Magnetite Nanoparticles

Publication Title: 
PloS One

Stem cells are increasingly the focus of translational research as well as having emerging roles in human cellular therapy. To support these uses there is a need for improved methods for in vivo cell localization and tracking. In this study, we examined the effects of cell labeling on the in vitro functionality of human adipose-derived mesenchymal stem cells. Our results provide a basis for future in vivo studies investigating implanted cell fate and longevity.

Author(s): 
Blaber, Sinead P.
Hill, Cameron J.
Webster, Rebecca A.
Say, Jana M.
Brown, Louise J.
Wang, Shih-Chang
Vesey, Graham
Herbert, Benjamin Ross
Publication Title: 
International Journal of Nanomedicine

The present study evaluated whether the magnetic nanoparticles of Fe(3)O(4) (MNPs-Fe(3)O(4)) could enhance the activity of artesunate (ART), and to explore its potential mechanisms. Cytotoxicity of the copolymer of ART with MNPs-Fe(3)O(4) on K562 cells was detected by MTT assay and the apoptosis rate of K562 cells was measured by flow cytometry. Protein expression levels of bcl-2, bax, bcl-rambo, caspase-3, and survivin in K562 cells were measured by Western blot.

Author(s): 
Wang, Ying
Han, Yuxiang
Yang, Yingying
Yang, Jingci
Guo, Xiaonan
Zhang, Jingnan
Pan, Ling
Xia, Guohua
Chen, Baoan
Publication Title: 
FASEB journal: official publication of the Federation of American Societies for Experimental Biology

How amphetamine affects the neuroglia in living brains is not well understood. In an effort to elucidate this effect, we investigated neuroglia in response to amphetamine exposure using antisense (AS) or sense (S) phosphorothioate-modified oligodeoxynucleotide (sODN) sequences that correspond to glial fibrillary acidic protein (GFAP) mRNA (AS-gfap or S-gfap, respectively) expression. The control is a random-sequence sODN (Ran).

Author(s): 
Liu, Christina H.
Yang, Jinsheng
Ren, Jia Q.
Liu, Charng-Ming
You, Zerong
Liu, Philip K.
Publication Title: 
Journal of Chromatography. A

Dioscorea nipponica and the preparations made from it have been used for long to prevent and treat coronary heart disease in traditional Chinese medicine. A group of steroidal saponins present in the plant are believed to be the active ingredients. It has been a challenge to study the individual saponins separately due to the similarities in their chemical and physical properties. In this work, human serum albumin (HSA) functionalized magnetic nanoparticles (MNPs) were used to isolate and identify saponin ligands that bind to HSA from D. nipponica extract.

Author(s): 
Qinga, Lin-Sen
Xue, Ying
Zheng, Yi
Xiong, Jing
Liao, Xun
Ding, Li-Sheng
Li, Bo-Gang
Liu, Yi-Ming
Publication Title: 
International Journal of Nanomedicine

Traditional Chinese medicine is gradually becoming a new source of anticancer drugs. One such example is wogonin, which is cytotoxic to various cancer cell lines in vitro. However, due to its low water solubility, wogonin is restricted to clinical administration. Recently, the application of drug-coated magnetic nanoparticles (MNPs) to increase water solubility of the drug and to enhance its chemotherapeutic efficiency has attracted much attention.

Author(s): 
Wang, Lei
Zhang, Haijun
Chen, Baoan
Xia, Guohua
Wang, Shuai
Cheng, Jian
Shao, Zeye
Gao, Chong
Bao, Wen
Tian, Liang
Ren, Yanyan
Xu, Peipei
Cai, Xiaohui
Liu, Ran
Wang, Xuemei
Publication Title: 
PloS One

Huperzine A is a bioactive compound derived from traditional Chinese medicine plant Qian Ceng Ta (Huperzia serrata), and was found to have multiple neuroprotective effects. In addition to being a potent acetylcholinesterase inhibitor, it was thought to act through other mechanisms such as antioxidation, antiapoptosis, etc. However, the molecular targets involved with these mechanisms were not identified. In this study, we attempted to exam the interactome of Huperzine A using a cDNA phage display library and also mammalian brain tissue extracts.

Author(s): 
Guo, Wei
Liu, Shupeng
Peng, Jinliang
Wei, Xiaohui
Sun, Ye
Qiu, Yangsheng
Gao, Guangwei
Wang, Peng
Xu, Yuhong
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