Lysophospholipids

Publication Title: 
European Cells & Materials

Covalent modifications of titanium with small molecules known to promote human osteoblast maturation are especially attractive in developing superior biomaterials. An important step in securing competent bone formation at implant sites is promoting the formation of mature osteoblasts, either from committed pre-osteoblasts or from their mesenchymal progenitors.

Author(s): 
Mansell, Jason P.
Brown, Judith
Knapp, Jonathan G.
Faul, Charl F. J.
Blom, Ashley W.
Publication Title: 
Molecular Medicine (Cambridge, Mass.)

Cerebral malaria (CM) is associated with excessive inflammatory responses and endothelial activation. Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, inflammation and T-cell migration. We hypothesized that altered S1P signaling during malaria contributes to endothelial activation and inflammation, and show that plasma S1P levels were decreased in Ugandan children with CM compared with children with uncomplicated malaria.

Author(s): 
Finney, Constance Am
Hawkes, Cheryl A.
Kain, Dylan C.
Dhabangi, Aggrey
Musoke, Charles
Cserti-Gazdewich, Christine
Oravecz, Tamas
Liles, W. Conrad
Kain, Kevin C.
Publication Title: 
Glycobiology

Ophiopogon japonicus is a traditional Chinese medicine used to treat cardiovascular disease. Recent studies have confirmed its beneficial properties, but not the mechanism of action. Herein, we investigate the anti-ischemic properties of a water-soluble beta-d-fructan (MDG-1) from Ophiopogon japonicus, and assess the cytoprotective and proangiogenic effects of MDG-1.

Author(s): 
Wang, Shuo
Zhang, Zhang
Lin, Xiao
Xu, De-Sheng
Feng, Yi
Ding, Kan
Publication Title: 
Acta Pharmacologica Sinica

Ginseng, the root of Panax ginseng, has been used in traditional Chinese medicine as a tonic herb that provides many beneficial effects. Pharmacologic studies in the last decades have shown that ginsenosides (ginseng saponins) are primarily responsible for the actions of ginseng. However, the effects of ginseng are not fully explained by ginsenosides. Recently, another class of active ingredients called gintonin was identified. Gintonin is a complex of glycosylated ginseng proteins containing lysophosphatidic acids (LPAs) that are the intracellular lipid mitogenic mediator.

Author(s): 
Im, Dong-soon
Nah, Seung-yeol
Subscribe to RSS - Lysophospholipids