Lymphocyte Activation

Publication Title: 
Age (Dordrecht, Netherlands)

The B cell arm of adaptive immunity undergoes significant modifications with age. Elderly people are characterized by impaired B cell responses reflected in a reduced ability to effectively respond against viruses and bacteria. Alterations of immunity with advancing age (immunosenescence) have been widely studied in centenarians who are considered a good example of successful aging. In recent years, attention has shifted to centenarian offspring (CO) as a model of people genetically advantaged for healthy aging and longevity.

Author(s): 
Buffa, Silvio
PellicanÚ, Mariavaleria
Bulati, Matteo
Martorana, Adriana
Goldeck, David
Caruso, Calogero
Pawelec, Graham
Colonna-Romano, Giuseppina
Publication Title: 
Journal of Immunology (Baltimore, Md.: 1950)

It is well accepted that Ag-induced B cell differentiation often results in the generation of exceptionally long-lived plasma cells. Much of the work supporting this viewpoint stems from studies focused on germinal center-derived plasma cells secreting high-affinity isotype-switched Abs in mice immunized with T cell-dependent Ags. In contrast, less attention has been devoted to understanding Ab responses to T cell-independent Ags and pathogens.

Author(s): 
Bortnick, Alexandra
Allman, David
Publication Title: 
Clinical and Experimental Immunology

Immunodeficient mice bearing targeted mutations in the IL2rg gene and engrafted with human immune systems are effective tools for the study of human haematopoiesis, immunity, infectious disease and transplantation biology. The most robust human immune model is generated by implantation of human fetal thymic and liver tissues in irradiated recipients followed by intravenous injection of autologous fetal liver haematopoietic stem cells [often referred to as the BLT (bone marrow, liver, thymus) model].

Author(s): 
Covassin, L.
Jangalwe, S.
Jouvet, N.
Laning, J.
Burzenski, L.
Shultz, L. D.
Brehm, M. A.
Publication Title: 
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

People may reach the upper limits of the human life span at least partly because they have maintained more appropriate immune function, avoiding changes to immunity termed "immunosenescence." Exceptionally long-lived people may be enriched for genes that contribute to their longevity, some of which may bear on immune function. Centenarian offspring would be expected to inherit some of these, which might be reflected in their resistance to immunosenescence, and contribute to their potential longevity.

Author(s): 
PellicanÚ, Mariavaleria
Buffa, Silvio
Goldeck, David
Bulati, Matteo
Martorana, Adriana
Caruso, Calogero
Colonna-Romano, Giuseppina
Pawelec, Graham
Publication Title: 
Terapevticheski? Arkhiv
Author(s): 
Mazharov, M. K.
Publication Title: 
PloS One

OBJECTIVE: The level of T cell activation in untreated HIV disease is strongly and independently associated with risk of immunologic and clinical progression. The factors that influence the level of activation, however, are not fully defined. Since endogenous glucocorticoids are important in regulating inflammation, we sought to determine whether less optimal diurnal cortisol patterns are associated with greater T cell activation. METHODS: We studied 128 HIV-infected adults who were not on treatment and had a CD4(+) T cell count above 250 cells/µl.

Author(s): 
Patterson, Sarah
Moran, Patricia
Epel, Elissa
Sinclair, Elizabeth
Kemeny, Margaret E.
Deeks, Steven G.
Bacchetti, Peter
Acree, Michael
Epling, Lorrie
Kirschbaum, Clemens
Hecht, Frederick M.
Publication Title: 
Translational Psychiatry

Bipolar disorder (BD) is a severe mental disorder characterized by recurrent episodes of mania and depression. Serotonin transporter (HTT) is a target of antidepressants and is one of the strongest candidate molecules of mood disorder, however, genetic study showed equivocal results. Here, we performed promoter-wide DNA methylation analysis of lymphoblastoid cell lines (LCLs) derived from two pairs of monozygotic twins discordant for BD.

Author(s): 
Sugawara, H.
Iwamoto, K.
Bundo, M.
Ueda, J.
Miyauchi, T.
Komori, A.
Kazuno, A.
Adati, N.
Kusumi, I.
Okazaki, Y.
Ishigooka, J.
Kojima, T.
Kato, T.
Publication Title: 
Journal of Consulting and Clinical Psychology

To assess the influence of a hypnotic intervention on cellular immune function during a commonplace stressful event, the authors selected 33 medical and dental students on the basis of hypnotic susceptibility. Initial blood samples were obtained during a lower stress period, and a second sample was drawn 3 days before the first major exam of the term. Half of the participants were randomly assigned to hypnotic-relaxation training in the interval between samples.

Author(s): 
Kiecolt-Glaser, J. K.
Marucha, P. T.
Atkinson, C.
Glaser, R.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

Immunoregulatory properties of a novel antimalarial drug dihydroartemisinin (DHA) were investigated in vitro. DHA 0.5-5 mumol.L-1 enhanced the lymphocyte proliferation induced by Con A. Interleukin 2 (IL-2) production and its mRNA expression by both Con A-stimulated mouse splenocytes and a T cell line LBRM-33-1A5 were also augmented by DHA. In contrast, DHA 0.5-5 mumol.L-1 did not show any effect on the lipopolysaccharides (LPS)-induced lymphocyte proliferation and the spontaneous and mitogen-induced proliferation of transformed T cells.

Author(s): 
Yang, S. X.
Xie, S. S.
Ma, D. L.
Gao, H. L.
Long, Z. Z.
Publication Title: 
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica

AIM: To study the effects of artesunate (dihydroartemisinine-12-alpha-succinate, Art) on immune function in mice. METHODS: Hemolysin concentration was determined by colorimetric method. Serum IgG and C3 contents were measured by single immunodiffusion method. Percentage of lymphocyte transformation, phagocytosis percentage and phagocytic index were counted under microscope. RESULTS: Art im 75 mg kg-1 bid x 7 d decreased the humolysin-forming capacity and levels of serum IgG of mice sensitized with sheep red blood cell.

Author(s): 
Lin, P. Y.
Feng, Z. M.
Pan, J. Q.
Zhang, D.
Xiao, L. Y.

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