & METHODS: Patients were divided into two subgroups based on the history of childhood trauma - FES(+) and FES(-) subjects. The majority of HCs had a negative history of childhood trauma - HCs(-) subjects. RESULTS: FES(+) patients had significantly lower LINE-1 methylation in comparison with FES(-) patients or HC(-) subjects.

Author(s): 
Misiak, B?a?ej
Szmida, El?bieta
Karpi?ski, Pawe?
Loska, Olga
S?siadek, Maria M.
Frydecka, Dorota
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