Macrophages, Peritoneal

Publication Title: 
International Immunopharmacology

The aim of this study was to investigate the mechanisms of action of Dihydroarteannuin (DHA), a semi-synthesized agent from the starting material artemisinin extracted from the Chinese Traditional Herbs Artemisia annua, on ameliorating the symptoms of lupus on BXSB mice. The concentration of TNF-alpha in the culture supernatant of the peritoneal macrophages and in the sera of BXSB mice was determined by the ELISA method. NF-kappaB protein expression and translocation were assayed by the EMSA method and laser confocal scanning microscopy method, respectively.

Author(s): 
Li, Wei-dong
Dong, Yan-jun
Tu, You-you
Lin, Zhi-bin
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Maharishi Amrit Kalash (MAK) 5, one of the Ayurvedic food supplements, belongs to a group of substances known as Rasayana. MAK5 and other Rasayanas are believed to enhance the body's resistance to infections and disease, and enhance longevity. In this study, we determined the effects of administration of MAK5, one of the Ayurvedic food supplements on immune functions in young and old mice.

Author(s): 
Inaba, Ryoichi
Mirbod, Seyed Mohammad
Sugiura, Haruo
Publication Title: 
Journal of Pharmacy & Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques

PURPOSE: Down-regulation of lipopolysaccharide (LPS) induced hyper-inflammatory response by non-toxic pharmacological agents acquires paramount importance for countering bacterial sepsis. Anti-inflammatory potential of aqueous extract of Podophyllum hexandrum, a plant well documented in Ayurvedic literature for various therapeutic purposes, was investigated. METHODS: In vivo studies were performed on Balb/c mice pre-treated with supra-lethal dose of LPS endotoxin (E.coli 055:B5) with or without treatment with P. hexandrum extract (RP-1).

Author(s): 
Prakash, Hridayesh
Ali, Arif
Bala, Madhu
Goel, Harish Chandra
Publication Title: 
Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene

To evaluate the immunomodulatory effects of two kinds of Ayurvedic food supplements (Maharishi Amrit Kalash 4 and Maharishi Amrit Kalash 5, M-4 and M-5), superoxide anion (O2-) production of peritoneal macrophages and the response of spleen cells to concanavalin A (Con A) were examined in mice given an aqueous emulsion of M-4 and M-5 p.o. at doses of 50 and 100 mg/kg for 10 days. O2- production of peritoneal macrophages in the M-5 (50 mg/kg)-treated group was significantly higher than that in the control group.

Author(s): 
Inaba, R.
Sugiura, H.
Iwata, H.
Publication Title: 
Phytotherapy research: PTR

Piper longum fruit, used in traditional remedies as well as in the Ayurvedic system of medicine against intestinal disorders, was tested for its efficacy against experimental infection of Giardia lamblia in mice. On in vitro test, an aqueous extract of P. longum fruit powder (PF) at 250 microg/mL and its ethanol extract at 125 microg/mL showed 100% giardicidal activity. A low order activity was found in the n-butanol extract. Further fractionation in hexane and chloroform resulted in a total loss of activity. The survival of-trophozoites in mice at 900 mg/kg body weight was 11.12 in PF, 8.

Author(s): 
Tripathi, D. M.
Gupta, N.
Lakshmi, V.
Saxena, K. C.
Agrawal, A. K.
Publication Title: 
The Indian Journal of Medical Research

BACKGROUND & OBJECTIVES: Gold preparations are highly valued in Indian systems of medicine and extensively used for tonic and rejuvenating properties. This study was aimed to evaluate the effects of Ayurvedic gold preparation Swarna Bhasma (SB) and Unani preparation Kushta Tila Kalan (KTK) on non-specific immunity in mice. A gold-containing drug auranofin (AN) used in modern medicine was studied for comparison. METHODS: Male mice were administered with the incremental doses of these drugs orally for 10 days.

Author(s): 
Bajaj, S.
Ahmad, I.
Raisuddin, S.
Vohora, S. B.
Publication Title: 
BMC complementary and alternative medicine

BACKGROUND: Maharishi Amrit Kalash (MAK) 5, one of the Ayurvedic food supplements, belongs to a group of substances known as Rasayana. MAK5 and other Rasayanas are believed to enhance the body's resistance to infections and disease, and enhance longevity. In this study, we determined the effects of administration of MAK5, one of the Ayurvedic food supplements on immune functions in young and old mice.

Author(s): 
Inaba, Ryoichi
Mirbod, Seyed Mohammad
Sugiura, Haruo
Publication Title: 
Journal of Pharmacy & Pharmaceutical Sciences: A Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques

PURPOSE: Down-regulation of lipopolysaccharide (LPS) induced hyper-inflammatory response by non-toxic pharmacological agents acquires paramount importance for countering bacterial sepsis. Anti-inflammatory potential of aqueous extract of Podophyllum hexandrum, a plant well documented in Ayurvedic literature for various therapeutic purposes, was investigated. METHODS: In vivo studies were performed on Balb/c mice pre-treated with supra-lethal dose of LPS endotoxin (E.coli 055:B5) with or without treatment with P. hexandrum extract (RP-1).

Author(s): 
Prakash, Hridayesh
Ali, Arif
Bala, Madhu
Goel, Harish Chandra
Publication Title: 
Indian Journal of Experimental Biology

Boswellia serrata, Linn F (Burseraceae) is commonly used in Indian system of medicine (Ayurvedic) as an anti-inflammatory, analgesic, anti-arthritic and anti-proliferative agent. This study was planned to investigate the water-soluble fraction of the oleoresin gum of Boswellia serrata (BS extract) on lipopolysaccharide (LPS) induced nitric oxide (NO) production by macrophages under in vivo and in vitro conditions. In the previous condition, rats were fed on atherogenic diet (2.5% cholesterol, 1% cholic acid, 15.7 % saturated fat) along with the BS extract for 90 days.

Author(s): 
Pandey, Ravi S.
Singh, Birendra K.
Tripathi, Yamini B.
Publication Title: 
Inflammopharmacology

The leaves of Cinnamomum tamala Linn (Lauraceae), component of Indian spices are associated with hypoglycemic property in Ayurveda; however, no report is available towards its immunomodulation property, which has been explored here. The dried powder of CT leaves was extracted with hexane and solvent free extract (CTH) was given orally to rats for 10 days, in various doses. Its effect was studied on peritoneal macrophage functions, and was compared with ascorbic acid (1,000 mg/kg, immune-stimulant) and cyclophosphamide (10 mg/kg, immune-suppressant).

Author(s): 
Chaurasia, J. K.
Pandey, Nidhi
Tripathi, Yamini Bhushan

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