Lymphocyte Subsets

Publication Title: 
Nature Communications

Insulin-like growth factor 1 (IGF-1) is a critical regulator of many physiological functions, ranging from longevity to immunity. However, little is known about the role of IGF-1 in natural killer cell development and function. Here, we identify an essential role for IGF-1 in the positive regulation of human natural killer cell development and cytotoxicity. Specifically, we show that human natural killer cells have the ability to produce IGF-1 and that differential endogenous IGF-1 expression leads to disparate cytotoxicity in human primary natural killer cells.

Author(s): 
Ni, Fang
Sun, Rui
Fu, Binqing
Wang, Fuyan
Guo, Chuang
Tian, Zhigang
Wei, Haiming
Publication Title: 
Journal of Immunological Methods

Telomeres are the DNA-protein complexes that protect the ends of eukaryotic chromosomes. The cellular enzyme telomerase counteracts telomere shortening by adding telomeric DNA. A growing body of literature links shorter telomere length and lower telomerase activity with various age-related diseases and earlier mortality. Thus, leukocyte telomere length (LTL) and telomerase activity are emerging both as biomarkers and contributing factors for age-related diseases.

Author(s): 
Lin, Jue
Epel, Elissa
Cheon, Joshua
Kroenke, Candyce
Sinclair, Elizabeth
Bigos, Marty
Wolkowitz, Owen
Mellon, Synthia
Blackburn, Elizabeth
Publication Title: 
Journal of Immunological Methods

Telomeres are the DNA-protein complexes that protect the ends of eukaryotic chromosomes. The cellular enzyme telomerase counteracts telomere shortening by adding telomeric DNA. A growing body of literature links shorter telomere length and lower telomerase activity with various age-related diseases and earlier mortality. Thus, leukocyte telomere length (LTL) and telomerase activity are emerging both as biomarkers and contributing factors for age-related diseases.

Author(s): 
Lin, Jue
Epel, Elissa
Cheon, Joshua
Kroenke, Candyce
Sinclair, Elizabeth
Bigos, Marty
Wolkowitz, Owen
Mellon, Synthia
Blackburn, Elizabeth
Publication Title: 
Neuromolecular Medicine

DNA methylation, which is the transference of a methyl group to the 5'-carbon position of the cytosine in a CpG dinucleotide, is one of the major mechanisms of epigenetic modifications. A number of studies have demonstrated altered DNA methylation of peripheral blood cells in schizophrenia (SCZ) in previous studies.

Author(s): 
Kinoshita, Makoto
Numata, Shusuke
Tajima, Atsushi
Ohi, Kazutaka
Hashimoto, Ryota
Shimodera, Shinji
Imoto, Issei
Takeda, Masatoshi
Ohmori, Tetsuro
Publication Title: 
Brain Research Bulletin

In a prospective randomised controlled trial, 48 students were randomly assigned to stress reduction training before exams with self-hypnosis, Johrei or a mock neurofeedback relaxation control. Peripheral blood lymphocyte subpopulations and self-reported stress (Perceived Stress Scale) were measured before training and 1-2 months later as exams approached. Absolute number and percentages of CD3(+)CD4(+) and CD3(+)CD8(+) T lymphocytes, CD3(-)CD56(+) Natural Killer cells (NK cells) and NK cell cytotoxic activity was measured from venous blood.

Author(s): 
Naito, Akira
Laidlaw, Tannis M.
Henderson, Don C.
Farahani, Linda
Dwivedi, Prabudha
Gruzelier, John H.
Publication Title: 
Phytotherapy research: PTR

Indukantha Ghritha (IG), a polyherbal drug used for centuries in Ayurveda, is claimed to be successful in the treatment of respiratory diseases and as a rejuvenating drug. To date, little is known about the immunomodulatory role of IG in recurrent upper respiratory tract infections (RURIs). This study was designed to scientifically validate and evaluate the immunological response mechanisms in patients with RURI.

Author(s): 
Radhakrishnan, Rajesh
George, Suraj K.
Kumar, Sunil
Balaram, Prabha
Publication Title: 
Cellular Immunology

Accumulating evidences support that CD4(+)CD25(high) T regulatory (Treg) cells play an essential role in controlling and preventing autoimmunity. Paradoxically, RA patients have elevated numbers of circulating CD4(+)CD25(high) T cells, however, the inflammation is still ongoing. Further identification of these CD4(+)CD25(high) T cells may contribute to a better understanding of underlying mechanisms. We show here that these CD4(+)CD25(high) T cells were composed of CD4(+)CD25(high)FoxP3(+) Treg cells and activated CD4(+)CD25(high)FoxP3(-) effector cells.

Author(s): 
Han, Guang Ming
O'Neil-Andersen, Nancy J.
Zurier, Robert B.
Lawrence, David A.
Publication Title: 
Veterinary Immunology and Immunopathology

γδ T cell responses are induced by various viral and bacterial infections. Different γδ T cells contribute to activation and regulation of the inflammatory response and to epithelial repair. How γδ T cells respond to rotavirus infection and how the colonization of probiotics influences the γδ T cell response were unknown.

Author(s): 
Wen, Ke
Li, Guohua
Zhang, Wei
Azevedo, Marli S. P.
Saif, Linda J.
Liu, Fangning
Bui, Tammy
Yousef, Ahmed
Yuan, Lijuan
Publication Title: 
PloS One

γδ T cells have been postulated to act as a first line of defense against infectious agents, particularly intracellular pathogens, representing an important link between the innate and adaptive immune responses. Human γδ T cells expand in the blood of brucellosis patients and are active against Brucella in vitro. However, the role of γδ T cells in vivo during experimental brucellosis has not been studied. Here we report TCRδ(-/-) mice are more susceptible to B. abortus infection than C57BL/6 mice at one week post-infection as measured by splenic colonization and splenomegaly.

Author(s): 
Skyberg, Jerod A.
Thornburg, Theresa
Rollins, Maryclare
Huarte, Eduardo
Jutila, Mark A.
Pascual, David W.
Publication Title: 
Pediatrics

OBJECTIVES: The aim of this study was to investigate the effects of massage therapy (MT) on the immune system of preterm infants. The primary hypothesis was that MT compared with sham therapy (control) will enhance the immune system of stable premature infants by increasing the proportion of their natural killer (NK) cell numbers. METHODS: A randomized placebo-controlled trial of MT versus sham therapy (control) was conducted among stable premature infants in the NICU. Study intervention was provided 5 days per week until hospital discharge for a maximum of 4 weeks.

Author(s): 
Ang, Jocelyn Y.
Lua, Jorge L.
Mathur, Ambika
Thomas, Ronald
Asmar, Basim I.
Savasan, Sureyya
Buck, Steven
Long, Michael
Shankaran, Seetha

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